Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Alexander, Stoye"'
Autor:
Elinor Hortle, David I. Roper, Warwick J. Britton, Richard J. Payne, Gregory M. Cook, Wendy Tran, Paige M. E. Hawkins, Alexander Stoye, Christopher G. Dowson, Rebecca E Audette, Thomas Balle, Jessica L. Ochoa, Gayathri Nagalingam, Daniel J Ford, Ali Saad Kusay, Venugopal Pujari, Roger G. Linington, Chen-Yi Cheung, Dean C. Crick, Eric J. Rubin, Stefan H. Oehlers, Susan A. Charman
Publikováno v:
Journal of Medicinal Chemistry. 64:17326-17345
Herein, we report the design and synthesis of inhibitors of Mycobacterium tuberculosis (Mtb) phospho-MurNAc-pentapeptide translocase I (MurX), the first membrane-associated step of peptidoglycan synthesis, leveraging the privileged structure of the s
Autor:
Anthony J. O’Donoghue, Michael C Yoon, Max J. Bedding, Vivian Hook, Pavla Fajtová, Arthur H Tang, Mark Larance, Linfeng Li, Chien-Te Tseng, Stuart Turville, James H. McKerrow, Dustin Pwee, Laura Beretta, Alexander Stoye, Danielle E. Skinner, William H. Gerwick, Anneliese S. Ashhurst, Thomas D. Meek, Anupriya Aggarwal, Aleksandra Drelich, Richard J. Payne
Publikováno v:
bioRxiv
Cathepsin L is a key host cysteine protease utilized by coronaviruses for cell entry and is a promising drug target for novel antivirals against SARS-CoV-2. The marine natural product gallinamide A and several synthetic analogues were identified as p
Intramolecular Interactions Enhance the Potency of Gallinamide A Analogues against Trypanosoma cruzi
Autor:
Elany Barbosa Da Silva, Vandna Sharma, Lilian Hernandez-Alvarez, Arthur H. Tang, Alexander Stoye, Anthony J. O’Donoghue, William H. Gerwick, Richard J. Payne, James H. McKerrow, Larissa M. Podust
Publikováno v:
Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Made available in DSpace on 2022-04-29T08:40:33Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-03-10 Gallinamide A, a metabolite of the marine cyanobacterium Schizothrix sp., selectively inhibits cathepsin L-like cysteine proteases. We evalua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cdb5fecb14e1c1a13eb99c8c001679f
Autor:
Elany, Barbosa Da Silva, Vandna, Sharma, Lilian, Hernandez-Alvarez, Arthur H, Tang, Alexander, Stoye, Anthony J, O'Donoghue, William H, Gerwick, Richard J, Payne, James H, McKerrow, Larissa M, Podust
Publikováno v:
Journal of medicinal chemistry. 65(5)
Gallinamide A, a metabolite of the marine cyanobacterium
Autor:
Elany Barbosa Da Silva, Vandna Sharma, Lilian Hernandez-Alvarez, Arthur H. Tang, Alexander Stoye, Anthony J. O’Donoghue, William H. Gerwick, Richard J. Payne, James H. McKerrow, Larissa M. Podust
Gallinamide A, a metabolite of the marine cyanobacterium Schizothrix sp., selectively inhibits cathepsin L-like cysteine proteases. We evaluated potency of gallinamide A and 23 synthetic analogs against intracellular Trypanosoma cruzi amastigotes and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f77475f716d1b751ccf5823a16a0a16e
https://doi.org/10.1101/2021.12.22.473926
https://doi.org/10.1101/2021.12.22.473926
Autor:
Wendy, Tran, Ali S, Kusay, Paige M E, Hawkins, Chen-Yi, Cheung, Gayathri, Nagalingam, Venugopal, Pujari, Daniel J, Ford, Alexander, Stoye, Jessica L, Ochoa, Rebecca E, Audette, Elinor, Hortle, Stefan H, Oehlers, Susan A, Charman, Roger G, Linington, Eric J, Rubin, Christopher G, Dowson, David I, Roper, Dean C, Crick, Thomas, Balle, Gregory M, Cook, Warwick J, Britton, Richard J, Payne
Publikováno v:
Journal of medicinal chemistry. 64(23)
Herein, we report the design and synthesis of inhibitors of
Autor:
Anneliese S, Ashhurst, Arthur H, Tang, Pavla, Fajtová, Michael, Yoon, Anupriya, Aggarwal, Alexander, Stoye, Mark, Larance, Laura, Beretta, Aleksandra, Drelich, Danielle, Skinner, Linfeng, Li, Thomas D, Meek, James H, McKerrow, Vivian, Hook, Chien-Te K, Tseng, Stuart, Turville, William H, Gerwick, Anthony J, O'Donoghue, Richard J, Payne
Publikováno v:
Journal of Medicinal Chemistry
Cathepsin L is a key host cysteine protease utilized by coronaviruses for cell entry and is a promising drug target for novel antivirals against SARS-CoV-2. The marine natural product gallinamide A and several synthetic analogues were identified as p
Autor:
Richard J. Payne, William H. Gerwick, Michael Yoon, Alexander Stoye, James H. McKerrow, Pavla Fajtová, Laura Beretta, Stuart Turville, Aleksandra Drelich, Vivian Hook, Anthony J. O’Donoghue, Chien-Te K Tseng, Danielle E. Skinner, Anneliese S. Ashhurst, Thomas D. Meek, Anupriya Aggarwal, Mark Larance, Arthur H Tang, Linfeng Li
The emergence of SARS-CoV-2 in late 2019, and the subsequent COVID-19 pandemic, has led to substantial mortality, together with mass global disruption. There is an urgent need for novel antiviral drugs for therapeutic or prophylactic application. Cat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b70db97c0f9f0ceb08f5cd8ca69a321
https://doi.org/10.1101/2020.12.23.424111
https://doi.org/10.1101/2020.12.23.424111
Autor:
Alexander Stoye, Horst Kunz
Publikováno v:
Topics in Heterocyclic Chemistry ISBN: 9783030453039
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d0535d899ed8a8986957f5797c5eebe
https://doi.org/10.1007/7081_2020_37
https://doi.org/10.1007/7081_2020_37
Publikováno v:
Acta Crystallographica Section E, Vol 66, Iss 12, Pp o3343-o3343 (2010)
The crystal structure of the title compound, C21H22N2O2S, shows a network of N—H...N and N—H...O hydrogen bonds. The tolyl and 1-phenyl rings are almost mutually coplanar [7.89 (9)°], while the 2-phenyl ring makes a dihedral angle of 50.8 (1) °
Externí odkaz:
https://doaj.org/article/12cb9b25c4c0459fb8f8518fa1660b36