Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Alexander A Soukas"'
Autor:
Lucydalila Cedillo, Fasih M Ahsan, Sainan Li, Nicole L Stuhr, Yifei Zhou, Yuyao Zhang, Adebanjo Adedoja, Luke M Murphy, Armen Yerevanian, Sinclair Emans, Khoi Dao, Zhaozhi Li, Nicholas D Peterson, Jeramie Watrous, Mohit Jain, Sudeshna Das, Read Pukkila-Worley, Sean P Curran, Alexander A Soukas
Publikováno v:
eLife, Vol 12 (2023)
Biguanides, including the world’s most prescribed drug for type 2 diabetes, metformin, not only lower blood sugar, but also promote longevity in preclinical models. Epidemiologic studies in humans parallel these findings, indicating favorable effec
Externí odkaz:
https://doaj.org/article/5f9402d37613409b85d1992e1eaa7bee
Autor:
Sarah M Anderson, Hilary K Cheesman, Nicholas D Peterson, J Elizabeth Salisbury, Alexander A Soukas, Read Pukkila-Worley
Publikováno v:
PLoS Pathogens, Vol 15, Iss 6, p e1007893 (2019)
Fatty acids affect a number of physiological processes, in addition to forming the building blocks of membranes and body fat stores. In this study, we uncover a role for the monounsaturated fatty acid oleate in the innate immune response of the nemat
Externí odkaz:
https://doaj.org/article/b7aa2952c0bb4b42877ea9bb534bb241
Autor:
Alexander A Soukas, Ben Zhou
Publikováno v:
PLoS Biology, Vol 17, Iss 5, p e3000285 (2019)
Starvation is among the most ancient of selection pressures, driving evolution of a robust arsenal of starvation survival defenses. In order to survive starvation stress, organisms must be able to curtail anabolic processes during starvation and judi
Externí odkaz:
https://doaj.org/article/c20cc0d000694841ba4627948ed7e448
Publikováno v:
PLoS Genetics, Vol 9, Iss 10, p e1003908 (2013)
Lysosomes are membrane-bound organelles that contain acid hydrolases that degrade cellular proteins, lipids, nucleic acids, and oligosaccharides, and are important for cellular maintenance and protection against age-related decline. Lysosome related
Externí odkaz:
https://doaj.org/article/6bae66992c344f0ab2e27f39fecc684c
Autor:
Sinclair W. Emans, Armen Yerevanian, Fasih M. Ahsan, Yifei Zhou, Lucydalila Cedillo, Alexander A. Soukas
Both Hedgehog (Hh) signaling and target of rapamycin complex 2 (TORC2) are central, evolutionarily conserved pathways that regulate development and metabolism. InC. elegans, loss of essential TORC2 component RICTOR (rict-1) causes delayed development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7aadda13848dce5c8ab82fa5dcf37fe5
https://doi.org/10.1101/2022.11.17.517002
https://doi.org/10.1101/2022.11.17.517002
Autor:
Armen Yerevanian, Luke M. Murphy, Sinclair Emans, Yifei Zhou, Fasih M. Ahsan, Daniel Baker, Sainan Li, Adebanjo Adedoja, Lucydalila Cedillo, Nicole L. Stuhr, Einstein Gnanatheepam, Khoi Dao, Mohit Jain, Sean P. Curran, Irene Georgakoudi, Alexander A. Soukas
Publikováno v:
Aging cell. 21(11)
Riboflavin is an essential cofactor in many enzymatic processes and in the production of flavin adenine dinucleotide (FAD). Here, we report that the partial depletion of riboflavin through knockdown of the C. elegans riboflavin transporter 1 (rft-1)
Autor:
Marie-Louis Wronski, Franziska Plessow, Liya Kerem, Elisa Asanza, Michelle L. O’Donoghue, Fatima C. Stanford, Miriam A. Bredella, Martin Torriani, Alexander A. Soukas, Arvin Kheterpal, Kamryn T. Eddy, Tara M. Holmes, Thilo Deckersbach, Mark Vangel, Laura M. Holsen, Elizabeth A. Lawson
Publikováno v:
Contemporary clinical trials. 122
Obesity affects more than one-third of adults in the U.S., and effective treatment options are urgently needed. Oxytocin administration induces weight loss in animal models of obesity via effects on caloric intake, energy expenditure, and fat metabol
Autor:
Hans M. Dalton, Cole M. Haynes, Chia-An Yen, Sean P. Curran, Sarah M. Anderson, Nandhitha Uma Naresh, James D. Nhan, Dana L Ruter, Hilary K. Cheesman, Christian D. Turner, Read Pukkila-Worley, Alexander A. Soukas
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The transcription factor SKN-1, the Caenorhabditis elegans ortholog of mammalian NRF2, mediates cytoprotective responses to diverse stresses to restore cellular homeostasis. We have discovered that pathogen exposure drives the rapid loss
Autor:
Jeramie D. Watrous, Khoi Dao, Zhaozhi Li, Sudeshna Das, Read Pukkila-Worley, Sinclair Emans, Alexander A. Soukas, Fasih M. Ahsan, Nicholas D. Peterson, Adebanjo Adedoja, Sainan Li, Lucydalila Cedillo, Mohit Jain
Biguanides, including the world’s most commonly prescribed drug for type 2 diabetes, metformin, not only lower blood sugar, but also promote longevity in preclinical models. Epidemiologic studies in humans parallel these findings, indicating favora
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::becd3043c6465d678e82982c5f657b4d
https://doi.org/10.1101/2021.09.02.457410
https://doi.org/10.1101/2021.09.02.457410
Autor:
Armen Yerevanian, Alexander A. Soukas
Publikováno v:
Curr Obes Rep
PURPOSE OF REVIEW: Metformin has multiple benefits for health beyond its antihyperglycemic properties. The purpose of this manuscript is to review the mechanisms that underlie metformin’s effects on obesity. RECENT FINDINGS: Metformin is first line