Mechanism of ribosome shutdown by RsfS in Staphylococcus aureus revealed by integrative structural biology approach

Autor: Iskander Khusainov, Bulat Fatkhullin, Simone Pellegrino, Aydar Bikmullin, Wen-ti Liu, Azat Gabdulkhakov, Amr Al Shebel, Alexander Golubev, Denis Zeyer, Natalie Trachtmann, Georg A. Sprenger, Shamil Validov, Konstantin Usachev, Gulnara Yusupova, Marat Yusupov

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)

Upon transition to stationary phase or upon stress, bacteria limit protein synthesis through small inhibitory proteins that bind the ribosome. Here the authors decipher the interaction mode of the bacterial ribosome silencing factor (RsfS) at atomic

Externí odkaz: https://doaj.org/article/1ad738db839640ba9241f8a79ce45330

Abstract P-25: High-Resolution Cryo-Electron Microscopy Structure of the Staphylococcus Aureus Ribosome Brings to Light New Possible Drug Targets

Autor: Alexander Golubev, Bulat Fatkhullin, Iskander Khusainov, Shamil Validov, Marat Yusupov, Konstantin Usachev

Publikováno v: International Journal of Biomedicine, Vol 11, Iss Suppl_1, Pp 22-23 (2021)

Background: Antibiotic resistance is a growing worldwide problem. One of the major resistant bacterial pathogens is Staphylococcus aureus, which became a burden of healthcare systems around the world. To overcome the issue, more drug discovery studie

Externí odkaz: https://doaj.org/article/f9d073d4a59f48179945523b8ee4f99a

A Study of the Radiation Tolerance of CVD Diamond to 70 MeV Protons, Fast Neutrons and 200 MeV Pions

Autor: Lukas Bäni, Andreas Alexopoulos, Marina Artuso, Felix Bachmair, Marcin Ryszard Bartosik, Helge Christoph Beck, Vincenzo Bellini, Vladimir Belyaev, Benjamin Bentele, Alexandre Bes, Jean-Marie Brom, Gabriele Chiodini, Dominik Chren, Vladimir Cindro, Gilles Claus, Johann Collot, John Cumalat, Sébastien Curtoni, Anne Evelyn Dabrowski, Raffaello D’Alessandro, Denis Dauvergne, Wim De Boer, Christian Dorfer, Marc Dünser, Gerald Eigen, Vladimir Eremin, Jacopo Forneris, Laurent Gallin-Martel, Marie-Laure Gallin-Martel, Kock Kiam Gan, Martin Gastal, Abderrahman Ghimouz, Mathieu Goffe, Joel Goldstein, Alexander Golubev, Andrej Gorišek, Eugene Grigoriev, Jörn Grosse-Knetter, Aidan Grummer, Bojan Hiti, Dmitry Hits, Martin Hoeferkamp, Jérôme Hosselet, Fabian Hügging, Chris Hutson, Jens Janssen, Harris Kagan, Keida Kanxheri, Richard Kass, Mladen Kis, Gregor Kramberger, Sergey Kuleshov, Ana Lacoste, Stefano Lagomarsino, Alessandro Lo Giudice, Ivan López Paz, Eric Lukosi, Chaker Maazouzi, Igor Mandić, Sara Marcatili, Alysia Marino, Cédric Mathieu, Mauro Menichelli, Marko Mikuž, Arianna Morozzi, Francesco Moscatelli, Joshua Moss, Raymond Mountain, Alexander Oh, Paolo Olivero, Daniele Passeri, Heinz Pernegger, Roberto Perrino, Federico Picollo, Michal Pomorski, Renato Potenza, Arnulf Quadt, Fatah Rarbi, Alessandro Re, Michael Reichmann, Shaun Roe, Olivier Rossetto, Diego Alejandro Sanz Becerra, Christian J. Schmidt, Stephen Schnetzer, Silvio Sciortino, Andrea Scorzoni, Sally Seidel, Leonello Servoli, Dale Shane Smith, Bruno Sopko, Vit Sopko, Stefania Spagnolo, Stefan Spanier, Kevin Stenson, Robert Stone, Bjarne Stugu, Concetta Sutera, Michael Traeger, William Trischuk, Marco Truccato, Cristina Tuvè, Jaap Velthuis, Stephen Wagner, Rainer Wallny, Jianchun Wang, Norbert Wermes, Jayashani Wickramasinghe, Mahfoud Yamouni, Justas Zalieckas, Marko Zavrtanik, Kazuhiko Hara, Yoichi Ikegami, Osamu Jinnouchi, Takashi Kohriki, Shingo Mitsui, Ryo Nagai, Susumu Terada, Yoshinobu Unno

Publikováno v: Sensors, Vol 20, Iss 22, p 6648 (2020)

We measured the radiation tolerance of commercially available diamonds grown by the Chemical Vapor Deposition process by measuring the charge created by a 120 GeV hadron beam in a 50 μm pitch strip detector fabricated on each diamond sample before a

Externí odkaz: https://doaj.org/article/e1264b05b87a4899b3d1120f414af28a

In vitro Reconstitution of the S. aureus 30S Ribosomal Subunit and RbfA Factor Complex for Structural Studies

Autor: E.A. Klochkova, Dmitry S. Blokhin, Alexander Golubev, Aydar Bikmullin, Sh Z Validov, I.Sh. Khusainov, Natalia Garaeva, Marat Yusupov, Liliya I. Nurullina, Konstantin S. Usachev

Publikováno v: Biochemistry (Moscow). 85:545-552

Ribosome-binding factor A (RbfA) from Staphylococcus aureus is a cold adaptation protein that is required for the growth of pathogenic cells at low temperatures (10-15°C). RbfA is involved in the processing of 16S rRNA, as well as in the assembly an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcfea360c9be4698418c933150dfdbf5
https://doi.org/10.1134/s000629792005003x

Cryo-EM structure of the 70 initiation complex from S. aurues

Autor: I. Khusainov, Gulnara Yusupova, Konstantin S. Usachev, Sh. Validov, Lasse Jenner, A. Gabdulkhakov, B. Fatkhullin, Marat Yusupov, Alexander Golubev

Publikováno v: XXVIII Российская конференция по электронной микроскопии и VI школа молодых учёных "Современные методы электронной, зондовой микроскопии и комплементарные методы в исследованиях наноструктур и наноматериалов".

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fbab532ed120dd162f08e561cefdce36
https://doi.org/10.37795/rcem.2020.51.47.049