Zobrazeno 1 - 10
of 154
pro vyhledávání: '"Alexander, Sorkin"'
Autor:
Mirella Mourad, Taylor Jacob, Elena Sadovsky, Shai Bejerano, Glicella Salazar-De Simone, Tarique Rajasaheb Bagalkot, Jason Zucker, Michael T. Yin, Jennifer Y. Chang, Lihong Liu, Larisa Debelenko, Carrie J. Shawber, Morgan Firestein, Yingshi Ouyang, Cynthia Gyamfi-Bannerman, Anna Penn, Alexander Sorkin, Ronald Wapner, Yoel Sadovsky
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract The coronavirus disease 2019 (COVID-19) pandemic affected people at all ages. Whereas pregnant women seemed to have a worse course of disease than age-matched non-pregnant women, the risk of feto-placental infection is low. Using a cohort of
Externí odkaz:
https://doaj.org/article/90b2da73fe7842b7ac25cfe6e96cbaef
Autor:
Mireia Perez Verdaguer, Tian Zhang, Sachin Surve, Joao A. Paulo, Callen Wallace, Simon C. Watkins, Steven P. Gygi, Alexander Sorkin
Publikováno v:
Cell Reports, Vol 39, Iss 11, Pp 110950- (2022)
Summary: Ligand binding to the EGF receptor (EGFR) triggers multiple signal-transduction processes and promotes endocytosis of the receptor. The mechanisms of EGFR endocytosis and its cross-talk with signaling are poorly understood. Here, we combine
Externí odkaz:
https://doaj.org/article/c7e9d8eaac494af3a45d6223d1c2d314
Autor:
Sachin Surve, Alexander Sorkin
Publikováno v:
Bio-Protocol, Vol 12, Iss 10 (2022)
Subcellular localization dynamics of proteins involved in signal transduction processes is crucial in determining the signaling outcome. However, there is very limited information about the localization of endogenous signaling proteins in living cell
Externí odkaz:
https://doaj.org/article/889ec2db89b74c419066b7b39b65ecab
Autor:
Yingshi Ouyang, Tarique Bagalkot, Wendy Fitzgerald, Elena Sadovsky, Tianjiao Chu, Ana Martínez-Marchal, Miguel Brieño-Enríquez, Emily J. Su, Leonid Margolis, Alexander Sorkin, Yoel Sadovsky
Publikováno v:
mSphere, Vol 6, Iss 2 (2021)
Pregnant women worldwide have been affected by COVID-19. As the virus is commonly spread to various organs via the bloodstream and because human placental trophoblasts are directly bathed in maternal blood, feto-placental infection by SARS-CoV-2 seem
Externí odkaz:
https://doaj.org/article/faec019395214c4a859b6fdf1f72c9d8
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Dopamine transporter (DAT) has been shown to accumulate in filopodia in neurons and non-neuronal cells. To examine the mechanisms of DAT filopodial targeting, we used quantitative live-cell fluorescence microscopy, and compared the effects o
Externí odkaz:
https://doaj.org/article/712ba815e1554d59aab2ad3df60977dc
Autor:
Hui Li, Itziar Pinilla-Macua, Yingshi Ouyang, Elena Sadovsky, Kazuhiro Kajiwara, Alexander Sorkin, Yoel Sadovsky
Publikováno v:
Journal of Extracellular Vesicles, Vol 9, Iss 1 (2020)
Pregnancy is a unique situation, in which placenta-derived small extracellular vesicles (sEVs) may communicate with maternal and foetal tissues. While relevant to homoeostatic and pathological functions, the mechanisms underlying sEV entry and cargo
Externí odkaz:
https://doaj.org/article/4f505119cb834da0b454f1c24b76d510
Autor:
Mads Breum Larsen, Mireia Perez Verdaguer, Brigitte F Schmidt, Marcel P Bruchez, Simon C Watkins, Alexander Sorkin
Publikováno v:
eLife, Vol 8 (2019)
Previously we used gene-editing to label endogenous EGF receptor (EGFR) with GFP and demonstrate that picomolar concentrations of EGFR ligand drive signaling and endocytosis of EGFR in tumors in vivo (Pinilla-Macua et al., 2017). We now use gene-edit
Externí odkaz:
https://doaj.org/article/ff22768ff9c84a719bbb4e8178a8f07b
Autor:
Tarique Bagalkot, Alexander Sorkin
Publikováno v:
bioRxiv
Dopamine transporter (DAT) controls dopamine signaling in the brain through the reuptake of synaptically released dopamine. DAT is a target of abused psychostimulants such as amphetamine (Amph). Acute Amph is proposed to cause transient DAT endocytos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faed6bf24eed4833ef1f0ce0e1a56ff3
https://doi.org/10.1101/2023.05.17.541165
https://doi.org/10.1101/2023.05.17.541165
Autor:
Irene Estadella, Oriol Pedrós-Gámez, Magalí Colomer-Molera, Manel Bosch, Alexander Sorkin, Antonio Felipe
Publikováno v:
Cells, Vol 9, Iss 8, p 1833 (2020)
Ion channels (IChs) are transmembrane proteins that selectively drive ions across membranes. The function of IChs partially relies on their abundance and proper location in the cell, fine-tuned by the delicate balance between secretory, endocytic, an
Externí odkaz:
https://doaj.org/article/5230e6c3776f44f0b9b10fb9fbaaa366
Publikováno v:
eLife, Vol 7 (2018)
Clathrin-independent endocytosis (CIE) mediates internalization of many transmembrane proteins but the mechanisms of cargo recruitment during CIE are poorly understood. We found that the cell-permeable furopyrimidine AIM-100 promotes dramatic oligome
Externí odkaz:
https://doaj.org/article/d1d162cc637440c99aa9bd3bac0994b8