Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Alexa N. Avitto"'
Autor:
Hannah J. Barbian, Andrew Jesse Connell, Alexa N. Avitto, Ronnie M. Russell, Andrew G. Smith, Madhurima S. Gundlapally, Alexander L. Shazad, Yingying Li, Frederic Bibollet‐Ruche, Emily E. Wroblewski, Deus Mjungu, Elizabeth V. Lonsdorf, Fiona A. Stewart, Alexander K. Piel, Anne E. Pusey, Paul M. Sharp, Beatrice H. Hahn
Publikováno v:
Ecology and Evolution, Vol 8, Iss 16, Pp 7946-7963 (2018)
Abstract Short tandem repeats (STRs), also known as microsatellites, are commonly used to noninvasively genotype wild‐living endangered species, including African apes. Until recently, capillary electrophoresis has been the method of choice to dete
Externí odkaz:
https://doaj.org/article/1eb63431f6a14f08bdd03d0f9ed1ed4c
Autor:
Weimin Liu, Scott Sherrill-Mix, Gerald H. Learn, Erik J. Scully, Yingying Li, Alexa N. Avitto, Dorothy E. Loy, Abigail P. Lauder, Sesh A. Sundararaman, Lindsey J. Plenderleith, Jean-Bosco N. Ndjango, Alexander V. Georgiev, Steve Ahuka-Mundeke, Martine Peeters, Paco Bertolani, Jef Dupain, Cintia Garai, John A. Hart, Terese B. Hart, George M. Shaw, Paul M. Sharp, Beatrice H. Hahn
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Unlike chimpanzees and gorillas, bonobos have not been found infected by malaria parasites in the wild. Here, Liu et al. report more thorough survey and sequencing results showing that bonobos host malaria parasites, including a yet-unknown species,
Externí odkaz:
https://doaj.org/article/dcde71d74a4544ac9856a87833ed478f
Autor:
Jenny A. Greig, Hanying Yan, Thomas Furmanak, Alexa N. Avitto, Caitlin Latshaw, Camilo Breton, Melanie K. Smith, James M. Wilson
Publikováno v:
Mol Ther
Our group previously used adeno-associated viral vectors (AAVs) to express an engineered meganuclease specific for a sequence in the PCSK9 gene (M2PCSK9), a clinical target for treating coronary heart disease. Upon testing this nuclease in non-human
Autor:
Preston A. Marx, William J. Kohler, Sandrine François-Souquiere, Alexander V. Georgiev, Weimin Liu, Ronnie M. Russell, Stephanie Trimboli, Scott Sherrill-Mix, Ronald G. Collman, Beatrice H. Hahn, Paul M. Sharp, Alex K. Piel, Paco Bertolani, Martine Peeters, Dorothy E. Loy, Marcos V. P. Gondim, Ahidjo Ayouba, Amandine Esteban, George M. Shaw, Lindsey J. Plenderleith, Volker Sommer, Frederic Bibollet-Ruche, Jesse Connell, Terese B. Hart, Fiona A. Stewart, Andrew G. Smith, Vanessa M. Hirsch, William M. Switzer, John Hart, Alexa N. Avitto, Katherine S. Wetzel, Yingying Li, Richard A. Miller
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Russell, R M, Bibollet-Ruche, F, Liu, W, Sherrill-Mix, S, Li, Y, Connell, J, Loy, D E, Trimboli, S, Smith, A G, Avitto, A N, Gondim, M V P, Plenderleith, L J, Wetzel, K S, Collman, R G, Ayouba, A, Esteban, A, Peeters, M, Kohler, W J, Miller, R A, François-Souquiere, S, Switzer, W M, Hirsch, V M, Marx, P A, Piel, A K, Stewart, F A, Georgiev, A V, Sommer, V, Bertolani, P, Hart, J A, Hart, T B, Shaw, G M, Sharp, P M & Hahn, B H 2021, ' CD4 receptor diversity represents an ancient protection mechanism against primate lentiviruses ', Proceedings of the National Academy of Sciences, vol. 118, no. 13, e2025914118 . https://doi.org/10.1073/pnas.2025914118
