Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Alexander, Knaupp"'
Autor:
Steffen Lippold, Karishma Mistry, Sunidhi Lenka, Kevin Whang, Peilu Liu, Sebastian Pitschi, Felix Kuhne, Dietmar Reusch, Lance Cadang, Alexander Knaupp, Saeed Izadi, Alexis Dunkle, Feng Yang, Tilman Schlothauer
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Human Fc gamma receptor IIa (FcγRIIa) or CD32a has two major allotypes with a single amino acid difference at position 131 (histidine or arginine). Differences in FcγRIIa allotypes are known to impact immunological responses such as the clinical ou
Externí odkaz:
https://doaj.org/article/69a3b2655a744a0981d1ba12450c4881
Autor:
Christoph Gstöttner, Alexander Knaupp, Gestur Vidarsson, Dietmar Reusch, Tilman Schlothauer, Manfred Wuhrer, Elena Domínguez-Vega
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The impact of antibody glycoforms on FcγRIIa activation and immune responses is poorly understood. Yet, glycoform binding assessment remains one of the major analytical challenges requiring long enrichment or glycoengineering steps. Here, we develop
Externí odkaz:
https://doaj.org/article/9fdd4b98cb2049af8d3785c42cceb466
Autor:
Michael J. E. Marshall, Alexander Knaupp, Christian Spick, Ilker Koese, Maria Maier, Mark S. Cragg, Florian Cymer, Tilman Schlothauer
Publikováno v:
The Journal of Immunology. 210:1837-1848
The classical complement system represents a central effector mechanism of Abs initiated by the binding of C1q to target bound IgG. Human C1q contains six heterotrimeric globular head groups that mediate IgG interaction, resulting in an avidity-drive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1574a9059fe0899ece0e0eeac38b47c5
https://doi.org/10.4049/jimmunol.2100370
https://doi.org/10.4049/jimmunol.2100370
Autor:
Steffen Lippold, Alexander Knaupp, Arnoud H. de Ru, Rayman T. N. Tjokrodirijo, Peter A. van Veelen, Erwin van Puijenbroek, Steven W. de Taeye, Dietmar Reusch, Gestur Vidarsson, Manfred Wuhrer, Tilman Schlothauer, David Falck
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
The crystallizable fragment (Fc) of immunoglobulin G (IgG) activates key immunological responses by interacting with Fc gamma receptors (FcɣR). FcɣRIIIb contributes to neutrophil activation and is involved in antibody-dependent cellular cytotoxicit
Externí odkaz:
https://doaj.org/article/304e5e39a8ea4ca9a3464086e8534f7a
Autor:
Steffen Lippold, Michaela Hook, Christian Spick, Alexander Knaupp, Kevin Whang, Fabian Ruperti, Lance Cadang, Nisana Andersen, Annette Vogt, Michael Grote, Dietmar Reusch, Markus Haberger, Feng Yang, Tilman Schlothauer
Publikováno v:
Analytical Chemistry. 95:2260-2268
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca4f53e3f3a5ec666eb586b8553e20c3
https://doi.org/10.1021/acs.analchem.2c03827
https://doi.org/10.1021/acs.analchem.2c03827
Autor:
Thomas E. Kraft, Wolfgang F. Richter, Thomas Emrich, Alexander Knaupp, Michaela Schuster, Andreas Wolfert, Hubert Kettenberger
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
The pharmacokinetic (PK) properties of therapeutic antibodies directly affect efficacy, dose and dose intervals, application route and tissue penetration. In indications where health-care providers and patients can choose between several efficacious
Externí odkaz:
https://doaj.org/article/fa4ed80fa74740e48dfa85c307a36245
Autor:
Alexander Knaupp, Christoph Gstöttner, Manfred Wuhrer, Dietmar Reusch, Elena Domínguez-Vega, Tony Christopeit, Michaela Hook, Markus Haberger, Tilman Schlothauer
Publikováno v:
Analytical Chemistry
Analytical Chemistry, 93(45), 15133-15141. AMER CHEMICAL SOC
Analytical Chemistry, 93(45), 15133-15141. AMER CHEMICAL SOC
Monoclonal antibody (mAb) pharmaceuticals consist of a plethora of different proteoforms with different functional characteristics, including pharmacokinetics and pharmacodynamics, requiring their individual assessment. Current binding techniques do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cebbff5f0106af654b0a04c742dc105
https://zenodo.org/record/6777244
https://zenodo.org/record/6777244
Autor:
Tetyana Dashivets, Marco Thomann, Petra Rueger, Alexander Knaupp, Johannes Buchner, Tilman Schlothauer
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0143520 (2015)
Therapeutic performance of recombinant antibodies relies on two independent mechanisms: antigen recognition and Fc-mediated antibody effector functions. Interaction of Fc-fragment with different FcR triggers antibody-dependent cellular cytotoxicity a
Externí odkaz:
https://doaj.org/article/3fed091754384dec8a0d04e6fc49c565
Autor:
Thomas Bouvarel, Bastiaan L. Duivelshof, Julien Camperi, Tilman Schlothauer, Alexander Knaupp, Cinzia Stella, Davy Guillarme
Publikováno v:
Journal of Chromatography A. 1682:463518
Affinity liquid chromatography using FcRn and FcγRIIIa columns can provide important information on the drug effector functions and the unique PK/PD properties of therapeutic mAbs. In this study, we propose a unique strategy to improve the performan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb5db43c8841b2b00e66bc124a03a3c2
https://doi.org/10.1016/j.chroma.2022.463518
https://doi.org/10.1016/j.chroma.2022.463518
Autor:
Hubert Kettenberger, Michael B. Otteneder, Alexander Knaupp, Martin R. Edelmann, Tilman Schlothauer
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 62:751-757
The number of therapeutic antibodies in research and development as well as their complexity increases from year to year. Novel therapeutic protein formats, such as Fc-fusions, bispecific, or multivalent antibodies, are currently in preclinical and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d95168b3e4cb5ea4abd4915dafd836e9
https://doi.org/10.1002/jlcr.3793
https://doi.org/10.1002/jlcr.3793