Zobrazeno 1 - 10
of 524
pro vyhledávání: '"Alexander, Hoffmann"'
Autor:
Stefanie Luecke, Xiaolu Guo, Katherine M Sheu, Apeksha Singh, Sarina C Lowe, Minhao Han, Jessica Diaz, Francisco Lopes, Roy Wollman, Alexander Hoffmann
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 8, Pp 898-932 (2024)
Abstract Macrophages sense pathogens and orchestrate specific immune responses. Stimulus specificity is thought to be achieved through combinatorial and dynamical coding by signaling pathways. While NFκB dynamics are known to encode stimulus informa
Externí odkaz:
https://doaj.org/article/9506b4bcfb2c4ad79bdb71e36b4b87f4
Autor:
Rajesh Parmar, Harry Pickering, Richard Ahn, Maura Rossetti, David W. Gjertson, Felicia Ruffin, Liana C. Chan, Vance G. Fowler, Michael R. Yeaman, Elaine F. Reed, MRSA Systems Immunology Group, Arnold S. Bayer, Yu-Ling Chang, Scott G. Filler, Vance G. Fowler Jr., David Gjertson, Alexander Hoffmann, Felix Mba Medie, Tsuyoshi Mikkaichi, Simon Mitchell, Yan Qin, Batu K. Sharma-Kuinkel, Katherine Sheu, Joshua Thaden, Alan J. Waring, Yan Q. Xiong, Ying Zheng, Michael R. Yeaman.
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionStaphylococcus aureus bacteremia (SAB) is a life-threatening infection particularly involving methicillin-resistant S. aureus (MRSA). In contrast to resolving MRSA bacteremia (RB), persistent MRSA bacteremia (PB) blood cultures remain pos
Externí odkaz:
https://doaj.org/article/a79666f3f3d748269414ccca0d43d820
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109486- (2024)
Summary: Nuclear factor kappa B (NF-κB) is a key regulator in immune signaling and is known to exhibit a digital activation pattern. Yet the molecular basis underlying the heterogeneity in NF-κB activation at single-cell level is not entirely under
Externí odkaz:
https://doaj.org/article/f4788d32d9334588a647fbd05626f697
Autor:
Shah Md Toufiqur Rahman, Apeksha Singh, Sarina Lowe, Mohammad Aqdas, Kevin Jiang, Haripriya Vaidehi Narayanan, Alexander Hoffmann, Myong-Hee Sung
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113940- (2024)
Summary: Individual cell sensing of external cues has evolved through the temporal patterns in signaling. Since nuclear factor κB (NF-κB) signaling dynamics have been examined using a single subunit, RelA, it remains unclear whether more informatio
Externí odkaz:
https://doaj.org/article/41f59cfca5b54e4e9e9ffbfce1ae1c1f
Autor:
Tim Langletz, Philipp M. Grande, Jörn Viell, Daniel Wolters, Josia Tonn, Holger Klose, Sascha G. Schriever, Alexander Hoffmann, Andreas Jupke, Thomas Gries, Sonja Herres-Pawlis
Publikováno v:
Advanced Energy & Sustainability Research, Vol 5, Iss 2, Pp n/a-n/a (2024)
In the modern world, plastics have become indispensable. Due to their properties, they are used for a wide variety of applications ranging from packaging materials to textiles and medical technology. The vast majority of these plastics are made from
Externí odkaz:
https://doaj.org/article/9f125c4543a44c26b01b8e9b89e25a35
Autor:
Catera L Wilder, Diane Lefaudeux, Raisa Mathenge, Kensei Kishimoto, Alma Zuniga Munoz, Minh A Nguyen, Aaron S Meyer, Quen J Cheng, Alexander Hoffmann
Publikováno v:
Molecular Systems Biology, Vol 19, Iss 5, Pp 1-19 (2023)
Abstract Type I interferons (IFN) induce powerful antiviral and innate immune responses via the transcription factor, IFN‐stimulated gene factor (ISGF3). However, in some pathological contexts, type I IFNs are responsible for exacerbating inflammat
Externí odkaz:
https://doaj.org/article/a5383c65692343a1ac5b165b07e6e06b
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The UCLA Ribonomics group reports that the nuclear export efficiency of innate immune mRNAs varies over a hundred-fold range such that for many genes only a small fraction of the newly synthesized premRNA reaches the cytoplasm. They show that nuclear
Externí odkaz:
https://doaj.org/article/6f438cda1c66491d95e50952883601fc
Autor:
Jan C. Brammer, Gerd Blanke, Claudia Kellner, Alexander Hoffmann, Sonja Herres-Pawlis, Ulrich Schatzschneider
Publikováno v:
Journal of Cheminformatics, Vol 14, Iss 1, Pp 1-11 (2022)
Abstract TUCAN is a canonical serialization format that is independent of domain-specific concepts of structure and bonding. The atomic number is the only chemical feature that is used to derive the TUCAN format. Other than that, the format is solely
Externí odkaz:
https://doaj.org/article/00cf3b2a57204320b5d5acc66cd6b40d
Autor:
Philipp Grubwieser, Richard Hilbe, Clemens Michael Gehrer, Manuel Grander, Natascha Brigo, Alexander Hoffmann, Markus Seifert, Sylvia Berger, Igor Theurl, Manfred Nairz, Günter Weiss
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
BackgroundKlebsiella pneumoniae (KP) is a major cause of hospital-acquired infections, such as pneumonia. Moreover, it is classified as a pathogen of concern due to sprawling anti-microbial resistance. During infection, the gram-negative pathogen is
Externí odkaz:
https://doaj.org/article/80faed13abd34ef386fe5da2c3e4468c
Autor:
Raphael Spittler, Niclas Witte, Boris Alexander Hoffmann, Alexandra Marx, Hanke Mollnau, Blanca Quesada-Ocete, Torsten Konrad, Thomas Rostock
Publikováno v:
International Journal of Cardiology: Heart & Vasculature, Vol 47, Iss , Pp 101222- (2023)
Background: The automated NavX Ensite Precision latency-map (LM) algorithm aims to identify atrial tachycardia (AT) mechanisms. However, data on a direct comparison of this algorithm with conventional mapping are scarce. Methods: Patients scheduled f
Externí odkaz:
https://doaj.org/article/b2d021cf86834f81acdacf782a58d5d5