Zobrazeno 1 - 10
of 178
pro vyhledávání: '"Alexander, Scheffold"'
Autor:
Patience N. Eschenhagen, Petra Bacher, Claudia Grehn, Jochen G. Mainz, Alexander Scheffold, Carsten Schwarz
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background: Together with impaired mucociliary clearance, lung disease in cystic fibrosis (CF) is driven by dysregulation of innate and adaptive immunity caused by dysfunctional CFTR (Cystic Fibrosis Transmembrane Conductance Regulator), leading to a
Externí odkaz:
https://doaj.org/article/09cb2c66fa0b4caa98b0e6a7897dbe5a
Autor:
Carsten Schwarz, Patience Eschenhagen, Henrijette Schmidt, Thordis Hohnstein, Christina Iwert, Claudia Grehn, Jobst Roehmel, Eva Steinke, Mirjam Stahl, Laura Lozza, Ekaterina Tikhonova, Elisa Rosati, Ulrik Stervbo, Nina Babel, Jochen G. Mainz, Hilmar Wisplinghoff, Frank Ebel, Lei-Jie Jia, Matthew G. Blango, Peter Hortschansky, Sascha Brunke, Bernhard Hube, Axel A. Brakhage, Olaf Kniemeyer, Alexander Scheffold, Petra Bacher
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 5 (2023)
BACKGROUND The fungus Aspergillus fumigatus causes a variety of clinical phenotypes in patients with cystic fibrosis (pwCF). Th cells orchestrate immune responses against fungi, but the types of A. fumigatus–specific Th cells in pwCF and their cont
Externí odkaz:
https://doaj.org/article/952a35bb46204b4d99016140937e7c30
Autor:
Javier Ibanez, Rolf Fendel, Freia-Raphaella Lorenz, Patricia Granados-Bayon, Sina Brückner, Meral Esen, Mihály Sulyok, Zita Sulyok, Steffen Borrmann, Petra Bacher, Alexander Scheffold, Stephen L. Hoffman, Peter G. Kremsner, Benjamin Mordmüller
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-11 (2022)
Abstract Repeated direct venous inoculation of Plasmodium falciparum sporozoites (PfSPZ) together with antimalarial chemoprophylaxis (PfSPZ–CVac) is the most potent way to induce sterile immunity against P. falciparum infection in malaria-naive vol
Externí odkaz:
https://doaj.org/article/557ad6c72b20435e92085c01ea4d8799
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Immunophenotyping on the molecular and cellular level is a central aspect for characterization of patients with inflammatory diseases, both to better understand disease etiopathogenesis and based on this to develop diagnostic and prognostic biomarker
Externí odkaz:
https://doaj.org/article/9c2e7f0d61bd446b8960bd6310295262
Autor:
Caren Ramien, Erik C. Yusko, Jan Broder Engler, Stefanie Gamradt, Kostas Patas, Nils Schweingruber, Anne Willing, Sina Cathérine Rosenkranz, Anke Diemert, Anja Harrison, Marissa Vignali, Catherine Sanders, Harlan S. Robins, Eva Tolosa, Christoph Heesen, Petra C. Arck, Alexander Scheffold, Kenneth Chan, Ryan O. Emerson, Manuel A. Friese, Stefan M. Gold
Publikováno v:
Cell Reports, Vol 29, Iss 4, Pp 810-815.e4 (2019)
Summary: Identifying T cell clones associated with human autoimmunity has remained challenging. Intriguingly, many autoimmune diseases, including multiple sclerosis (MS), show strongly diminished activity during pregnancy, providing a unique research
Externí odkaz:
https://doaj.org/article/4927d90c64d54853afb018bd904b32d8
Autor:
Vera Voltersen, Matthew G. Blango, Sahra Herrmann, Franziska Schmidt, Thorsten Heinekamp, Maria Strassburger, Thomas Krüger, Petra Bacher, Jasmin Lother, Esther Weiss, Kerstin Hünniger, Hong Liu, Peter Hortschansky, Alexander Scheffold, Jürgen Löffler, Sven Krappmann, Sandor Nietzsche, Oliver Kurzai, Hermann Einsele, Olaf Kniemeyer, Scott G. Filler, Utz Reichard, Axel A. Brakhage
Publikováno v:
mBio, Vol 9, Iss 5 (2018)
ABSTRACT Aspergillus fumigatus is a common airborne fungal pathogen of humans and a significant source of mortality in immunocompromised individuals. Here, we provide the most extensive cell wall proteome profiling to date of A. fumigatus resting con
Externí odkaz:
https://doaj.org/article/9fe5a0ecbee347959685d1702c23f58a
Autor:
Felix C. Koehler, Oliver A. Cornely, Hilmar Wisplinghoff, Astrid C. Schauss, Jon Salmanton-Garcia, Helmut Ostermann, Maren Ziegler, Petra Bacher, Alexander Scheffold, Regina Alex, Anne Richter, Philipp Koehler
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Background: Blood or tissue culture or histology prove invasive Candida infection, but long time to result, limited feasibility and sensitivity call for new approaches. In this pilot project, we describe the diagnostic potential of quantitating Candi
Externí odkaz:
https://doaj.org/article/129e6ff20e884ba58a0b8ebfe802a62e
Autor:
Anna Nowak, Dominik Lock, Petra Bacher, Thordis Hohnstein, Katrin Vogt, Judith Gottfreund, Pascal Giehr, Julia K. Polansky, Birgit Sawitzki, Andrew Kaiser, Jörn Walter, Alexander Scheffold
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Regulatory T cells (Tregs) are an attractive therapeutic tool for several different immune pathologies. Therapeutic Treg application often requires prolonged in vitro culture to generate sufficient Treg numbers or to optimize their functionality, e.g
Externí odkaz:
https://doaj.org/article/e7874dcbe1cb4db2b548ec313aecd489
Autor:
Ira Ekmekciu, Eliane von Klitzing, Christian Neumann, Petra Bacher, Alexander Scheffold, Stefan Bereswill, Markus M. Heimesaat
Publikováno v:
Frontiers in Microbiology, Vol 8 (2017)
The essential role of the intestinal microbiota in the well-functioning of host immunity necessitates the investigation of species-specific impacts on this interplay. Aim of this study was to examine the ability of defined Gram-positive and Gram-nega
Externí odkaz:
https://doaj.org/article/9f570a6a5e1641588b16f6ff8469aeec
