Zobrazeno 1 - 10
of 437
pro vyhledávání: '"Alexander, Wlodawer"'
Autor:
Alexander Wlodawer, Zbigniew Dauter, Pawel Rubach, Wladek Minor, Joanna I. Loch, Dariusz Brzezinski, Miroslaw Gilski, Mariusz Jaskolski
Publikováno v:
IUCrJ, Vol 11, Iss 6, Pp 966-976 (2024)
The absence of solvent molecules in high-resolution protein crystal structure models deposited in the Protein Data Bank (PDB) contradicts the fact that, for proteins crystallized from aqueous media, water molecules are always expected to bind to the
Externí odkaz:
https://doaj.org/article/34e7ad461dbc4d8db9c0437fa3c8e9c6
Autor:
Zbigniew Dauter, Alexander Wlodawer
Publikováno v:
IUCrJ, Vol 11, Iss 4, Pp 643-644 (2024)
The manuscript `Modeling a unit cell: crystallographic refinement procedure using the biomolecular MD simulation platform Amber' presents a novel protein structure refinement method claimed to offer improvements over traditional techniques like Refma
Externí odkaz:
https://doaj.org/article/52447d7384874996a89fb6252504862c
Autor:
Vandana Mishra, Anuradha Deshmukh, Ishan Rathore, Satadru Chakraborty, Swati Patankar, Alla Gustchina, Alexander Wlodawer, Rickey Y. Yada, Prasenjit Bhaumik
Publikováno v:
Current Research in Structural Biology, Vol 7, Iss , Pp 100128- (2024)
Plasmodium species are causative agents of malaria, a disease that is a serious global health concern. FDA-approved HIV-1 protease inhibitors (HIV-1 PIs) have been reported to be effective in reducing the infection by Plasmodium parasites in the popu
Externí odkaz:
https://doaj.org/article/e7224c26185441e3a44d611f95d5de71
Publikováno v:
Frontiers in Plant Science, Vol 14 (2023)
Halo blight is a plant disease that leads to a significant decrease in the yield of common bean crops and kiwi fruits. The infection is caused by Pseudomonas syringae pathovars that produce phaseolotoxin, an antimetabolite which targets arginine meta
Externí odkaz:
https://doaj.org/article/f2ea9a64544f4e7c9aad38fc04267693
Autor:
Ioannis Tsagakis, Alexander Wlodawer
Publikováno v:
FEBS Open Bio, Vol 12, Iss 9, Pp 1564-1566 (2022)
Alexander Wlodawer has been a member of the FEBS Open Bio Editorial Board since the journal's launch in 2011. Currently, he is Senior Investigator at the Center for Structural Biology, National Cancer Institute in Frederick, Maryland, USA. He receive
Externí odkaz:
https://doaj.org/article/a6cb22fad0df48059c1a9b9d2dbe7507
Autor:
Marek Grabowski, Joanna M. Macnar, Marcin Cymborowski, David R. Cooper, Ivan G. Shabalin, Miroslaw Gilski, Dariusz Brzezinski, Marcin Kowiel, Zbigniew Dauter, Bernhard Rupp, Alexander Wlodawer, Mariusz Jaskolski, Wladek Minor
Publikováno v:
IUCrJ, Vol 8, Iss 3, Pp 395-407 (2021)
As part of the global mobilization to combat the present pandemic, almost 100 000 COVID-19-related papers have been published and nearly a thousand models of macromolecules encoded by SARS-CoV-2 have been deposited in the Protein Data Bank within les
Externí odkaz:
https://doaj.org/article/e19ec1f7d95c4318919a6c73913467c7
Autor:
Mariusz Jaskolski, Zbigniew Dauter, Ivan G. Shabalin, Miroslaw Gilski, Dariusz Brzezinski, Marcin Kowiel, Bernhard Rupp, Alexander Wlodawer
Publikováno v:
IUCrJ, Vol 8, Iss 2, Pp 238-256 (2021)
The appearance at the end of 2019 of the new SARS-CoV-2 coronavirus led to an unprecedented response by the structural biology community, resulting in the rapid determination of many hundreds of structures of proteins encoded by the virus. As part of
Externí odkaz:
https://doaj.org/article/47485dd18ab647e7b2029b71252f82f0
Autor:
Shin-ichiro Hattori, Nobuyo Higashi-Kuwata, Hironori Hayashi, Srinivasa Rao Allu, Jakka Raghavaiah, Haydar Bulut, Debananda Das, Brandon J. Anson, Emma K. Lendy, Yuki Takamatsu, Nobutoki Takamune, Naoki Kishimoto, Kazutaka Murayama, Kazuya Hasegawa, Mi Li, David A. Davis, Eiichi N. Kodama, Robert Yarchoan, Alexander Wlodawer, Shogo Misumi, Andrew D. Mesecar, Arun K. Ghosh, Hiroaki Mitsuya
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Here, using in vitro assays and structural analysis, the authors characterize the anti-SARS-CoV-2 properties of two small molcules, showing these to bind and target the virus main protease (Mpro), and to exhibit a synergistic antiviral effect when co
Externí odkaz:
https://doaj.org/article/86d3e81f7e794c15baedd9ad9a968412
Autor:
Alexander Wlodawer
Publikováno v:
FEBS Open Bio, Vol 12, Iss 9, Pp 1562-1563 (2022)
It is hard to overestimate the influence of the COVID‐19 pandemic on scientific research in the last two and a half years. Within a few weeks after the first cases of the disease were reported, the causative agent, now known as SARS‐CoV‐2, was
Externí odkaz:
https://doaj.org/article/8cbc9ca32f2a4550982a087ad6b69d20
Autor:
Giuseppe Cimicata, Gil Fridkin, Tanaya Bose, Zohar Eyal, Yehuda Halfon, Elinor Breiner-Goldstein, Tara Fox, Ella Zimmerman, Anat Bashan, Natalia de Val, Alexander Wlodawer, Ada Yonath
Publikováno v:
mBio, Vol 13, Iss 2 (2022)
ABSTRACT The ribosome, a multicomponent assembly consisting of RNA and proteins, is a pivotal macromolecular machine that translates the genetic code into proteins. The large ribosomal subunit rRNA helix 68 (H68) is a key element in the protein synth
Externí odkaz:
https://doaj.org/article/d0fed25417f0439887632ec8537d4997