Zobrazeno 1 - 10
of 381
pro vyhledávání: '"Alexa B Schrock"'
Autor:
Vamsi Parimi, Khaled Tolba, Natalie Danziger, Zheng Kuang, Daokun Sun, Douglas I. Lin, Matthew C. Hiemenz, Alexa B. Schrock, Jeffrey S. Ross, Geoffrey R. Oxnard, Richard S. P. Huang
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-8 (2023)
Abstract In this study, we report the clinicopathologic and genomic profiles of 891 patients with RET fusion driven advanced solid tumors. All patient samples were tested using a tissue-based DNA hybrid capture next generation sequencing (NGS) assay
Externí odkaz:
https://doaj.org/article/91c1ba901dc249f3ae1af6da4be2810e
Autor:
Jessica K. Lee, Smruthy Sivakumar, Alexa B. Schrock, Russell Madison, David Fabrizio, Ole Gjoerup, Jeffrey S. Ross, Garrett M. Frampton, Pavel Napalkov, Meagan Montesion, Jennifer L. Schutzman, Xin Ye, Priti S. Hegde, Misako Nagasaka, Geoffrey R. Oxnard, Ethan S. Sokol, Sai-Hong Ignatius Ou, Zhen Shi
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-14 (2022)
Abstract Recent clinical development of KRAS inhibitors has heightened interest in the genomic landscape of KRAS-altered cancers. We performed a pan-cancer analysis of KRAS-altered samples from 426,706 adult patients with solid or hematologic maligna
Externí odkaz:
https://doaj.org/article/127f5104a768437896be06715f4fd5c4
Autor:
Shannon S. Zhang, MD, Alexa B. Schrock, PhD, Misako Nagasaka, MD PhD, Sai-Hong Ignatius Ou, MD, PhD
Publikováno v:
JTO Clinical and Research Reports, Vol 4, Iss 1, Pp 100453- (2023)
Externí odkaz:
https://doaj.org/article/42bf59772e3b4a79b0a1df9d44054573
Autor:
Andrea Necchi, Giuseppe Basile, Filippo Pederzoli, Marco Bandini, Petros Grivas, Gennady Bratslavsky, Philippe E. Spiess, J. Keith Killian, Douglas I. Lin, Erik Williams, Shakti Ramkissoon, Eric A. Severson, Brian M. Alexander, Jeffrey Venstrom, Prasanth Reddy, Kimberley McGregor, Julia A. Elvin, Alexa B. Schrock, Dean V. Pavlick, Dexter X. Jin, Sally E. Trabucco, Natalie Danzinger, Jeffrey S. Ross
Publikováno v:
Société Internationale d’Urologie Journal, Vol 2, Iss 4, Pp 216-228 (2021)
BackgroundAdult primary retroperitoneal sarcomas (RPSs) are a group of heterogeneous tumors with different histological subtypes. Comprehensive genomic profiling (CGP) analyses have recently provided significant insights into the biology of sarcomas
Externí odkaz:
https://doaj.org/article/25378e6a34274358be41fcc2afedd659
Autor:
Shannon S. Zhang, MD, Jessica K. Lee, MSc, Hanna Tukachinsky, PhD, Alexa B. Schrock, PhD, Misako Nagasaka, MD, PhD, Sai-Hong Ignatius Ou, MD, PhD
Publikováno v:
JTO Clinical and Research Reports, Vol 3, Iss 9, Pp 100387- (2022)
Introduction: Germline CHEK2 mutations are rare and have not been associated with increased risk of NSCLC. Methods: We identified two sequential primary NSCLCs harboring distinct actionable driver alterations (EGFR E746 _S752 delinsV and CD74-ROS1) i
Externí odkaz:
https://doaj.org/article/e5774861fb6d4b509b5508a9a6e29a18
Autor:
Zhenfang Du, Benjamin P. Brown, Soyeon Kim, Donna Ferguson, Dean C. Pavlick, Gowtham Jayakumaran, Ryma Benayed, Jean-Nicolas Gallant, Yun-Kai Zhang, Yingjun Yan, Monica Red-Brewer, Siraj M. Ali, Alexa B. Schrock, Ahmet Zehir, Marc Ladanyi, Adam W. Smith, Jens Meiler, Christine M. Lovly
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
An EGFR mutant with kinase domain duplication (EGFR-KDD) was previously identified in an index patient, but the functional and therapeutic implications remain unclear. Here, the authors show that KDD occurs in other ErbB receptors in multiple cancers
Externí odkaz:
https://doaj.org/article/b948db7f0a2649d5908bbadfe529545e
Autor:
Jonathan W. Riess, Shaila Rahman, Waleed Kian, Claire Edgerly, Andreas M. Heilmann, Russell Madison, Shakti H. Ramkissoon, Shai Shlomi Klaitman, Jon H. Chung, Sally E. Trabucco, Dexter X. Jin, Brian M. Alexander, Samuel J. Klempner, Lee A. Albacker, Garrett M. Frampton, Laila C. Roisman, Vincent A. Miller, Jeffrey S. Ross, Alexa B. Schrock, Jeffrey P. Gregg, Nir Peled, Ethan S. Sokol, Siraj M. Ali
Publikováno v:
Translational Oncology, Vol 14, Iss 10, Pp 101184- (2021)
Background: The translocation t(15:19) produces the oncogenic BRD4-NUT fusion which is pathognomonic for NUT carcinoma (NC), which is a rare, but extremely aggressive solid tumor. Comprehensive genomic profiling (CGP) by hybrid-capture based next gen
Externí odkaz:
https://doaj.org/article/f78f81cbdd204e1789f4f2191a1fc032
Autor:
Barbara J. Gitlitz, MD, Silvia Novello, MD, PhD, Tiziana Vavalà, MD, Marisa Bittoni, PhD, Alicia Sable-Hunt, RN, MBA, Dean Pavlick, BS, Robert Hsu, MD, S. Lani Park, PhD, MPH, Ruthia Chen, BA, Matthew Cooke, BA, Amy Moore, PhD, Alexa B. Schrock, PhD, Joan H. Schiller, MD, Bonnie J. Addario, Geoffrey R. Oxnard, MD
Publikováno v:
JTO Clinical and Research Reports, Vol 2, Iss 7, Pp 100194- (2021)
Introduction: Lung adenocarcinomas in young patients (
Externí odkaz:
https://doaj.org/article/01195660439e4b838be16ffce4fceb8b
Autor:
Smruthy Sivakumar, Jessica K Lee, Jay A Moore, Julia Hopkins, Justin Y Newberg, Russell Madison, Ryon Graf, Alexa B Schrock, Erin Kobetz, Randy Vince, Idalid Franco, Crystal Seldon, Garrett M Frampton, Jennifer Mills, Jeffrey Venstrom, Brandon A Mahal
Publikováno v:
The Lancet Digital Health. 5:e380-e389
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b025156ef457f3c2d7032629381fe05
https://doi.org/10.1016/s2589-7500(23)00053-5
https://doi.org/10.1016/s2589-7500(23)00053-5
Autor:
Viola W. Zhu, MD, PhD, Misako Nagasaka, MD, Russell Madison, BA, Alexa B. Schrock, PhD, Jean Cui, PhD, Sai-Hong Ignatius Ou, MD, PhD
Publikováno v:
JTO Clinical and Research Reports, Vol 2, Iss 1, Pp 100116- (2021)
Lorlatinib is a third-generation ALK inhibitor that can overcome the largest number of acquired ALK resistance mutations, including the solvent-front mutation G1202R. Here, we report, for the first time, a novel, sequentially-evolved EML4-ALK variant
Externí odkaz:
https://doaj.org/article/0f88699f4ca44685b12f532982b48a21