Russell, R M, Bibollet-Ruche, F, Liu, W, Sherrill-Mix, S, Li, Y, Connell, J, Loy, D E, Trimboli, S, Smith, A G, Avitto, A N, Gondim, M V P, Plenderleith, L J, Wetzel, K S, Collman, R G, Ayouba, A, Esteban, A, Peeters, M, Kohler, W J, Miller, R A, François-Souquiere, S, Switzer, W M, Hirsch, V M, Marx, P A, Piel, A K, Stewart, F A, Georgiev, A V, Sommer, V, Bertolani, P, Hart, J A, Hart, T B, Shaw, G M, Sharp, P M & Hahn, B H 2021, ' CD4 receptor diversity represents an ancient protection mechanism against primate lentiviruses ', Proceedings of the National Academy of Sciences, vol. 118, no. 13, e2025914118 . https://doi.org/10.1073/pnas.2025914118
Significance The CD4 protein of primates has undergone rapid diversification, but the reasons for this remain unknown. Here we show that within-species diversity of the HIV/simian immunodeficiency virus (SIV) envelope (Env) binding (D1) domain is com
Autor:
Robert F. Siliciano, Weimin Liu, Alexa N. Avitto, Michel C. Nussenzweig, Yehuda Z. Cohen, Paul M. Sharp, Michael S. Saag, Ronnie M. Russell, Luis J. Montaner, Frederic Bibollet-Ruche, Ronald G. Collman, George M. Shaw, Pierre Pellegrino, Sonya L. Heath, Julio C. C. Lorenzi, Jesse Connell, Ian Williams, Stephanie Trimboli, Andrew G. Smith, M. Alexandra Monroy, Scott Sherrill-Mix, Yingying Li, Beatrice H. Hahn, Janet M. Siliciano, D. Brenda Salantes, Lindsey J. Plenderleith, Emmanouil Papasavvas, Angharad E. Fenton-May, Julia DeVoto, Katharine J. Bar, Marina Caskey, Marcos V. P. Gondim, Persephone Borrow, Felicity Mampe
Publikováno v:
Gondim, M V P, Sherrill-Mix, S, Bibollet-Ruche, F, Russell, R M, Trimboli, S, Smith, A G, Li, Y, Liu, W, Avitto, A N, DeVoto, J C, Connell, J, Fenton-May, A E, Pellegrino, P, Williams, I, Papasavvas, E, Lorenzi, J C C, Brenda Salantes, D, Mampe, F, Alexandra Monroy, M, Cohen, Y Z, Heath, S, Saag, M S, Montaner, L J, Collman, R G, Siliciano, J M, Siliciano, R F, Plenderleith, L J, Sharp, P M, Caskey, M, Nussenzweig, M C, Shaw, G M, Borrow, P, Bar, K J & Hahn, B H 2021, ' Heightened resistance to host type 1 interferons characterizes HIV-1 at transmission and after antiretroviral therapy interruption ', Science Translational Medicine, vol. 13, no. 576, eabd8179 . https://doi.org/10.1126/SCITRANSLMED.ABD8179
Sci Transl Med
Sci Transl Med
Type 1 interferons (IFN-I) are potent innate antiviral effectors that constrain HIV-1 transmission. However, harnessing these cytokines for HIV-1 cure strategies has been hampered by an incomplete understanding of their antiviral activities at later
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd61e6b06a1340de5cdaf3c9a30f3230
https://hdl.handle.net/20.500.11820/a6051f01-6cf5-434d-b22c-8486e3fd60c2
https://hdl.handle.net/20.500.11820/a6051f01-6cf5-434d-b22c-8486e3fd60c2
Autor:
Luis J. Montaner, Robert F. Siliciano, Ronnie M. Russell, Michel C. Nussenzweig, Marcos V. P. Gondim, Alexa N. Avitto, Weimin Liu, Julia DeVoto, Katharine J. Bar, Ian Williams, Persephone Borrow, Janet M. Siliciano, Jesse Connell, Ronald G. Collman, Marina Caskey, Yehuda Z. Cohen, D. Brenda Salantes, Stephanie Trimboli, M. Alexandra Monroy, Paul M. Sharp, Sonya L. Heath, Felicity Mampe, Michael S. Saag, George M. Shaw, Emmanouil Papasavvas, Angharad E. Fenton-May, Frederic Bibollet-Ruche, Julio C. C. Lorenzi, Yingying Li, Andrew G. Smith, Pierre Pellegrino, Scott Sherrill-Mix, Beatrice H. Hahn, Lindsey J. Plenderleith
