Zobrazeno 1 - 10
of 191
pro vyhledávání: '"Alexander, Gray"'
Publikováno v:
Forensic Science International: Reports, Vol 9, Iss , Pp 100350- (2024)
In this study, we compare the performance of a simple PVP extraction method with a commercially available and widely used kit for recovering DNA from adhesive tapes. This novel method shows almost 60% higher DNA recovery from blood deposits on SceneS
Externí odkaz:
https://doaj.org/article/ec19bf9eedf449f589a6fe54ca6e209c
Publikováno v:
Forensic Science International: Synergy, Vol 8, Iss , Pp 100453- (2024)
Choosing an inappropriate method of sample collection can often have a detrimental impact on DNA recovery. Multiple studies highlight the importance of selecting the recovery method based on the type of surface the DNA sample is located on. This stud
Externí odkaz:
https://doaj.org/article/378bcd171cae4390bba5a32c0a395733
Publikováno v:
Forensic Science International: Synergy, Vol 6, Iss , Pp 100330- (2023)
A review of the literature on DNA transfer and persistence highlights many difficulties that are encountered when conducting research of this nature. One of the main problems highlighted repeatedly in the literature is the prevalence of inherent unco
Externí odkaz:
https://doaj.org/article/7537e8e538ea4290830dc5d9ed01e974
Publikováno v:
Emerging Infectious Diseases, Vol 25, Iss 12, Pp 2257-2260 (2019)
Babesia venatorum is an increasingly prominent zoonotic parasite that predominantly infects wild deer. Our molecular examination of Babesia infecting mammals in the United Kingdom identified 18S sequences in domestic sheep isolates identical to zoono
Externí odkaz:
https://doaj.org/article/30df313c3c8b46278bec2544bfba9084
Publikováno v:
Forensic Science International: Synergy, Vol 3, Iss , Pp 100165- (2021)
Understanding the transfer and persistence of different types of trace evidence between different donor and receiving surfaces under specific conditions, circumstances and alleged competing defence and prosecution hypotheses is a significant need. Ac
Externí odkaz:
https://doaj.org/article/f861ffa56d2449de9bd2f2be349c2de7
Autor:
Alexander Gray, Paul Capewell, Ruth Zadoks, Mark A. Taggart, Andrew S. French, Frank Katzer, Brian R. Shiels, William Weir
Publikováno v:
Current Research in Parasitology and Vector-Borne Diseases, Vol 1, Iss , Pp 100019- (2021)
Redwater fever is an economically important disease of cattle in the United Kingdom caused by the protozoan parasite Babesia divergens. Control efforts are dependent on accurate local historic knowledge of disease occurrence, together with an accurat
Externí odkaz:
https://doaj.org/article/e105763f74c6432ca06a476e96f39fe1
Autor:
Simon Chowdhury, Paul Mainwaring, Liangcai Zhang, Suneel Mundle, Eneida Pollozi, Alexander Gray, Mark Wildgust
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Background: Using progression-free survival (PFS)2, time from randomization to 2nd disease progression or death, is proposed as a surrogate for overall survival (OS) in oncology clinical trials. We used published data from solid tumor trials to asses
Externí odkaz:
https://doaj.org/article/1239882d59684e8893bcd1c066c55dfb
Autor:
D. Grahame Hardie, A. Mark Evans, Ejaife O. Egbani, Alexander Gray, Madhumita Dandapani, Diana Vara-Ciruelos
Many genotoxic cancer treatments activate AMP-activated protein kinase (AMPK), but the mechanisms of AMPK activation in response to DNA damage, and its downstream consequences, have been unclear. In this study, etoposide activates the α1 but not the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0ac6dbdb1f022cabfc5c5d3274ad6b4
https://doi.org/10.1158/1541-7786.c.6540435.v1
https://doi.org/10.1158/1541-7786.c.6540435.v1
Autor:
D. Grahame Hardie, Graeme J. Gowans, Alexander Gray, Diana Vara Ciruelos, Fiona A. Ross, Sarah Fogarty
The AMP-activated protein kinase (AMPK) is activated by phosphorylation at Thr172, either by the tumor suppressor kinase LKB1 or by an alternate pathway involving the Ca2+/calmodulin-dependent kinase, CAMKK2. Increases in AMP:ATP and ADP:ATP ratios,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b57d6fa029e3ecaeee2012b9207f6e5
https://doi.org/10.1158/1541-7786.c.6539973.v1
https://doi.org/10.1158/1541-7786.c.6539973.v1
Autor:
D. Grahame Hardie, Graeme J. Gowans, Alexander Gray, Diana Vara Ciruelos, Fiona A. Ross, Sarah Fogarty
Cellular stresses that increase AMP:ATP and AMP:ATP ratios activate AMPK in normal cells by promoting its phosphorylation by LKB1. This triggers inhibition of cell growth by phosphorylation of acetyl-CoA carboxylase (ACC), Raptor and other targets, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f7f096a646d6fa9fa5b00f7f6db98c1
https://doi.org/10.1158/1541-7786.22511550
https://doi.org/10.1158/1541-7786.22511550