Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Alexander, Treiber"'
Autor:
Benjamin Berger, Priska Kaufmann, Matthias Berse, Alexander Treiber, Nathalie Grignaschi, Jasper Dingemanse
Publikováno v:
Pharmacology Research & Perspectives, Vol 11, Iss 5, Pp n/a-n/a (2023)
Abstract Nivasorexant, a selective orexin‐1‐receptor antagonist, has recently been assessed in the treatment of humans with binge‐eating disorder. Herein, the inhibitory potential of nivasorexant on cytochromes P450 (CYPs) 2C9, 2C19, and 3A4 wa
Externí odkaz:
https://doaj.org/article/3ffceb691d5245a0aeb84dd8b7b86a13
Autor:
Alexander Treiber, Stephane Delahaye, Aude Weigel, Päivi Aeänismaa, John Gatfield, Swen Seeland
Publikováno v:
Xenobiotica. :1-11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2930e1c9e76ec63d4baf47c3aa3dfeda
https://doi.org/10.1080/00498254.2023.2183159
https://doi.org/10.1080/00498254.2023.2183159
Publikováno v:
Pharmacology Research & Perspectives, Vol 8, Iss 4, Pp n/a-n/a (2020)
Abstract The dual endothelin receptor antagonist macitentan was approved in 2013 for the treatment of pulmonary arterial hypertension. Macitentan is an inducer of cytochrome P450 expression in vivo in animal species but not in man. In rat and dog, ch
Externí odkaz:
https://doaj.org/article/23ca1299056044b79869c52ff6de5bc5
Autor:
Alexander Treiber, Hamed Aissaoui, Stéphane Delahaye, Sven Glutz, Julien Grimont, Claus Müller, Swen Seeland, Valérie Siefken, Christoph Boss
Publikováno v:
ChemMedChem. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::becc86a6b2e1fb82c9985bf2d82fe08e
https://doi.org/10.1002/cmdc.202300030
https://doi.org/10.1002/cmdc.202300030
Autor:
Alexander Treiber, Martin Bolli
Publikováno v:
The Medicinal Chemist's Guide to Solving ADMET Challenges ISBN: 9781788012270
The bile salt export pump (BSEP in humans, Bsep in animals) is a member of the ATP-binding cassette superfamily of transport proteins. BSEP is selectively located in the apical (canalicular) domain of hepatocytes and catalyzes the rate-limiting step
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6b749287d3a3a3b5a9a2a99ecba5a59
https://doi.org/10.1039/9781788016414-00160
https://doi.org/10.1039/9781788016414-00160
Autor:
John Gatfield, Catherine Roch, Thierry Sifferlen, Jodi T. Williams, Alexander Treiber, Christoph Boss, Martin Bolli, Christine Brotschi, Bibia Heidmann, Francois Jenck
Publikováno v:
ChemMedChem. 14:1257-1270
The orexin system plays an important role in the regulation of wakefulness. Suvorexant, a dual orexin receptor antagonist (DORA) is approved for the treatment of primary insomnia. Herein, we outline our optimization efforts toward a novel DORA. We st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b115f7c0f955cf770604ab0fdaa3d44
https://doi.org/10.1002/cmdc.201900242
https://doi.org/10.1002/cmdc.201900242
Autor:
Markus von Raumer, Bibia Heidmann, Christoph Boss, John Gatfield, Catherine Roch, Jodi T. Williams, Christine Brotschi, Alexander Treiber, Thierry Sifferlen, Gunther Schmidt
Publikováno v:
ChemMedChem. 15(23)
Since its discovery in 1998, the orexin system has been of interest to the research community as a potential therapeutic target for the treatment of sleep/wake disorders, stress and anxiety disorders, addiction or eating disorders. It consists of two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a288d5cb5ef111945479c378d0102354
https://pubmed.ncbi.nlm.nih.gov/32937014
https://pubmed.ncbi.nlm.nih.gov/32937014
Habilitationsschrift, Universität Duisburg-Essen, 2020
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=unidue___bib::d9d848a8bda1868d5adeb67ede9b3fe4
Autor:
Alexander Treiber
Greenock in Schottland, im Jahre 1999. Die Wahrheit über die grässlichen Unglücksfälle, die fast eine ganze Familie in Greenock in Schottland auslöschten, wäre vermutlich nie ans Licht gekommen. Sie wäre mit den Betroffenen in deren Gräber f
Autor:
Ralf Koberstein, Alexander Treiber, Thierry Sifferlen, Oliver Nayler, Celia Mueller, François Jenck, Walter Fischli, Martine Clozel, Daniel Bur, Hamed Aissaoui, Thomas Weller
Publikováno v:
CHIMIA, Vol 57, Iss 5 (2003)
Different techniques can be applied for the automated production of small and large compound collections. Large libraries that are often generated and tested during the lead-finding stage of a project are typically produced by solid-phase chemistry.
Externí odkaz:
https://doaj.org/article/07754431809e4a02b27b798a2523f2f5