Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Alexander, Flügel"'
Autor:
Matthias Münchhalfen, Richard Görg, Michael Haberl, Jens Löber, Jakob Willenbrink, Laura Schwarzt, Charlotte Höltermann, Christian Ickes, Leonard Hammermann, Jan Kus, Björn Chapuy, Andrea Ballabio, Sybille D. Reichardt, Alexander Flügel, Niklas Engels, Jürgen Wienands
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Ligation of the B cell antigen receptor (BCR) initiates humoral immunity. However, BCR signaling without appropriate co-stimulation commits B cells to death rather than to differentiation into immune effector cells. How BCR activation deplet
Externí odkaz:
https://doaj.org/article/d3d3f15046064c9eadb2e5e5e120d8db
Autor:
Rouven Wannemacher, Anna Reiß, Karl Rohn, Fred Lühder, Alexander Flügel, Wolfgang Baumgärtner, Kirsten Hülskötter
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Theiler’s murine encephalomyelitis virus (TMEV) is the causative agent of TMEV-induced demyelinating disease (TMEV-IDD); a well-established animal model for the chronic progressive form of human multiple sclerosis (MS). In susceptible mice with an
Externí odkaz:
https://doaj.org/article/dc41585ec46a4ed4ac0ffeef3b24ab26
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The intracerebral infection of mice with Theiler’s murine encephalomyelitis virus (TMEV) represents a well-established animal model for multiple sclerosis (MS). Because CD28 is the main co-stimulatory molecule for the activation of T cells, we want
Externí odkaz:
https://doaj.org/article/9a686f2e54524f478050c94e5e6f5880
Autor:
Anne K. Mausberg, Fabian Szepanowski, Francesca Odoardi, Alexander Flügel, Christoph Kleinschnitz, Mark Stettner, Bernd C. Kieseier
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-9 (2018)
Abstract Background Autoimmune polyneuropathies are acquired inflammatory disorders of the peripheral nervous system (PNS) characterized by inflammation, demyelination, and axonal degeneration. Although the pathogenesis has not been fully elucidated,
Externí odkaz:
https://doaj.org/article/76ba0cc42f9c46798f02582b426670ca
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 16, p 8486 (2021)
Tamoxifen is frequently used in murine knockout systems with CreER/LoxP. Besides possible neuroprotective effects, tamoxifen is described as having a negative impact on adult neurogenesis. The present study investigated the effect of a high-dose tamo
Externí odkaz:
https://doaj.org/article/9174825627d5476683a1d10bb8914de2
Autor:
Fred Lühder, Hania Kebir, Francesca Odoardi, Tanja Litke, Maike Sonneck, Jorge Ivan Alvarez, Jan Winchenbach, Nadine Eckert, Liat Hayardeny, Ella Sorani, Dmitri Lodygin, Alexander Flügel, Alexandre Prat
Publikováno v:
Neurobiology of Disease, Vol 102, Iss , Pp 60-69 (2017)
Laquinimod is currently being tested as a therapeutic drug in multiple sclerosis. However, its exact mechanism of action is still under investigation. Tracking of fluorescently-tagged encephalitogenic T cells during experimental autoimmune encephalom
Externí odkaz:
https://doaj.org/article/bb0d65d19072434a88849b414fc214b3
Autor:
Lalit Kaurani, Md Rezaul Islam, Urs Heilbronner, Dennis M. Krüger, Jiayin Zhou, Aditi Methi, Judith Strauss, Ranjit Pradhan, Susanne Burkhardt, Tonatiuh Pena, Lena Erlebach, Anika Bühler, Monika Budde, Fanny Senner, Mojtaba Oraki Kohshour, Eva C. Schulte, Max Schmauß, Eva Z. Reininghaus, Georg Juckel, Deborah Kronenberg-Versteeg, Ivana Delalle, Francesca Odoardi, Alexander Flügel, Thomas G. Schulze, Peter Falkai, Farahnaz Sananbenesi, Andre Fischer
Schizophrenia is a psychiatric disorder that is still not readily treatable. Pharmaceutical advances in the treatment of schizophrenia have mainly focused on the protein coding part of the human genome. However, the vast majority of the human transcr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9f775bc341882cae88a4596c327d4ea
https://doi.org/10.1101/2023.03.21.533602
https://doi.org/10.1101/2023.03.21.533602
Autor:
Harri Nurmi, Britta Engelhardt, Alexander Flügel, Arianna Merlini, Sudhakar Chintharlapalli, Emilia A. Korhonen, Gou Young Koh, Urban Deutsch, Zhilin Li, Judith Strauss, Eleonoora Wihuri, Jennifer Paech, Salli Antila, Kari Alitalo
Publikováno v:
Journal of Clinical Investigation
The Journal of Clinical Investigation
The Journal of Clinical Investigation
Angiopoietin-2 (Ang2), a ligand of the endothelial Tie2 tyrosine kinase, is involved in vascular inflammation and leakage in critically ill patients. However, the role of Ang2 in demyelinating central nervous system (CNS) autoimmune diseases is unkno
Autor:
Marc, Charabati, Camille, Grasmuck, Soufiane, Ghannam, Lyne, Bourbonnière, Antoine P, Fournier, Marc-André, Lécuyer, Olivier, Tastet, Hania, Kebir, Rose-Marie, Rébillard, Chloé, Hoornaert, Elizabeth, Gowing, Sandra, Larouche, Olivier, Fortin, Camille, Pittet, Ali, Filali-Mouhim, Boaz, Lahav, Robert, Moumdjian, Alain, Bouthillier, Marc, Girard, Pierre, Duquette, Romain, Cayrol, Evelyn, Peelen, Francisco J, Quintana, Jack P, Antel, Alexander, Flügel, Catherine, Larochelle, Nathalie, Arbour, Stephanie, Zandee, Alexandre, Prat
Publikováno v:
Science translational medicine. 14(626)
The migration of circulating leukocytes into the central nervous system (CNS) is a key driver of multiple sclerosis (MS) pathogenesis. The monoclonal antibody natalizumab proved that pharmaceutically obstructing this process is an effective therapeut
Autor:
Marc Charabati, Camille Grasmuck, Soufiane Ghannam, Lyne Bourbonnière, Antoine P. Fournier, Marc-André Lécuyer, Olivier Tastet, Hania Kebir, Rose-Marie Rébillard, Chloé Hoornaert, Elizabeth Gowing, Sandra Larouche, Olivier Fortin, Camille Pittet, Ali Filali-Mouhim, Boaz Lahav, Robert Moumdjian, Alain Bouthillier, Marc Girard, Pierre Duquette, Romain Cayrol, Evelyn Peelen, Francisco J. Quintana, Jack P. Antel, Alexander Flügel, Catherine Larochelle, Nathalie Arbour, Stephanie Zandee, Alexandre Prat
Publikováno v:
Science Translational Medicine. 14
DICAM contributes to the pathogenesis of autoimmune neuroinflammation by promoting the migration of T H 17 lymphocytes across the blood-brain barrier.