Dlk1 dosage regulates hippocampal neurogenesis and cognition

Autor: Valter Tucci, Anne C. Ferguson-Smith, Sacri R. Ferrón, José Luis Trejo, Giorgio Vallortigara, Ana Perez-Villalba, Alexa E. Horner, Lisa M. Saksida, Raquel Montalbán-Loro, Timothy J. Bussey, Glenda Lassi, Esteban Jiménez-Villalba, Anna Lozano-Ureña, Marika Charalambous

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Proceedings of the National Academy of Sciences of the United States of America
Brain and Mind Institute Researchers' Publications

Significance Generation of new neurons occurs normally in the adult brain in two locations: the subventricular zone (SVZ) in the walls of the lateral ventricles and the subgranular zone (SGZ) in the dentate gyrus (DG) of the hippocampus. Neurogenesis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46d5798281d223755a781bb108c4e4ee
http://hdl.handle.net/10261/273154

Learning and reaction times in mouse touchscreen tests are differentially impacted by mutations in genes encoding postsynaptic interacting proteins SYNGAP1, NLGN3, DLGAP1, DLGAP2 and SHANK2

Autor: Alexa E, Horner, Rebecca H, Norris, Robbie, McLaren-Jones, Liam, Alexander, Noboru H, Komiyama, Seth G N, Grant, Jess, Nithianantharajah, Maksym V, Kopanitsa

Publikováno v: Genes, brain, and behaviorREFERENCES. 20(1)

The postsynaptic terminal of vertebrate excitatory synapses contains a highly conserved multiprotein complex that comprises neurotransmitter receptors, cell-adhesion molecules, scaffold proteins and enzymes, which are essential for brain signalling a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bafe81d968fd296596289f5dc457e84b
https://pubmed.ncbi.nlm.nih.gov/33347690

Haploinsufficiency of EHMT1 improves pattern separation and increases hippocampal cell proliferation

Autor: Catharina E.E.M. Van der Zee, Nael Nadif Kasri, Tjitske Kleefstra, Jeffrey C. Glennon, Houshang Amiri, Charlotte G G M Pauwels, Alexa E. Horner, Hans van Bokhoven, Lisa M. Saksida, Maksym V. Kopanitsa, Marco Benevento, Charlotte A. Oomen, Seth G. N. Grant, Monica Frega, Timothy J. Bussey, Tessa Jacobs

Publikováno v: Benevento, M, Oomen, C A, Horner, A E, Amiri, H, Jacobs, T, Pauwels, C, Frega, M, Kleefstra, T, Kopanitsa, M V, Grant, S, Bussey, T J, Saksida, L M, Van der Zee, C E E M, van Bokhoven, H, Glennon, J C & Kasri, N N 2017, ' Haploinsufficiency of EHMT1 improves pattern separation and increases hippocampal cell proliferation ', Scientific Reports . https://doi.org/10.1038/srep40284
Scientific Reports, 7
Scientific Reports
Scientific reports, 7:40284. Nature Publishing Group
Brain and Mind Institute Researchers' Publications

Heterozygous mutations or deletions of the human Euchromatin Histone Methyltransferase 1 (EHMT1) gene are the main causes of Kleefstra syndrome, a neurodevelopmental disorder that is characterized by impaired memory, autistic features and mostly seve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b64fa0630fdc8b7e8230f8f94559c4c
https://hdl.handle.net/20.500.11820/858a6b47-d587-443a-8418-6ebfd5c4443b

A touch screen-automated cognitive test battery reveals impaired attention, memory abnormalities, and increased response inhibition in the TgCRND8 mouse model of Alzheimer's disease

Autor: Carola Romberg, Timothy J. Bussey, Alexa E. Horner, Lisa M. Saksida

Publikováno v: Neurobiology of Aging

Transgenic mouse models of Alzheimer's disease (AD) with abundant β-amyloid develop memory impairments. However, multiple nonmnemonic cognitive domains such as attention and executive control are also compromised early in AD individuals, but have no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b91bcfa1a015d4d5db79dbe2808dd243

The touchscreen operant platform for testing learning and memory in rats and mice

Autor: Christopher J. Heath, Charlotte A. Oomen, Simon R. O. Nilsson, Timothy J. Bussey, Johan Alsiö, Brianne A. Kent, Andrew Holmes, Alexa E. Horner, Chi Hun Kim, Lisa M. Saksida, Martha Hvoslef-Eide

Publikováno v: Nature Protocols, 8, 1961-84
Nature Protocols; Vol 8
Nature Protocols, 8, 10, pp. 1961-84
Brain and Mind Institute Researchers' Publications

Item does not contain fulltext An increasingly popular method of assessing cognitive functions in rodents is the automated touchscreen platform, on which a number of different cognitive tests can be run in a manner very similar to touchscreen methods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c13b9cbf91d512d0dd4195d1ee240c06
http://hdl.handle.net/2066/126155