Type 1 interferons (IFN-I) are potent innate antiviral effectors that constrain HIV-1 transmission. However, harnessing these cytokines for HIV-1 cure strategies has been hampered by an incomplete understanding of their anti-viral activities at later
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c3bde55476e3a75454c4ddb99c93f51
Autor:
Fiona A. Stewart, Hannah J. Barbian, Yingying Li, Frederic Bibollet-Ruche, Anne E. Pusey, Alex K. Piel, Deus Mjungu, Andrew G. Smith, Paul M. Sharp, Beatrice H. Hahn, Alexander L. Shazad, Ronnie M. Russell, Emily E. Wroblewski, Madhurima S. Gundlapally, Andrew Connell, Elizabeth V. Lonsdorf, Alexa N. Avitto
Publikováno v:
Ecology and Evolution, Vol 8, Iss 16, Pp 7946-7963 (2018)
Barbian, H J, Connell, A J, Avitto, A N, Russell, R M, Smith, A G, Gundlapally, M S, Shazad, A L, Li, Y, Bibollet-Ruche, F, Wroblewski, E E, Mjungu, D, Lonsdorf, E V, Stewart, F A, Piel, A K, Pusey, A E, Sharp, P M & Hahn, B H 2018, ' CHIIMP : An automated high-throughput microsatellite genotyping platform reveals greater allelic diversity in wild chimpanzees ', International Journal of Business Innovation and Research, vol. 8, no. 16, pp. 7946-7963 . https://doi.org/10.1002/ece3.4302
Barbian, H J, Connell, A J, Avitto, A N, Russell, R M, Smith, A G, Gundlapally, M S, Shazad, A L, Li, Y, Bibollet-Ruche, F, Wroblewski, E E, Mjungu, D, Lonsdorf, E V, Stewart, F A, Piel, A K, Pusey, A E, Sharp, P M & Hahn, B H 2018, ' CHIIMP : An automated high-throughput microsatellite genotyping platform reveals greater allelic diversity in wild chimpanzees ', International Journal of Business Innovation and Research, vol. 8, no. 16, pp. 7946-7963 . https://doi.org/10.1002/ece3.4302
Short tandem repeats (STRs), also known as microsatellites, are commonly used to noninvasively genotype wild‐living endangered species, including African apes. Until recently, capillary electrophoresis has been the method of choice to determine the
Autor:
Alfred K. Njamnshi, Charles Fokunang, Weimin Liu, Meagan A. Rubel, Paul M. Sharp, Dorothy E. Loy, Beatrice H. Hahn, Eric Mbunwe, Alessia Ranciaro, Yingying Li, Gerald H. Learn, Sarah A. Tishkoff, Alexa N. Avitto
Publikováno v:
International Journal for Parasitology. 48:531-542
African apes are endemically infected with numerous Plasmodium spp. including close relatives of human Plasmodium falciparum, Plasmodium vivax, Plasmodium ovale, and Plasmodium malariae. Although these ape parasites are not believed to pose a zoonoti
Autor:
Paul M. Sharp, Gerald H. Learn, Fabian H. Leendertz, Sébastien Calvignac-Spencer, Andreas Sachse, Ahidjo Ayouba, Alexa N. Avitto, Sheri Speede, Yi Jun Chen, Oscar A. MacLean, Martine Peeters, Alex L. K. Morgan, Stephanie Trimboli, Dorothy E. Loy, Wai-Hong Tham, Julian C. Rayner, Sesh A. Sundararaman, Jakub Gruszczyk, Jasmin Giles, Lindsey J. Plenderleith, Beatrice H. Hahn, Yingying Li, Weimin Liu
