Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Alexander, Kolbanovskiy"'
Autor:
Olga Rechkoblit, Alexander Kolbanovskiy, Hannah Landes, Nicholas E. Geacintov, Aneel K. Aggarwal
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Benzo[a]pyrene (BP) is a carcinogen in cigarette smoke that upon metabolic activation reacts with guanine. Here, the authors present the structures of the translesion DNA synthesis polymerase Rev1 in complex with three of the four possible stereoisom
Externí odkaz:
https://doaj.org/article/7dfd4600623948c893925d6ff8837886
Autor:
Suse Broyde, Hong Mu, Nicholas E. Geacintov, Yuan Cho Lee, Jung Hyun Min, Katie M. Feher, Yoonjung Shim, Vladimir Shafirovich, Alexander Kolbanovskiy, Alexander Durandin
Publikováno v:
DNA Repair (Amst)
The Nucleotide Excision Repair (NER) mechanism removes a wide spectrum of structurally different lesions that critically depend on the binding of the DNA damage sensing NER factor XPC-RAD23B (XPC) to the lesions. The bulky mutagenic benzo[a]pyrene di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c418f3d027699d75c8135dd89415bb7
https://europepmc.org/articles/PMC8423485/
https://europepmc.org/articles/PMC8423485/
Autor:
Olga I. Lavrik, Nadejda I. Rechkunova, Alexander Kolbanovskiy, Nicholas E. Geacintov, N. A. Lebedeva, Lidia V. Starostenko
Publikováno v:
DNA Repair. 24:1-9
The combined action of oxidative stress and genotoxic polycyclic aromatic hydrocarbons derivatives can lead to cluster-type DNA damage that includes both a modified nucleotide and a bulky lesion. As an example, we investigated the possibility of repa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bc2892968a930d86c4d4c822a4e4c86
https://doi.org/10.1016/j.dnarep.2014.10.005
https://doi.org/10.1016/j.dnarep.2014.10.005
Autor:
Lu Zhang, Konstantin Kropachev, Nicholas E. Geacintov, Marina Kolbanovskiy, Shuang Ding, Yuqin Cai, Alexander Kolbanovskiy, Suse Broyde, Shantu Amin, Adam G. Schwaid, Zhi Liu
Publikováno v:
Chemical Research in Toxicology. 26:783-793
The structural origins of differences in susceptibilities of various DNA lesions to nucleotide excision repair (NER) are poorly understood. Here we compared, in the same sequence context, the relative NER dual incision efficiencies elicited by two st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5602541415d92555a7275e1aefe43dcf
https://doi.org/10.1021/tx400080k
https://doi.org/10.1021/tx400080k
Autor:
Antonio S. Minero, Nicholas E. Geacintov, Natalia A. Cherepanova, Olga V. Lukashevich, Elizaveta S. Gromova, Alexander Kolbanovskiy
Publikováno v:
FEBS Journal. 279:3965-3980
The impact of bulky carcinogen-DNA adducts positioned at or near recognition sites (CpG) of eukaryotic DNA methyltransferases on their catalytic activities is poorly understood. In the present study, we employed site-specifically modified 30-mer olig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58e97d0760e9869476acbc053cb02dc2
https://doi.org/10.1111/j.1742-4658.2012.08756.x
https://doi.org/10.1111/j.1742-4658.2012.08756.x
Autor:
Lu Zhang, Nicholas E. Geacintov, Konstantin Kropachev, Marina Kolbanovskiy, Suse Broyde, Lihua Wang, Alexander Kolbanovskiy, Hong Mu
Publikováno v:
Nucleic Acids Research
Nucleotide excision repair (NER) efficiencies of DNA lesions can vary by orders of magnitude, for reasons that remain unclear. An example is the pair of N-(2'-deoxyguanosin-8-yl)-2-aminofluorene (dG-C8-AF) and N-(2'-deoxyguanosin-8-yl)-2-acetylaminof
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dbcab29cd9a443664b6972ec14092c6
https://doi.org/10.1093/nar/gks788
https://doi.org/10.1093/nar/gks788
Autor:
Nicholas E. Geacintov, Konstantin Kropachev, Karam El-Bayoumy, Marina Kolbanovskiy, Shantu Amin, Alexander Kolbanovskiy, Jacek Krzeminski, Byeong Hwa Yun, Dara Reeves
Publikováno v:
Chemical Research in Toxicology. 24:65-72
Ubiquitous environmental agents [e.g., polynuclear aromatic hydrocarbons (PAHs) and their nitrated derivatives (NO(2)-PAHs)] that are known to induce mammary cancer in rodents are regarded as potential human risk factors for inducing analogous human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb5527b6c450c6b7aaedb0e18f130d40
https://doi.org/10.1021/tx100284h
https://doi.org/10.1021/tx100284h
Autor:
Marina Kolbanovskiy, Konstantin Kropachev, Yuqin Cai, Nicholas E. Geacintov, Alexander Kolbanovskiy, Dinshaw J. Patel, Suse Broyde
Publikováno v:
The Chemical Biology of DNA Damage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d55d25251395c76d9d0bbdbcc7adba5
https://doi.org/10.1002/9783527630110.ch12
https://doi.org/10.1002/9783527630110.ch12
Autor:
Lucy Malinina, Suse Broyde, Nicholas E. Geacintov, Alexander Kolbanovskiy, Dinshaw J. Patel, Olga Rechkoblit
Publikováno v:
Nature structural & molecular biology
The aromatic amine carcinogen 2-aminofluorene (AF) forms covalent adducts with DNA, predominantly with guanine at the C8 position. Such lesions are bypassed by Y-family polymerases such as Dpo4 via error-free and error-prone mechanisms. We show that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d872286a93a9e4b3f9ea4527f36ba2b6
https://doi.org/10.1038/nsmb.1771
https://doi.org/10.1038/nsmb.1771
Autor:
R. Stephen Lloyd, Carmelo J. Rizzo, Alexander Kolbanovskiy, Richard D. Wood, Kinrin Yamanaka, Irina G. Minko, Ivan D. Kozekov, Kei Ichi Takata
Publikováno v:
Chemical Research in Toxicology
DNA polymerase nu (POLN or pol nu) is a newly discovered A family polymerase that generates a high error rate when incorporating nucleotides opposite dG; its translesion DNA synthesis (TLS) capability has only been demonstrated for high fidelity repl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e1bb5d776b3fe72dfbf08005f9dfbc1
https://doi.org/10.1021/tx900449u
https://doi.org/10.1021/tx900449u