Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Alexander, Klimke"'
Autor:
Alexander, Klimke, Steffen, Güttler, Petric, Kuballa, Simone, Janzen, Sonja, Ortmann, Adriano, Flora
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1953
The use of CRISPR/Cas9 to modify the mouse genome has gained immense interest in the past few years since it allows the direct modification of embryos, bypassing the need of labor-intensive procedures for the manipulation of embryonic stem cells. By
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cf5c751c4e7d00a1bb95cd9341bbc003
https://pubmed.ncbi.nlm.nih.gov/30912024
https://pubmed.ncbi.nlm.nih.gov/30912024
Autor:
Adriano Flora, Steffen Güttler, Simone Janzen, Sonja Ortmann, Alexander Klimke, Petric Kuballa
Publikováno v:
Target Identification and Validation in Drug Discovery ISBN: 9781493991440
The use of CRISPR/Cas9 to modify the mouse genome has gained immense interest in the past few years since it allows the direct modification of embryos, bypassing the need of labor-intensive procedures for the manipulation of embryonic stem cells. By
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4907abefb4e727ad412bd61b3eca9d62
https://doi.org/10.1007/978-1-4939-9145-7_13
https://doi.org/10.1007/978-1-4939-9145-7_13
Autor:
Joon Sub Lee, Rui Song, Polina V. Lishko, Lin He, Richard M. Harland, Muriel Lizé, Ying Wan, Michael Kessel, Alexander Klimke, Peter Walentek, Nicole Sponer, Gary Dixon
Publikováno v:
Nature, vol 510, iss 7503
Nature
Nature
The mir-34/449 family consists of six homologous miRNAs at three genomic loci. Redundancy of miR-34/449 miRNAs and their dominant expression in multiciliated epithelia suggest a functional significance in ciliogenesis. Here we report that mice defici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ed06b8e8f28e86ed1ab515a16931205
https://doi.org/10.1038/nature13413
https://doi.org/10.1038/nature13413
Publikováno v:
Journal of Molecular Medicine
Primordial germ cells (PGCs) are induced in the epiblast early in mammalian development. They develop their specific fate separate from somatic cells by the generation of a unique transcriptional profile and by epigenetic modifications of histones an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2f961881da839a64c65f483ec2e677a
https://pubmed.ncbi.nlm.nih.gov/22584374
https://pubmed.ncbi.nlm.nih.gov/22584374
Publikováno v:
C27. GENETIC PROGRAMS DRIVING LUNG DEVELOPMENT AND REGENERATION.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee1d8983839a849d714fe8ea6c667f40
https://doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a4218
https://doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a4218
Publikováno v:
European Journal of Cancer. 50:S84
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7922b5893be27970b696dc812489a0bb
https://doi.org/10.1016/s0959-8049(14)50314-0
https://doi.org/10.1016/s0959-8049(14)50314-0
Publikováno v:
Europe PubMed Central
Cell Cycle
Cell Cycle
MicroRNAs of the miR-34/449 family mediate cell cycle arrest and tumor suppression. Here we show that the expression of microRNA miR-449a, unlike its paralogue miR-34a, is highly tissue specific and largely restricted to pulmonary and testicular tiss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc86717bf81bfaf18c699394385bb1f9
http://europepmc.org/abstract/med/21088493
http://europepmc.org/abstract/med/21088493
Publikováno v:
Europe PubMed Central
Cell Cycle
Cell Cycle
The microRNAs 449a, b, and c (miR-449) are potent inducers of cell death, cell cycle arrest, and/or cell differentiation. They belong to the same family as the p53-responsive microRNAs miR-34. Instead of p53, however, the cell cycle regulatory transc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c968cab4215f5f762c651d1877801121
http://europepmc.org/abstract/med/21857159
http://europepmc.org/abstract/med/21857159