Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Alexander, Ooms"'
Autor:
Ioana R. Marian, Alexander Ooms, Jane Holmes, Matthew J. Parkes, Alastair D. Lamb, Richard J. Bryant
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-9 (2024)
Abstract Background The TRANSLATE (TRANSrectal biopsy versus Local Anaesthetic Transperineal biopsy Evaluation) trial assesses the clinical and cost-effectiveness of two biopsy procedures in terms of detection of clinically significant prostate cance
Externí odkaz:
https://doaj.org/article/06521101632f458bae35061011c1d43c
Autor:
Miriam Dixon-Zegeye, Rachel Shaw, Linda Collins, Kendra Perez-Smith, Alexander Ooms, Maggie Qiao, Pan Pantziarka, Louise Izatt, Marc Tischkowitz, Rachel E. Harrison, Angela George, Emma R. Woodward, Simon Lord, Lara Hawkes, D. Gareth Evans, James Franklin, Helen Hanson, Sarah P. Blagden
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-14 (2024)
Abstract Background Li-Fraumeni syndrome (LFS) is a rare autosomal dominant disease caused by inherited or de novo germline pathogenic variants in TP53. Individuals with LFS have a 70–100% lifetime risk of developing cancer. The current standard of
Externí odkaz:
https://doaj.org/article/cf49679192c94035afcc32e77d21fae6
Autor:
Caroline E. Plant, Alexander Ooms, Jonathan A. Cook, Matthew L. Costa, on behalf of the DRAFFT2 collaborators
Publikováno v:
Bone & Joint Open, Vol 5, Iss 2, Pp 132-138 (2024)
Aims: The primary aim of this study was to report the radiological outcomes of patients with a dorsally displaced distal radius fracture who were randomized to a moulded cast or surgical fixation with wires following manipulation and closed reduction
Externí odkaz:
https://doaj.org/article/39b3f8c2e6f84c54aac8e1b8752f6108
Autor:
Iain B McInnes, Stefan Siebert, Paul Bowness, Laura C Coates, Anne Francis, Bruce W Kirkham, Alexander Ooms, Hussein Al-Mossawi, Louise Bennett, Nicole Yager, Duncan Richards, Mimi Bogale, Carl Goodyear, Sylvine Lalnunhlimi, Leonie S Taams, Aysin Tulunay Virlan
Publikováno v:
BMJ Open, Vol 13, Iss 9 (2023)
Introduction Psoriatic arthritis (PsA) affects around 150 000 people in the UK of whom around 50% require treatment with biologics. The most used biologics for PsA target tumour necrosis factor (TNF) or interleukin-17A (IL-17A). About 50% of patients
Externí odkaz:
https://doaj.org/article/fec1e3e94bdb470b8bf658b6414ae65c
Autor:
Ben George, James Good, Alexander Ooms, Somnath Mukherjee, Matthew J Parkes, Tim Maughan, Suliana Teoh, Rob Owens, Kwun-Ye Chu, Joe Drabble, Maxwell Robinson, Lynda Swan, Lucinda Griffiths, Killian Nugent
Publikováno v:
BMJ Open, Vol 13, Iss 9 (2023)
Introduction Online adaptive MR-guided radiotherapy allows for dose escalation to pancreatic cancer while sparing surrounding critical organs. We seek to evaluate the safety of delivering hypofractionated five-fraction, three-fraction and single-frac
Externí odkaz:
https://doaj.org/article/90fadb9dc4474dc097d829c84ae0ebd1
Autor:
Benjamin Speich, Ayodele Odutayo, Nicholas Peckham, Alexander Ooms, Jamie R. Stokes, Ramon Saccilotto, Dmitry Gryaznov, Belinda von Niederhäusern, Bethan Copsey, Douglas G. Altman, Matthias Briel, Sally Hopewell
Publikováno v:
Trials, Vol 23, Iss 1, Pp 1-9 (2022)
Abstract Background To assess the quality of reporting of RCT protocols approved by UK research ethics committees before and after the publication of the Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) guideline. Methods W
Externí odkaz:
https://doaj.org/article/8a043167f2c14e0c91b35bc1c75c4066
Autor:
Alexander Ooms, Susan J. Dutton, Scott Parsons, Beth Fordham, Caroline Hing, Sarah Lamb, Toby Smith
Publikováno v:
Trials, Vol 22, Iss 1, Pp 1-9 (2021)
Abstract Background Total hip (THR) and total knee replacements (TKR) are two highly successful orthopaedic procedures that reduce pain for people with osteoarthritis. Previous evidence suggests that physical activity, at best, remains the same pre-
Externí odkaz:
https://doaj.org/article/3e8a6550b2c343399bec8623a3da3742
Autor:
Wilby Williamson, Adam James Lewandowski, Odaro John Huckstep, Winok Lapidaire, Alexander Ooms, Cheryl Tan, Afifah Mohamed, Maryam Alsharqi, Mariane Bertagnolli, William Woodward, Cameron Dockerill, Annabelle McCourt, Yvonne Kenworthy, Holger Burchert, Aiden Doherty, Julia Newton, Henner Hanssen, John Kennedy Cruickshank, Richard McManus, Jane Holmes, Chen Ji, Sharon Love, Elena Frangou, Colin Everett, Melvyn Hillsdon, Helen Dawes, Charlie Foster, Paul Leeson
Publikováno v:
EClinicalMedicine, Vol 48, Iss , Pp 101445- (2022)
Summary: Background: Exercise is advised for young adults with elevated blood pressure, but no trials have investigated efficacy at this age. We aimed to determine whether aerobic exercise, self-monitoring and motivational coaching lowers blood press
Externí odkaz:
https://doaj.org/article/6d71a7cdabcb4569a4825d7576d50a0a
Autor:
Michael Dunn, Beth Fordham, Karen Barker, Scott Parsons, Susan Dutton, Sarah Lamb, Jamila Kassam, Toby O Smith, Iain McNamara, Alexander Ooms, Caroline Hing, Steve Algar, Zara Hansen, Sonny Driver, Peter Penny, Celia Woodhouse, Tracey Potter, Helena Daniell, Alex Herring, Yan Cunningham, Irrum Afzal, Maninderpal Matharu, Tamsin Hughes, Erin Hannink, Michelle Moynihan, Angela Garrett, Ian Smith, Vicki Barber, Malcolm Hart, MayEe Png, Dawn Lockey
Publikováno v:
BMJ Open, Vol 12, Iss 5 (2022)
Objective To test the effectiveness of a behaviour change physiotherapy intervention to increase physical activity compared with usual rehabilitation after total hip replacement (THR) or total knee replacement (TKR).Design Multicentre, pragmatic, two
Externí odkaz:
https://doaj.org/article/39db9e15694c4feebd734390e29c0a77
Autor:
Matthew L Costa, Juul Achten, Alexander Ooms, May Ee Png, Jonathan Cook, Melina Dritsaki, Sarah E Lamb, Robin Lerner, Kylea Draper, Marta Campolier, Helen Dakin, Alwin McGibbon, Nicholas Parsons, Helen Hedley, Joseph Dias, the DRAFFT 2 Collaborators
Publikováno v:
Health Technology Assessment, Vol 26, Iss 11 (2022)
Background: Patients with a displaced fracture of the distal radius are frequently offered surgical fixation. Manipulation of the fracture and moulded plaster casting is an alternative treatment that avoids metal implants, but evidence of its effecti
Externí odkaz:
https://doaj.org/article/297ce31c56d1415eadd5b09c2502e989