Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Alexa G. Michel"'
Autor:
Jun Tian, Jonathan H. Chen, Sherry X. Chao, Karin Pelka, Marios Giannakis, Julian Hess, Kelly Burke, Vjola Jorgji, Princy Sindurakar, Jonathan Braverman, Arnav Mehta, Tomonori Oka, Mei Huang, David Lieb, Maxwell Spurrell, Jill N. Allen, Thomas A. Abrams, Jeffrey W. Clark, Andrea C. Enzinger, Peter C. Enzinger, Samuel J. Klempner, Nadine J. McCleary, Jeffrey A. Meyerhardt, David P. Ryan, Matthew B. Yurgelun, Katie Kanter, Emily E. Van Seventer, Islam Baiev, Gary Chi, Joy Jarnagin, William B. Bradford, Edmond Wong, Alexa G. Michel, Isobel J. Fetter, Giulia Siravegna, Angelo J. Gemma, Arlene Sharpe, Shadmehr Demehri, Rebecca Leary, Catarina D. Campbell, Omer Yilmaz, Gad A. Getz, Aparna R. Parikh, Nir Hacohen, Ryan B. Corcoran
Publikováno v:
Nature Medicine. 29:458-466
While BRAF inhibitor combinations with EGFR and/or MEK inhibitors have improved clinical efficacy in BRAFV600E colorectal cancer (CRC), response rates remain low and lack durability. Preclinical data suggest that BRAF/MAPK pathway inhibition may augm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4503ae8a502bac127cbff0a3ff92547
https://doi.org/10.1038/s41591-022-02181-8
https://doi.org/10.1038/s41591-022-02181-8
Autor:
Ryan B. Corcoran, Rebecca S. Heist, Aaron N. Hata, Liron Bar-Peled, Giulia Siravegna, Jochen K. Lennerz, Samuel J. Klempner, Justin F. Gainor, Dejan Juric, Islam Baiev, Mustafa Sakhi, Katerina A. Fella, Mohammed U. Syed, Alexa G. Michel, Lesli A. Kiedrowski, Junbing Zhang, Meagan B. Ryan, Chendi Li, Jessica J. Lin, Noritaka Tanaka
Mutant-selective KRASG12C inhibitors, such as MRTX849 (adagrasib) and AMG 510 (sotorasib), have demonstrated efficacy in KRASG12C-mutant cancers, including non–small cell lung cancer (NSCLC). However, mechanisms underlying clinical acquired resista
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b6aa2acd4b997a9e54783ae8dd826d4
https://doi.org/10.1158/2159-8290.c.6549266
https://doi.org/10.1158/2159-8290.c.6549266
Autor:
Ryan B. Corcoran, Rebecca S. Heist, Aaron N. Hata, Liron Bar-Peled, Giulia Siravegna, Jochen K. Lennerz, Samuel J. Klempner, Justin F. Gainor, Dejan Juric, Islam Baiev, Mustafa Sakhi, Katerina A. Fella, Mohammed U. Syed, Alexa G. Michel, Lesli A. Kiedrowski, Junbing Zhang, Meagan B. Ryan, Chendi Li, Jessica J. Lin, Noritaka Tanaka
Supplementary Materials
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0a96c09e6d29bcd6766cf1adc0dadec
https://doi.org/10.1158/2159-8290.22540040.v1
https://doi.org/10.1158/2159-8290.22540040.v1
Autor:
Islam Baiev, Jochen K. Lennerz, Lesli A. Kiedrowski, Mohammed Usman Syed, Chendi Li, Rebecca S. Heist, Samuel J. Klempner, Dejan Juric, Aaron N. Hata, Mustafa Sakhi, Katerina A. Fella, Ryan B. Corcoran, Alexa G. Michel, Justin F. Gainor, Junbing Zhang, Liron Bar-Peled, Jessica J. Lin, Meagan B. Ryan, Noritaka Tanaka, Giulia Siravegna
Publikováno v:
Cancer Discovery. 11:1913-1922
Mutant-selective KRASG12C inhibitors, such as MRTX849 (adagrasib) and AMG 510 (sotorasib), have demonstrated efficacy in KRASG12C-mutant cancers, including non–small cell lung cancer (NSCLC). However, mechanisms underlying clinical acquired resista
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6762e770e5b640e1b66d7c71679f567
https://doi.org/10.1158/2159-8290.cd-21-0365
https://doi.org/10.1158/2159-8290.cd-21-0365
Autor:
Osamu Sakai, Peter M. Sadow, Ryan B. Corcoran, Jeremy D. Richmon, Daniel L. Faden, Annie W. Chan, Adam Z. Bard, Julia Thierauf, Wei Wang, Giulia Siravegna, A. John Iafrate, Connor J O'Boyle, Kevin S. Emerick, Daniel G. Deschler, Simon K Perry, Lori J. Wirth, William C. Faquin, Alexa G. Michel, Jarrod Stein, Shohreh Varmeh, Jochen K. Lennerz, Mark A. Varvares, John W. Clark, Natalia Queenan, Derrick T. Lin, Jong C. Park, Vanessa Carlota Andreu Arasa
Publikováno v:
Clin Cancer Res
Purpose: HPV-associated head and neck squamous cell carcinoma (HPV+HNSCC) is the most common HPV-associated malignancy in the United States and continues to increase in incidence. Current diagnostic approaches for HPV+HNSCC rely on tissue biopsy foll
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a8d1ea1e3b65fc5b019e35f483a1c71
https://pubmed.ncbi.nlm.nih.gov/35285945
https://pubmed.ncbi.nlm.nih.gov/35285945
Autor:
Noritaka, Tanaka, Jessica J, Lin, Chendi, Li, Meagan B, Ryan, Junbing, Zhang, Lesli A, Kiedrowski, Alexa G, Michel, Mohammed U, Syed, Katerina A, Fella, Mustafa, Sakhi, Islam, Baiev, Dejan, Juric, Justin F, Gainor, Samuel J, Klempner, Jochen K, Lennerz, Giulia, Siravegna, Liron, Bar-Peled, Aaron N, Hata, Rebecca S, Heist, Ryan B, Corcoran
Publikováno v:
Cancer discovery. 11(8)
Mutant-selective KRAS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::85063ff64e72d0a9b773245fec1396ce
https://pubmed.ncbi.nlm.nih.gov/34344756
https://pubmed.ncbi.nlm.nih.gov/34344756