Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Alexander, Brobeil"'
Autor:
Marco Gustav, Nic Gabriel Reitsam, Zunamys I. Carrero, Chiara M. L. Loeffler, Marko van Treeck, Tanwei Yuan, Nicholas P. West, Philip Quirke, Titus J. Brinker, Hermann Brenner, Loëtitia Favre, Bruno Märkl, Albrecht Stenzinger, Alexander Brobeil, Michael Hoffmeister, Julien Calderaro, Anaïs Pujals, Jakob Nikolas Kather
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-11 (2024)
Abstract In the spectrum of colorectal tumors, microsatellite-stable (MSS) tumors with DNA polymerase ε (POLE) mutations exhibit a hypermutated profile, holding the potential to respond to immunotherapy similarly to their microsatellite-instable (MS
Externí odkaz:
https://doaj.org/article/43aa367ce4a841f587e2ab532d5c55a4
Autor:
Ekaterina Nikitina, Amelie Burk‐Körner, Manuel Wiesenfarth, Elizabeth Alwers, Danijela Heide, Claudia Tessmer, Claudia Ernst, Damir Krunic, Petra Schrotz‐King, Jenny Chang‐Claude, Moritz vonWinterfeld, Esther Herpel, Alexander Brobeil, Hermann Brenner, Mathias Heikenwalder, Michael Hoffmeister, Annette Kopp‐Schneider, Timo Bund
Publikováno v:
Molecular Oncology, Vol 18, Iss 5, Pp 1076-1092 (2024)
Bovine milk and meat factors (BMMFs) are plasmid‐like DNA molecules isolated from bovine milk and serum, as well as the peritumor of colorectal cancer (CRC) patients. BMMFs have been proposed as zoonotic infectious agents and drivers of indirect ca
Externí odkaz:
https://doaj.org/article/3cd2ebb90ef14f97a8cfe5fe5f549577
Autor:
Tanwei Yuan, Durgesh Wankhede, Dominic Edelmann, Jakob Nikolas Kather, Katrin E. Tagscherer, Wilfried Roth, Melanie Bewerunge-Hudler, Alexander Brobeil, Matthias Kloor, Hendrik Bläker, Hermann Brenner, Michael Hoffmeister
Publikováno v:
EBioMedicine, Vol 105, Iss , Pp 105223- (2024)
Summary: Background: DNA methylation biomarkers in colorectal cancer (CRC) tissue hold potential as prognostic indicators. However, individual studies have yielded heterogeneous results, and external validation is largely absent. We conducted a compr
Externí odkaz:
https://doaj.org/article/518c1ff42f2c448688715029556177d7
Autor:
Omar S. M. El Nahhas, Chiara M. L. Loeffler, Zunamys I. Carrero, Marko van Treeck, Fiona R. Kolbinger, Katherine J. Hewitt, Hannah S. Muti, Mara Graziani, Qinghe Zeng, Julien Calderaro, Nadina Ortiz-Brüchle, Tanwei Yuan, Michael Hoffmeister, Hermann Brenner, Alexander Brobeil, Jorge S. Reis-Filho, Jakob Nikolas Kather
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Deep Learning (DL) can predict biomarkers from cancer histopathology. Several clinically approved applications use this technology. Most approaches, however, predict categorical labels, whereas biomarkers are often continuous measurements. W
Externí odkaz:
https://doaj.org/article/0696d137231f4079b4d6924a37f1e5c8
Autor:
Sabrina Schütz, Llorenç Solé-Boldo, Carlota Lucena-Porcel, Jochen Hoffmann, Alexander Brobeil, Anke S. Lonsdorf, Manuel Rodríguez-Paredes, Frank Lyko
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Cutaneous squamous cell carcinoma (cSCC) is a serious public health problem due to its high incidence and metastatic potential. It may progress from actinic keratosis (AK), a precancerous lesion, or the in situ carcinoma, Bowen’s disease (
