Zobrazeno 1 - 10
of 364
pro vyhledávání: '"Alexander, Tomasz"'
Autor:
Lilly Cheng Immergluck, Xiting Lin, Ruijin Geng, Mike Edelson, Fatima Ali, Chaohua Li, TJ Lin, Chamanara Khalida, Nancy Piper-Jenks, Maria Pardos de la Gandara, Herminia de Lencastre, Alexander Tomasz, Teresa H. Evering, Rhonda G. Kost, Roger Vaughan, Jonathan N. Tobin
Publikováno v:
Antibiotics, Vol 12, Iss 10, p 1541 (2023)
(1) Background: With increasing international travel and mass population displacement due to war, famine, climate change, and immigration, pathogens, such as Staphylococcus aureus (S. aureus), can also spread across borders. Methicillin-resistant S.
Externí odkaz:
https://doaj.org/article/4f31308dd1834364a0c42a98cbf75344
Autor:
Raquel Portela, Nuno A. Faria, Michael Mwangi, Maria Miragaia, Hermínia de Lencastre, Alexander Tomasz, Rita Gonçalves Sobral
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 5 (2022)
ABSTRACT In a study of antibiotic resistance in Staphylococcus aureus, specific cell wall mutants were previously generated for the peptidoglycan biosynthesis gene murF, by the insertion of an integrative plasmid. A collection of 30 independent mutan
Externí odkaz:
https://doaj.org/article/321a89e2d0b04451bb4b28984ae2b1f0
Publikováno v:
Antibiotics, Vol 11, Iss 2, p 255 (2022)
The acquisition of the resistance determinant mecA by Staphylococcus aureus is of major clinical importance, since it confers a resistant phenotype to virtually the entire large family of structurally diverse β-lactam antibiotics. While the common r
Externí odkaz:
https://doaj.org/article/44c3afe5a0fc402aa5c06a9d0d3cba0f
Autor:
Jonathan N. Tobin, Suzanne Hower, Brianna M. D’Orazio, María Pardos de la Gándara, Teresa H. Evering, Chamanara Khalida, Jessica Ramachandran, Leidy Johana González, Rhonda G. Kost, Kimberly S. Vasquez, Hermínia de Lencastre, Alexander Tomasz, Barry S. Coller, Roger Vaughan
Publikováno v:
Antibiotics, Vol 10, Iss 9, p 1105 (2021)
Recurrent skin and soft tissue infections (SSTI) caused by Community-Associated Methicillin-Resistant Staphylococcus aureus (CA-MRSA) or Methicillin-Sensitive Staphylococcus aureus (CA-MSSA) present treatment challenges. This community-based trial ex
Externí odkaz:
https://doaj.org/article/9620b4e299a94ba590d2d35c5dd60ac7
Autor:
Catriona P. Harkins, Bruno Pichon, Michel Doumith, Julian Parkhill, Henrik Westh, Alexander Tomasz, Herminia de Lencastre, Stephen D. Bentley, Angela M. Kearns, Matthew T. G. Holden
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-11 (2017)
Abstract Background The spread of drug-resistant bacterial pathogens poses a major threat to global health. It is widely recognised that the widespread use of antibiotics has generated selective pressures that have driven the emergence of resistant s
Externí odkaz:
https://doaj.org/article/f93dfb3549844449b10c259373c1b5b0
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0199707 (2018)
Addition of β-lactam antibiotics to growing cultures of bacteria inhibit synthesis of the bacterial cell wall peptidoglycan accompanied by killing (loss of viable titer) and lysis (physical disintegration) of the cells. However, it has also been wel
Externí odkaz:
https://doaj.org/article/2067e210a6f1463b96628ccb68a4c82c
Autor:
Joana Rolo, Peder Worning, Jesper Boye Nielsen, Rita Sobral, Rory Bowden, Ons Bouchami, Peter Damborg, Luca Guardabassi, Vincent Perreten, Henrik Westh, Alexander Tomasz, Hermínia de Lencastre, Maria Miragaia
Publikováno v:
PLoS Genetics, Vol 13, Iss 4, p e1006674 (2017)
The epidemiologically most important mechanism of antibiotic resistance in Staphylococcus aureus is associated with mecA-an acquired gene encoding an extra penicillin-binding protein (PBP2a) with low affinity to virtually all β-lactams. The introduc
Externí odkaz:
https://doaj.org/article/7531cc90ac664bd3be298f8caa8c2183
Autor:
Maria Pardos de la Gandara, Marie Curry, Judith Berger, David Burstein, Phyllis Della-Latta, Virgina Kopetz, John Quale, Eric Spitzer, Rexie Tan, Carl Urban, Guiqing Wang, Susan Whittier, Herminia de Lencastre, Alexander Tomasz
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0156924 (2016)
A surveillance study in 1996 identified the USA100 clone (ST5/SCCmecII)-also known as the "New York/Japan" clone-as the most prevalent MRSA causing infections in 12 New York City hospitals. Here we update the epidemiology of MRSA in seven of the same
Externí odkaz:
https://doaj.org/article/3bd4aa7f039a4dba9a1897309aac06ac
Autor:
Maria Pardos de la Gandara, Christopher E Cheleuitte-Nieves, Leslie Lynn Diaz, Chad W. Euler, Alejandra Gonzalez, Winrich A. Freiwald, Hermínia M de Lencastre, Alexander Tomasz
Publikováno v:
Comparative Medicine. 70:335-347
Lytic enzymes are novel antimicrobial agents that degrade bacterial cell walls, resulting in cell rupture and death. We tested one enzyme, the bacteriocin lysostaphin, for treatment of nonhuman primates (Macaca mulatta) with persistent methicillinres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::777a22fbde23e9580b075528dd0efd2e
https://doi.org/10.30802/aalas-cm-19-000102
https://doi.org/10.30802/aalas-cm-19-000102
Autor:
Brianna M. D’Orazio, Jonathan N. Tobin, Rhonda G. Kost, Chamanara Khalida, Jessica Ramachandran, Mina Pastagia, Teresa H. Evering, Maria P. de la Gandara, Cameron Coffran, Joel Correa da Rosa, Kimberly Vasquez, Getaw W. Hassen, Franco Barsanti, Satoko Kanahara, Regina Hammock, Rosalee Nguyen, Mark Trezia, Trang Gisler, Herminia de Lencastre, Alexander Tomasz, Barry S. Coller
Publikováno v:
Journal of Clinical and Translational Science, Vol 2, Pp 71-71 (2018)
OBJECTIVES/SPECIFIC AIMS: Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) skin and soft tissue infections (SSTIs) recurrence ranges from 16% to 43% and presents significant challenges to clinicians, patients, and families.
Externí odkaz:
https://doaj.org/article/b5a9f22aa99e4270a0b8344483b8283c