Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Alexander, Pflug"'
Autor:
Philipp Pieroh, Tim Hohmann, Florian Gras, Sven Märdian, Alexander Pflug, Silvan Wittenberg, Christoph Ihle, Notker Blankenburg, Kevin Dallacker-Losensky, Tanja Schröder, Steven C. Herath, Hans-Georg Palm, Christoph Josten, Fabian M. Stuby, Daniel Wagner, Andreas Höch
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Treatment recommendations for fragility fractures of the pelvis (FFP) have been provided along with the good reliable FFP classification but they are not proven in large studies and recent reports challenge these recommendations. Thus, we ai
Externí odkaz:
https://doaj.org/article/29a1cf56a2764308a727a0766ed0c2e3
Autor:
Tim Krischuns, Catherine Isel, Petra Drncova, Maria Lukarska, Alexander Pflug, Sylvain Paisant, Vincent Navratil, Stephen Cusack, Nadia Naffakh
Publikováno v:
PLoS Pathogens, Vol 18, Iss 5, p e1010328 (2022)
During annual influenza epidemics, influenza B viruses (IBVs) co-circulate with influenza A viruses (IAVs), can become predominant and cause severe morbidity and mortality. Phylogenetic analyses suggest that IAVs (primarily avian viruses) and IBVs (p
Externí odkaz:
https://doaj.org/article/cde8c4d7d9d74d3b849516543866cee9
Autor:
Lucy V. Edwardes, Sarah J. Caswell, Mariacarmela Giurrandino, Xiang Zhai, Andrea Gohlke, Demetrios H. Kostomiris, Hannah K. Pollard, Alexander Pflug, Gregory R. Hamm, Kate V. Jervis, Paul N. Clarkson, Karl Syson
Publikováno v:
Biochemistry. 61:1974-1987
Human lysine methyltransferase 2D (hKMT2D) is an epigenetic writer catalyzing the methylation of histone 3 lysine 4. hKMT2D by itself has little catalytic activity and reaches full activation as part of the WRAD2 complex, additionally comprising bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4381a5f29cee7d23fa10c29cca9377de
https://doi.org/10.1021/acs.biochem.2c00385
https://doi.org/10.1021/acs.biochem.2c00385
Autor:
Edward J. Hennessy, Marianne Schimpl, Emma Rivers, Paul D. Smith, Elizabeth Hardaker, Ann T. Doherty, Nichola L. Davies, Jon Travers, Qianxiu Zhu, Beth Williamson, Graham Smith, Lorraine Mooney, Helen Musgrove, Kristin Goldberg, Muireann Coen, Anne-Laure Lainé, Xiefeng Jiang, Philip Hopcroft, Yuting Zheng, Robert I Troup, George Hodgson, Nicola Lindsay, Lindsay McMurray, Olga Collingwood, Stephen D. Wilkinson, Sharon Tentarelli, Guang He, Philip B. Rawlins, Roshini Markandu, Jon Winter-Holt, Josephine Walton, Ankur Karmokar, J. Willem M. Nissink, Yumeng Mao, Dejian Yang, Alexander Pflug, Gary Fairley, Scott Boyd, Cheng Wang, Anne Jackson, Martin R. Brown, William McCoull, Neville McLean, Venkatesh Pilla Reddy
Publikováno v:
Journal of Medicinal Chemistry. 64:13524-13539
Inhibition of Mer and Axl kinases has been implicated as a potential way to improve the efficacy of current immuno-oncology therapeutics by restoring the innate immune response in the tumor microenvironment. Highly selective dual Mer/Axl kinase inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae4c719e098004f12a5992670f8e8abc
https://doi.org/10.1021/acs.jmedchem.1c00920
https://doi.org/10.1021/acs.jmedchem.1c00920
Autor:
William McCoull, Jon Winter-Holt, Marianne Schimpl, Elizabeth Underwood, Ross Overman, Juli Warwicker, Philip B. Rawlins, J. Willem M. Nissink, Alexander Pflug, Caroline Truman
Publikováno v:
Biochemical Journal
The activation loop (A-loop) plays a key role in regulating the catalytic activity of protein kinases. Phosphorylation in this region enhances the phosphoryl transfer rate of the kinase domain and increases its affinity for ATP. Furthermore, the A-lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8d4c6e582a9e63dc834895d8a9b2dea
https://doi.org/10.1042/bcj20200735
https://doi.org/10.1042/bcj20200735
Autor:
Arne Wilharm, Alexander Pflug, Franz Loos, Oliver Sommerfeld, Gunther O Hofmann, Stefanie Sauer
Publikováno v:
Zeitschrift für Orthopädie und Unfallchirurgie.