Externí odkaz:
https://doaj.org/article/7dfd2b2a17394f908dbe8cf7eb3a6200
Autor:
Lukas John, Alexandra M. Poos, Alexander Brobeil, Carolina Schinke, Stefanie Huhn, Nina Prokoph, Raphael Lutz, Barbara Wagner, Maurizio Zangari, Stephan M. Tirier, Jan-Philipp Mallm, Sabrina Schumacher, Dominik Vonficht, Llorenç Solé-Boldo, Sabine Quick, Simon Steiger, Moritz J. Przybilla, Katharina Bauer, Anja Baumann, Stefan Hemmer, Christoph Rehnitz, Christian Lückerath, Christos Sachpekidis, Gunhild Mechtersheimer, Uwe Haberkorn, Antonia Dimitrakopoulou-Strauss, Philipp Reichert, Bart Barlogie, Carsten Müller-Tidow, Hartmut Goldschmidt, Jens Hillengass, Leo Rasche, Simon F. Haas, Frits van Rhee, Karsten Rippe, Marc S. Raab, Sandra Sauer, Niels Weinhold
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract In multiple myeloma spatial differences in the subclonal architecture, molecular signatures and composition of the microenvironment remain poorly characterized. To address this shortcoming, we perform multi-region sequencing on paired random
Externí odkaz:
https://doaj.org/article/1de2b57c538f40e487f459cc7a327e33
Autor:
Anke S. Lonsdorf, Dominic Edelmann, Thomas Albrecht, Alexander Brobeil, Jannik Labrenz, Moritz Johanning, Richard F. Schlenk, Benjamin Goeppert, Alexander H. Enk, Ferdinand Toberer
Publikováno v:
Acta Dermato-Venereologica, Vol 104 (2024)
Beyond established anti-programmed cell death protein 1/programmed cell death ligand 1 immunotherapy, T-cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibition motif domain (TIGIT) and its ligand CD155 are promising novel
Externí odkaz:
https://doaj.org/article/72f8575a80c34373914d45e3bb351628
Autor:
Feng Pan, Thuy D. Do, Niclas Schmitt, Dominik F. Vollherbst, Markus Möhlenbruch, Parham Tinoush, Alexander Brobeil, Vitali Koch, Götz M. Richter, Philippe L. Pereira, Hans U. Kauczor, Christof M. Sommer
Publikováno v:
CVIR Endovascular, Vol 6, Iss 1, Pp 1-19 (2023)
Abstract Purpose To present a preclinical in vivo approach for standardization and training of lymphangiography and lymphatic interventions using a pictorial review. Materials and methods Different lipiodol- and gadolinium-based lymphangiography and
Externí odkaz:
https://doaj.org/article/a3eaf567d81a45498c7add80d86fb34f
Autor:
Elizabeth Alwers, Jakob N Kather, Matthias Kloor, Alexander Brobeil, Katrin E Tagscherer, Wilfried Roth, Amelie Echle, Efrat L Amitay, Jenny Chang‐Claude, Hermann Brenner, Michael Hoffmeister
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 9, Iss 2, Pp 129-136 (2023)
Abstract In addition to the traditional staging system in colorectal cancer (CRC), the Immunoscore® has been proposed to characterize the level of immune infiltration in tumor tissue and as a potential prognostic marker. The aim of this study was to
Externí odkaz:
https://doaj.org/article/4c9e90af24084aecaf17e369708cd7af
Autor:
Omar S. M. El Nahhas, Chiara M. L. Loeffler, Zunamys I. Carrero, Marko van Treeck, Fiona R. Kolbinger, Katherine J. Hewitt, Hannah S. Muti, Mara Graziani, Qinghe Zeng, Julien Calderaro, Nadina Ortiz-Brüchle, Tanwei Yuan, Michael Hoffmeister, Hermann Brenner, Alexander Brobeil, Jorge S. Reis-Filho, Jakob Nikolas Kather
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/9b93b1e49d224781887ac4c0c5dc644d