Zobrazeno 1 - 10
of 234
pro vyhledávání: '"Alexander, Poltorak"'
Autor:
David Jetton, Hayley I. Muendlein, Wilson M. Connolly, Zoie Magri, Irina Smirnova, Rebecca Batorsky, Joan Mecsas, Alexei Degterev, Alexander Poltorak
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114641- (2024)
Summary: Caspase-8-dependent pyroptosis has been shown to mediate host protection from Yersinia infection. For this mode of cell death, the kinase activity of receptor-interacting protein kinase 1 (RIPK1) is required, but the autophosphorylation site
Externí odkaz:
https://doaj.org/article/8f76fc38478046edb57e8621e9f53391
Autor:
Hayley I. Muendlein, Wilson M. Connolly, Zoie Magri, Irina Smirnova, Vladimir Ilyukha, Avishekh Gautam, Alexei Degterev, Alexander Poltorak
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Yersiania YopJ protein has been shown to drive caspase-8-mediated pyroptosis. Here the authors show a precise mechanism of this non-canonical cell death pathway that is controlled by a TRIF-dependent complex of FADD, RIPK1, caspase-8 and ZBP1.
Externí odkaz:
https://doaj.org/article/c23eacb750254746b5eeb2cdfdaf0689
Autor:
Alexander Poltorak
Publikováno v:
Frontiers in Human Neuroscience, Vol 15 (2021)
Brain states, which correlate with specific motor, cognitive, and emotional states, may be monitored with noninvasive techniques such as electroencephalography (EEG) and magnetoencephalography (MEG) that measure macroscopic cortical activity manifest
Externí odkaz:
https://doaj.org/article/3b74c8080a1d4d00ae578658d6252ed0
Autor:
Marina Anastasiou, Gail A. Newton, Kuljeet Kaur, Francisco J. Carrillo-Salinas, Sasha A. Smolgovsky, Abraham L. Bayer, Vladimir Ilyukha, Shruti Sharma, Alexander Poltorak, Francis W. Luscinskas, Pilar Alcaide
Publikováno v:
JCI Insight, Vol 6, Iss 15 (2021)
The stimulator of IFN genes (STING) protein senses cyclic dinucleotides released in response to double-stranded DNA and functions as an adaptor molecule for type I IFN (IFNI) signaling by activating IFNI-stimulated genes (ISG). We found impaired T ce
Externí odkaz:
https://doaj.org/article/416b3de649144e29a5509b756c42a295
Autor:
Hayley I. Muendlein, Joseph Sarhan, Beiyun C. Liu, Wilson M. Connolly, Stephen A. Schworer, Irina Smirnova, Amy Y. Tang, Vladimir Ilyukha, Jodie Pietruska, Soroush Tahmasebi, Nahum Sonenberg, Alexei Degterev, Alexander Poltorak
Publikováno v:
Cell Reports, Vol 30, Iss 3, Pp 699-713.e4 (2020)
Summary: Receptor-interacting protein kinase 1 (RIPK1) and 3 (RIPK3) are well known for their capacity to drive necroptosis via mixed-lineage kinase-like domain (MLKL). Recently, RIPK1/3 kinase activity has been shown to drive inflammation via activa
Externí odkaz:
https://doaj.org/article/b14db846e8cc4f8c8f65d98ff6c63481
Autor:
Hayley I. Muendlein, Wilson M. Connolly, James Cameron, David Jetton, Zoie Magri, Irina Smirnova, Edouard Vannier, Xudong Li, Amanda J. Martinot, Rebecca Batorsky, Alexander Poltorak
Publikováno v:
Sci Immunol
TNF mediates a variety of biological processes including cellular proliferation, inflammatory responses, and cell death and is therefore associated with numerous pathologies including autoinflammatory diseases and septic shock. The inflammatory and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae9307eb3fde09c39761121d8bf642ad
https://doi.org/10.1126/sciimmunol.add0665
https://doi.org/10.1126/sciimmunol.add0665
Autor:
Beiyun C. Liu, Joseph Sarhan, Alexander Panda, Hayley I. Muendlein, Vladimir Ilyukha, Jörn Coers, Masahiro Yamamoto, Ralph R. Isberg, Alexander Poltorak
Publikováno v:
Cell Reports, Vol 24, Iss 1, Pp 155-168.e5 (2018)
Summary: Legionella pneumophila elicits caspase-11-driven macrophage pyroptosis through guanylate-binding proteins (GBPs) encoded on chromosome 3. It has been proposed that microbe-driven IFN upregulates GBPs to facilitate pathogen vacuole rupture an
Externí odkaz:
https://doaj.org/article/217eebaf70ed4ee88874c232373dfad4
Autor:
Daniil Nikitin, Dmitry Penzar, Andrew Garazha, Maxim Sorokin, Victor Tkachev, Nicolas Borisov, Alexander Poltorak, Vladimir Prassolov, Anton A. Buzdin
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Endogenous retroviruses and retrotransposons also termed retroelements (REs) are mobile genetic elements that were active until recently in human genome evolution. REs regulate gene expression by actively reshaping chromatin structure or by directly
Externí odkaz:
https://doaj.org/article/6d9cc36de1164356b8f1d1e9e82516e2
Autor:
Alexander Poltorak
Publikováno v:
Current biology : CB. 32(16)
Mitochondria are central to apoptosis, an immunologically silent form of cell death. The mitochondrial, or 'intrinsic', apoptotic pathway is activated when the permeabilized mitochondrial membrane of stressed cells releases apoptotic effectors. A new
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b15941524cd1b63bf51a8a8ffa2018a
https://pubmed.ncbi.nlm.nih.gov/35907404
https://pubmed.ncbi.nlm.nih.gov/35907404
Autor:
Hayley I. Muendlein, Wilson M. Connolly, Zoie Magri, David Jetton, Irina Smirnova, Alexei Degterev, Siddharth Balachandran, Alexander Poltorak
Publikováno v:
Proceedings of the National Academy of Sciences. 119
ZBP1 is widely recognized as a mediator of cell death for its role in initiating necroptotic, apoptotic, and pyroptotic cell death pathways in response to diverse pathogenic infection. Herein, we characterize an unanticipated role for ZBP1 in promoti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56658ecc0d309b1806e4791bec5acaf2
https://doi.org/10.1073/pnas.2113872119
https://doi.org/10.1073/pnas.2113872119