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Loy, D E, Plenderleith, L J, Sundararaman, S A, Liu, W, Gruszczyk, J, Chen, Y J, Trimboli, S, Learn, G H, MacLean, O A, Morgan, A L K, Li, Y, Avitto, A N, Giles, J, Calvignac-Spencer, S, Sachse, A, Leendertz, F H, Speede, S, Ayouba, A, Peeters, M, Rayner, J C, Tham, W H, Sharp, P M & Hahn, B H 2018, ' Evolutionary history of human Plasmodium vivax revealed by genome-wide analyses of related ape parasites ', Proceedings of the National Academy of Sciences, vol. 115, no. 36, pp. E8450-E8459 . https://doi.org/10.1073/pnas.1810053115
Loy, D E, Plenderleith, L J, Sundararaman, S A, Liu, W, Gruszczyk, J, Chen, Y J, Trimboli, S, Learn, G H, MacLean, O A, Morgan, A L K, Li, Y, Avitto, A N, Giles, J, Calvignac-Spencer, S, Sachse, A, Leendertz, F H, Speede, S, Ayouba, A, Peeters, M, Rayner, J C, Tham, W H, Sharp, P M & Hahn, B H 2018, ' Evolutionary history of human Plasmodium vivax revealed by genome-wide analyses of related ape parasites ', Proceedings of the National Academy of Sciences, vol. 115, no. 36, pp. E8450-E8459 . https://doi.org/10.1073/pnas.1810053115
Significance Chimpanzees, bonobos, and gorillas harbor close relatives of human Plasmodium vivax, but current knowledge of these parasites is limited to a small number of gene fragments derived almost exclusively from mitochondrial DNA. We compared n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64cadc928ab3dc9ebb3f122bef16d055
http://www.documentation.ird.fr/hor/fdi:010073985
http://www.documentation.ird.fr/hor/fdi:010073985
Autor:
Lindsey J. Plenderleith, Steve Ahuka-Mundeke, Martine Peeters, Abigail Lauder, Paul M. Sharp, Weimin Liu, Scott Sherrill-Mix, Terese B. Hart, Beatrice H. Hahn, Gerald H. Learn, George M. Shaw, Jef Dupain, Cintia Garai, Paco Bertolani, Alexander V. Georgiev, Jean Bosco N. Ndjango, Yingying Li, Sesh A. Sundararaman, Dorothy E. Loy, Erik J. Scully, John Hart, Alexa N. Avitto
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Nature Communications
Liu, W, Sherrill-Mix, S, Learn, G H, Scully, E J, Li, Y, Avitto, A N, Loy, D E, Lauder, A P, Sundararaman, S A, Plenderleith, L J, Ndjango, J B N, Georgiev, A V, Ahuka-Mundeke, S, Peeters, M, Bertolani, P, Dupain, J, Garai, C, Hart, J A, Hart, T B, Shaw, G M, Sharp, P M & Hahn, B H 2017, ' Wild bonobos host geographically restricted malaria parasites including a putative new Laverania species ', Nature Communications, vol. 8, no. 1, 1635 . https://doi.org/10.1038/s41467-017-01798-5
Nature Communications
Liu, W, Sherrill-Mix, S, Learn, G H, Scully, E J, Li, Y, Avitto, A N, Loy, D E, Lauder, A P, Sundararaman, S A, Plenderleith, L J, Ndjango, J B N, Georgiev, A V, Ahuka-Mundeke, S, Peeters, M, Bertolani, P, Dupain, J, Garai, C, Hart, J A, Hart, T B, Shaw, G M, Sharp, P M & Hahn, B H 2017, ' Wild bonobos host geographically restricted malaria parasites including a putative new Laverania species ', Nature Communications, vol. 8, no. 1, 1635 . https://doi.org/10.1038/s41467-017-01798-5
Malaria parasites, though widespread among wild chimpanzees and gorillas, have not been detected in bonobos. Here, we show that wild-living bonobos are endemically Plasmodium infected in the eastern-most part of their range. Testing 1556 faecal sampl