Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Alexander, Tonevitsky"'
Autor:
Arun Everest‐Dass, Stepan Nersisyan, Hanna Maar, Victor Novosad, Jennifer Schröder‐Schwarz, Vera Freytag, Johanna L. Stuke, Mia C. Beine, Alina Schiecke, Marie‐Therese Haider, Malte Kriegs, Omar Elakad, Hanibal Bohnenberger, Lena‐Christin Conradi, Maria Raygorodskaya, Linda Krause, Mark vonItzstein, Alexander Tonevitsky, Udo Schumacher, Diana Maltseva, Daniel Wicklein, Tobias Lange
Publikováno v:
Molecular Oncology, Vol 18, Iss 1, Pp 62-90 (2024)
Hematogenous metastasis limits the survival of colorectal cancer (CRC) patients. Here, we illuminated the roles of CD44 isoforms in this process. Isoforms 3 and 4 were predominantly expressed in CRC patients. CD44 isoform 4 indicated poor outcome and
Externí odkaz:
https://doaj.org/article/c19589a2bdca416b84704f2b8e082ac3
Publikováno v:
PeerJ, Vol 12, p e16964 (2024)
Within-host infection dynamics of Omicron dramatically differs from previous variants of SARS-CoV-2. However, little is still known about which parameters of virus-cell interplay contribute to the observed attenuated replication and pathogenicity of
Externí odkaz:
https://doaj.org/article/23fb36fe92a34e2482b29c268689badc
Autor:
Tom A.P. Driedonks, Lyle H. Nyberg, Abigail Conte, Zexu Ma, Andrew Pekosz, Eduard Duban, Alexander Tonevitsky, Holger Sültmann, Andrey Turchinovich, Kenneth W. Witwer
Publikováno v:
Heliyon, Vol 10, Iss 3, Pp e24570- (2024)
RNA viruses have been shown to express various short RNAs, some of which have regulatory roles during replication, transcription, and translation of viral genomes. However, short viral RNAs generated from SARS-CoV-1 and SARS-CoV-2 genomic RNAs remain
Externí odkaz:
https://doaj.org/article/7f63fad5ebd44d9b80148db3c47fd3cb
Autor:
Diana Maltseva, Alexander Tonevitsky
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Alternative splicing is often deregulated in cancer, and cancer-specific isoform switches are part of the oncogenic transformation of cells. Accumulating evidence indicates that isoforms of the multifunctional cell-surface glycoprotein CD44 play diff
Externí odkaz:
https://doaj.org/article/85a52239a53d492ab82b26a15d7104fb
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Since its original discovery over a decade ago, extracellular RNA (exRNA) has been found in all biological fluids. Furthermore, extracellular microRNA has been shown to be involved in communication between various cell types. Importantly, the exRNA i
Externí odkaz:
https://doaj.org/article/23e4511fc58f47f49fd0f1154360d56d
Autor:
Svetlana Lebedeva, Arus Margaryan, Elena Smolyarchuk, Andrey Nedorubov, Maria Materenchuk, Alexander Tonevitsky, Kerim Mutig
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
The diabetic kidney disease (DKD) is the major cause of the chronic kidney disease (CKD). Enhanced plasma vasopressin (VP) levels have been associated with the pathophysiology of DKD and CKD. Stimulation of VP release in DKD is caused by glucose-depe
Externí odkaz:
https://doaj.org/article/1214b55d79904e69879fd135a160f458
Autor:
Vladimir Staroverov, Stepan Nersisyan, Alexei Galatenko, Dmitriy Alekseev, Sofya Lukashevich, Fedor Polyakov, Nikita Anisimov, Alexander Tonevitsky
Publikováno v:
PeerJ, Vol 11, p e14828 (2023)
Mathematical modeling is widely used to study within-host viral dynamics. However, to the best of our knowledge, for the case of SARS-CoV-2 such analyses were mainly conducted with the use of viral load data and for the wild type (WT) variant of the
Externí odkaz:
https://doaj.org/article/07cac33da9d1411a8a20aa87e41e48ed
Autor:
Maxim Shkurnikov, Stepan Nersisyan, Darya Averinskaya, Milena Chekova, Fedor Polyakov, Aleksei Titov, Dmitriy Doroshenko, Valery Vechorko, Alexander Tonevitsky
Publikováno v:
PeerJ, Vol 11, p e14707 (2023)
In mid-2021, the SARS-CoV-2 Delta variant caused the third wave of the COVID-19 pandemic in several countries worldwide. The pivotal studies were aimed at studying changes in the efficiency of neutralizing antibodies to the spike protein. However, mu
Externí odkaz:
https://doaj.org/article/88e9b0482c404d02ab62ea3d6f50d781
Autor:
Sergey Nikulin, Alexandra Razumovskaya, Andrey Poloznikov, Galina Zakharova, Boris Alekseev, Alexander Tonevitsky
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Introduction: Relapse of breast cancer is one of the key obstacles to successful treatment. Previously we have shown that low expression of ELOVL5 and IGFBP6 genes in breast cancer tissue corresponded to poor prognosis. ELOVL5 participates directly i
Externí odkaz:
https://doaj.org/article/45e23f12e8694012ba9a4373ae948097
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
A widely used procedure for selecting significant miRNA-mRNA or isomiR-mRNA pairs out of predicted interactions involves calculating the correlation between expression levels of miRNAs/isomiRs and mRNAs in a series of samples. In this manuscript, we
Externí odkaz:
https://doaj.org/article/7b6f0b2c56b743d984e5a599f4f74ba1