Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Alexander, Kel"'
Autor:
Parvathi A. Myer, Hyunjin Kim, Anna M. Blümel, Ellen Finnegan, Alexander Kel, Taylor V. Thompson, John M. Greally, Jochen HM. Prehn, Darran P. O’Connor, Richard A. Friedman, Aris Floratos, Sudipto Das
Publikováno v:
Gastro Hep Advances, Vol 1, Iss 3, Pp 328-341 (2022)
Background and Aims: Individuals of African (AFR) ancestry have a higher incidence of colorectal cancer (CRC) than those of European (EUR) ancestry and exhibit significant health disparities. Previous studies have noted differences in the tumor micro
Externí odkaz:
https://doaj.org/article/18a7ea9fffb34eac8439f8f87e7ef340
Autor:
Pierre Sabatier, Christian M. Beusch, Amir A. Saei, Mike Aoun, Noah Moruzzi, Ana Coelho, Niels Leijten, Magnus Nordenskjöld, Patrick Micke, Diana Maltseva, Alexander G. Tonevitsky, Vincent Millischer, J. Carlos Villaescusa, Sandeep Kadekar, Massimiliano Gaetani, Kamilya Altynbekova, Alexander Kel, Per-Olof Berggren, Oscar Simonson, Karl-Henrik Grinnemo, Rikard Holmdahl, Sergey Rodin, Roman A. Zubarev
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
To characterize molecular changes during cell type transitions, the authors develop a method to simultaneously measure protein expression and thermal stability changes. They apply this approach to study differences between human pluripotent stem cell
Externí odkaz:
https://doaj.org/article/ea00b3040ab748c68e25909b2a8c2546
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Only 2% of glioblastoma multiforme (GBM) patients respond to standard therapy and survive beyond 36 months (long-term survivors, LTS), while the majority survive less than 12 months (short-term survivors, STS). To understand the mechanism leading to
Externí odkaz:
https://doaj.org/article/e15590b99d0c4ea5a178a487e7a161cd
Walking pathways with positive feedback loops reveal DNA methylation biomarkers of colorectal cancer
Autor:
Alexander Kel, Ulyana Boyarskikh, Philip Stegmaier, Leonid S. Leskov, Andrey V. Sokolov, Ivan Yevshin, Nikita Mandrik, Daria Stelmashenko, Jeannette Koschmann, Olga Kel-Margoulis, Mathias Krull, Anna Martínez-Cardús, Sebastian Moran, Manel Esteller, Fedor Kolpakov, Maxim Filipenko, Edgar Wingender
Publikováno v:
BMC Bioinformatics, Vol 20, Iss S4, Pp 1-20 (2019)
Abstract Background The search for molecular biomarkers of early-onset colorectal cancer (CRC) is an important but still quite challenging and unsolved task. Detection of CpG methylation in human DNA obtained from blood or stool has been proposed as
Externí odkaz:
https://doaj.org/article/11d6eb61a8ec45feae5907e1d26ca226
Autor:
Katie Lloyd, Stamatia Papoutsopoulou, Emily Smith, Philip Stegmaier, Francois Bergey, Lorna Morris, Madeleine Kittner, Hazel England, Dave Spiller, Mike H. R. White, Carrie A. Duckworth, Barry J. Campbell, Vladimir Poroikov, Vitor A. P. Martins dos Santos, Alexander Kel, Werner Muller, D. Mark Pritchard, Chris Probert, Michael D. Burkitt, The SysmedIBD Consortium
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 11 (2020)
Inflammatory bowel diseases (IBDs) cause significant morbidity and mortality. Aberrant NF-κB signalling is strongly associated with these conditions, and several established drugs influence the NF-κB signalling network to exert their effect. This s
Externí odkaz:
https://doaj.org/article/98e510497b174f5483defce389417b32
Publikováno v:
Applied Sciences, Vol 12, Iss 5, p 2506 (2022)
NTRK gene fusions are drivers of tumorigenesis events that specific Trk-inhibitors can target. Current knowledge of the downstream pathways activated has been previously limited to the pathways of regulator proteins phosphorylated directly by Trk rec
Externí odkaz:
https://doaj.org/article/a5cc03f3768b4238b1441f2ea36392ad
Autor:
Ayoub Lasri, Viktorija Juric, Maité Verreault, Franck Bielle, Ahmed Idbaih, Alexander Kel, Brona Murphy, Marc Sturrock
Publikováno v:
Royal Society Open Science, Vol 7, Iss 7 (2020)
Glioblastoma (GBM) is the most aggressive malignant primary brain tumour with a median overall survival of 15 months. To treat GBM, patients currently undergo a surgical resection followed by exposure to radiotherapy and concurrent and adjuvant temoz
Externí odkaz:
https://doaj.org/article/06fd69cca52f405e9dcad1eeb3df79c9
Autor:
Ulyana Boyarskikh, Sergey Pintus, Nikita Mandrik, Daria Stelmashenko, Ilya Kiselev, Ivan Evshin, Ruslan Sharipov, Philip Stegmaier, Fedor Kolpakov, Maxim Filipenko, Alexander Kel
Publikováno v:
BMC Medical Genomics, Vol 11, Iss S1, Pp 43-59 (2018)
Abstract Background Small molecule Nutlin-3 reactivates p53 in cancer cells by interacting with the complex between p53 and its repressor Mdm-2 and causing an increase in cancer cell apoptosis. Therefore, Nutlin-3 has potent anticancer properties. Cl
Externí odkaz:
https://doaj.org/article/602c739255df4d17ba710c116d85c82c
Autor:
Archita Biswas, Manuela Salvucci, Kate Connor, Heiko Düssmann, Steven Carberry, Michael Fichtner, Ellen King, Brona Murphy, A.C O’Farrell, Jane Cryan, Alan Beausang, Josephine Heffernan, Mattia Cremona, Bryan T. Hennessy, James Clerkin, Kieron J. Sweeney, Steve MacNally, F Brett, P O’Halloran, Orna Bacon, Simon Furney, Maite Verreault, Emie Quissac, Franck Bielle, Mohammed H Ahmed, Ahmed Idbaih, Sieger Leenstra, Ioannis Ntafoulis, Federica Fabro, Martine Lamfers, Anna Golebiewska, Frank Hertel, Simone P Niclou, Romain Tching Chi Yen, Andreas Kremer, Gonca Dilcan, Francesca Lodi, Ingrid Arijs, Diether Lambrechts, Manasa Kalya P, Alexander Kel, Annette T Byrne, Jochen H.M Prehn
Publikováno v:
Journal of Neuro-Oncology.
Background Glioblastoma (GBM) is an aggressive brain cancer that typically results in death in the first 15 months after diagnosis. There have been limited advances in finding new treatments for GBM. In this study, we investigated molecular differenc
Autor:
Roderick A.F. MacLeod, Hans G. Drexler, Corinna Meyer, Maren Kaufmann, Gregory E. Crawford, Klaus Hornischer, Alexander Kel, Michaela Scherr, Stefan Nagel
Supplementary Table 3 from Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-Cell Acute Lymphoblastic Leukemia by Remote 3′-BCL11B Enhancers and Coregulation by PU.1 and HMGA1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8802466ced7351a4b466ecc5d93fa3d5
https://doi.org/10.1158/0008-5472.22367109.v1
https://doi.org/10.1158/0008-5472.22367109.v1