Zusammenfassung Hintergrund Trauma ist die häufigste Todesursache bei unter 45-Jährigen und trotzdem gibt es nur wenig Daten zu den genauen Todesursachen Schwerverletzter nach Klinikeinlieferung in Deutschland aus den letzten 10 Jahren. Ziel der Ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e92abc5994cf7f0241c375ffab85e0e
https://doi.org/10.1055/a-1651-0996
https://doi.org/10.1055/a-1651-0996
Autor:
Arne, Wilharm, Alexander, Pflug, Franz, Loos, Oliver, Sommerfeld, Gunther O, Hofmann, Stefanie, Sauer
Publikováno v:
Zeitschrift fur Orthopadie und Unfallchirurgie.
The leading cause of death among people under 45 years of age is trauma. However, there is little information from the last 10 years on the exact causes of death of seriously injured people after hospital admission in Germany. The aim of the study is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::28834c46dffb4bf25a2fcfa0443ca49e
https://pubmed.ncbi.nlm.nih.gov/34963187
https://pubmed.ncbi.nlm.nih.gov/34963187
Autor:
William, McCoull, Scott, Boyd, Martin R, Brown, Muireann, Coen, Olga, Collingwood, Nichola L, Davies, Ann, Doherty, Gary, Fairley, Kristin, Goldberg, Elizabeth, Hardaker, Guang, He, Edward J, Hennessy, Philip, Hopcroft, George, Hodgson, Anne, Jackson, Xiefeng, Jiang, Ankur, Karmokar, Anne-Laure, Lainé, Nicola, Lindsay, Yumeng, Mao, Roshini, Markandu, Lindsay, McMurray, Neville, McLean, Lorraine, Mooney, Helen, Musgrove, J Willem M, Nissink, Alexander, Pflug, Venkatesh Pilla, Reddy, Philip B, Rawlins, Emma, Rivers, Marianne, Schimpl, Graham F, Smith, Sharon, Tentarelli, Jon, Travers, Robert I, Troup, Josephine, Walton, Cheng, Wang, Stephen, Wilkinson, Beth, Williamson, Jon, Winter-Holt, Dejian, Yang, Yuting, Zheng, Qianxiu, Zhu, Paul D, Smith
Publikováno v:
Journal of medicinal chemistry. 64(18)
Inhibition of Mer and Axl kinases has been implicated as a potential way to improve the efficacy of current immuno-oncology therapeutics by restoring the innate immune response in the tumor microenvironment. Highly selective dual Mer/Axl kinase inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5ae60041f0f2dfe86225bfbc9ef0aea3
https://pubmed.ncbi.nlm.nih.gov/34478292
https://pubmed.ncbi.nlm.nih.gov/34478292
Autor:
Ross Overman, Juli Warwicker, Kristin Goldberg, Alexander Pflug, Jeremy S. Disch, Allison Olszewski, Philip B. Rawlins, John P. Guilinger, William McCoull, Rachael Jetson, Anthony D. Keefe, Simon A. Woodcock, Emma Rivers, Olga Collingwood, Elizabeth Hardaker, Sana Bazzaz, Elizabeth Underwood, Marianne Schimpl, J. Willem M. Nissink, Lindsay McMurray, Carolyn Blackett, Diana Gikunju, Jon Winter-Holt, Edward J. Hennessy, Paul D. Smith, Marian Preston, Caroline Truman, Matthew A. Clark, Ying Zhang
Publikováno v:
Journal of medicinal chemistry. 64(6)
Mer is a member of the TAM (Tyro3, Axl, Mer) kinase family that has been associated with cancer progression, metastasis, and drug resistance. Their essential function in immune homeostasis has prompted an interest in their role as modulators of antit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19e50f9caa68d2f39107bd3f4cc78ebb
https://pubmed.ncbi.nlm.nih.gov/33683117
https://pubmed.ncbi.nlm.nih.gov/33683117
Autor:
Stefan Reich, Stephanie Gaudon, Patricia Resa-Infante, Mathilde Lethier, Wiebke Manuela Schulze, Stephen Cusack, Alexander Pflug
Publikováno v:
Nucleic Acids Research
'Nucleic Acids Research ', vol: 46, pages: 956-971 (2018)
'Nucleic Acids Research ', vol: 46, pages: 956-971 (2018)
Influenza polymerase uses short capped primers snatched from nascent Pol II transcripts to initiate transcription of viral mRNAs. Here we describe crystal structures of influenza A and B polymerase bound to a capped primer in a configuration consiste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8007b46822e8aeeef8ff402df6d2a2ff
https://doi.org/10.1093/nar/gkx1210
https://doi.org/10.1093/nar/gkx1210