Zobrazeno 1 - 10
of 348
pro vyhledávání: '"Alexander, Knuth"'
Autor:
Shunzhou Wan, Deepak Kumar, Valentin Ilyin, Ussama Al Homsi, Gulab Sher, Alexander Knuth, Peter V. Coveney
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract The advent of personalised medicine promises a deeper understanding of mechanisms and therefore therapies. However, the connection between genomic sequences and clinical treatments is often unclear. We studied 50 breast cancer patients belon
Externí odkaz:
https://doaj.org/article/2a363102d41c4c2d90161fca91a7f1ec
Autor:
Mona O. Mohsen, Matthew D. Heath, Gustavo Cabral-Miranda, Cyrill Lipp, Andris Zeltins, Marcos Sande, Jens V. Stein, Carsten Riether, Elisa Roesti, Lisha Zha, Paul Engeroff, Aadil El-Turabi, Thomas M. Kundig, Monique Vogel, Murray A. Skinner, Daniel E. Speiser, Alexander Knuth, Matthias F. Kramer, Martin F. Bachmann
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-12 (2019)
Abstract Background Induction of strong T cell responses, in particular cytotoxic T cells, is a key for the generation of efficacious therapeutic cancer vaccines which yet, remains a major challenge for the vaccine developing world. Here we demonstra
Externí odkaz:
https://doaj.org/article/990f850b12da41e5993abd4c2dba075c
Autor:
Alexander R. Siebenhüner, Heike Seifert, Helga Bachmann, Burkhardt Seifert, Thomas Winder, Jonas Feilchenfeldt, Stefan Breitenstein, Pierre-Alain Clavien, Roger Stupp, Alexander Knuth, Bernhard Pestalozzi, Panagiotis Samaras
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-10 (2018)
Abstract Background Biliary tract cancer (BTC) is a dismal disease, even after curative intent surgery. We conducted this prospective, non-randomized phase II study to evaluate the feasibility and efficacy of cisplatin and gemcitabine as adjuvant tre
Externí odkaz:
https://doaj.org/article/5d29d9c60cc24dc8be376eb4754c2f55
Autor:
Mona O. Mohsen, Monique Vogel, Carsten Riether, Julius Muller, Silvia Salatino, Nicola Ternette, Ariane C. Gomes, Gustavo Cabral-Miranda, Aadil El-Turabi, Christiane Ruedl, Thomas M. Kundig, Said Dermime, Alexander Knuth, Daniel E. Speiser, Martin F. Bachmann
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Personalized cancer vaccines hold promises for future cancer therapy. Targeting neoantigens is perceived as more beneficial compared to germline, non-mutated antigens. However, it is a practical challenge to identify and vaccinate patients with neoan
Externí odkaz:
https://doaj.org/article/6c2903ce3562494484cb721b3119696e
Autor:
Maries van den Broek, Alexander Knuth, Burkhard Becher, Hideo Yagita, Karina Silina, Karim Milo, Michal Beffinger, Oscar Camilo Salgado, Ali Bransi
Prevention of tolerance by anti-CD40 + IL-2cx + IL-12Fc.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fbac3a9f602c63af70f41367c1bc3aa
https://doi.org/10.1158/2326-6066.22537211
https://doi.org/10.1158/2326-6066.22537211
Autor:
Maries van den Broek, Alexander Knuth, Burkhard Becher, Hideo Yagita, Karina Silina, Karim Milo, Michal Beffinger, Oscar Camilo Salgado, Ali Bransi
Impact of various immune interventions on preventing tolerance and improving TCR-I cells proliferation and function.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c526188c9581d93b8dafce1508fa0360
https://doi.org/10.1158/2326-6066.22537196.v1
https://doi.org/10.1158/2326-6066.22537196.v1
Autor:
Maries van den Broek, Alexander Knuth, Burkhard Becher, Hideo Yagita, Karina Silina, Karim Milo, Michal Beffinger, Oscar Camilo Salgado, Ali Bransi
Legends for supplementary figures S1-S7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bd2730d06bdc94d23bae9d47a049cbc
https://doi.org/10.1158/2326-6066.22537220.v1
https://doi.org/10.1158/2326-6066.22537220.v1
Data from Short Peptide Vaccine Induces CD4+ T Helper Cells in Patients with Different Solid Cancers
Autor:
Eckhart Kaempgen, Thomas Woelfel, Ulf Forssmann, Ulrike Gnad-Vogt, Adrian Ochsenbein, Alexander Knuth, Lotta von Boehmer, Dagmar Hess, Steffen Böhm, Nicolas Mach, Elisa Gallerani, Volker Lennerz, Stefanie Gross
Previous cancer vaccination trials often aimed to activate CD8+ cytotoxic T-cell (CTL) responses with short (8–10mer) peptides and targeted CD4+ helper T cells (TH) with HLA class II–binding longer peptides (12–16 mer) that were derived from tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b85d5214a96713f377fd7c838d05539a
https://doi.org/10.1158/2326-6066.c.6548519.v1
https://doi.org/10.1158/2326-6066.c.6548519.v1
Autor:
Eckhart Kaempgen, Thomas Woelfel, Ulf Forssmann, Ulrike Gnad-Vogt, Adrian Ochsenbein, Alexander Knuth, Lotta von Boehmer, Dagmar Hess, Steffen Böhm, Nicolas Mach, Elisa Gallerani, Volker Lennerz, Stefanie Gross
Short peptide vaccine induces CD4+ T helper cells in patients with different solid cancers - desription of methods according to MIATA guidelines(MIATA checklist)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c553b9773f0809256a7d90dea6886ef
https://doi.org/10.1158/2326-6066.22537676
https://doi.org/10.1158/2326-6066.22537676
Autor:
Eckhart Kaempgen, Thomas Woelfel, Ulf Forssmann, Ulrike Gnad-Vogt, Adrian Ochsenbein, Alexander Knuth, Lotta von Boehmer, Dagmar Hess, Steffen Böhm, Nicolas Mach, Elisa Gallerani, Volker Lennerz, Stefanie Gross
(1) Gating strategy, (2) representative examples of the time course of spCD4 responses, (3) individual cytokine profile and magnitude of spCD4 responses of all patients with detected spCD4 T cell response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8baf70b081d605d9b36778c33745704a
https://doi.org/10.1158/2326-6066.22537679
https://doi.org/10.1158/2326-6066.22537679