Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Alexa A. Pragman"'
Autor:
Alexa A. Pragman, Shane W. Hodgson, Tianhua Wu, Allison Zank, Rosemary F. Kelly, Cavan S. Reilly, Chris H. Wendt
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-12 (2024)
Abstract Rationale The lung microbiome is an inflammatory stimulus whose role in the development of lung malignancies is incompletely understood. We hypothesized that the lung microbiome associates with multiple clinical factors, including the presen
Externí odkaz:
https://doaj.org/article/04fd9f7fa0c54d92a89e12c8b857644d
Autor:
Alexa A. Pragman, Shane W. Hodgson, Tianhua Wu, Allison Zank, Cavan S. Reilly, Chris H. Wendt
Publikováno v:
ERJ Open Research, Vol 10, Iss 1 (2024)
Background The lung microbiome is an inflammatory stimulus whose role in COPD pathogenesis is incompletely understood. We hypothesised that the frequent exacerbator phenotype is associated with decreased α-diversity and increased lung inflammation.
Externí odkaz:
https://doaj.org/article/43c2a485cb2746799afdcff7fd6cddd3
Autor:
Alexa A. Pragman, Katherine A. Knutson, Trevor J. Gould, Richard E. Isaacson, Cavan S. Reilly, Chris H. Wendt
Publikováno v:
Respiratory Research, Vol 20, Iss 1, Pp 1-14 (2019)
Abstract Background Chronic obstructive pulmonary disease (COPD) frequent exacerbators (FE) suffer increased morbidity and mortality compared to infrequent exacerbators (IE). The association between the oral and sputum microbiota and exacerbation phe
Externí odkaz:
https://doaj.org/article/8ca42359042c460f8f7bc80915e88bdb
Autor:
Alexa A. Pragman, Tianmeng Lyu, Joshua A. Baller, Trevor J. Gould, Rosemary F. Kelly, Cavan S. Reilly, Richard E. Isaacson, Chris H. Wendt
Publikováno v:
Microbiome, Vol 6, Iss 1, Pp 1-19 (2018)
Abstract Background Oral taxa are often found in the chronic obstructive pulmonary disease (COPD) lung microbiota, but it is not clear if this is due to a physiologic process such as aspiration or experimental contamination at the time of specimen co
Externí odkaz:
https://doaj.org/article/9d9275acd00f482c9481ff733501cbaa
Autor:
Alexa A Pragman, Katherine A Knutson, Trevor J Gould, Shane W Hodgson, Richard E Isaacson, Cavan S Reilly, Chris H Wendt
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0219962 (2019)
BackgroundChronic obstructive pulmonary disease (COPD) is an inflammatory lung disorder associated with lung microbiome dysbiosis. Although the upper airway microbiome is the source of the lung microbiome, the relationships between the oral, nasal, a
Externí odkaz:
https://doaj.org/article/8d4ffefc53a64e1996c162930124d0de
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 204:1117-1119
Autor:
Sanjay H. Chotirmall, Debby Bogaert, James D. Chalmers, Michael J. Cox, Philip M. Hansbro, Yvonne J. Huang, Philip L. Molyneaux, David N. O’Dwyer, Alexa A. Pragman, Geraint B. Rogers, Leopoldo N. Segal, Robert P. Dickson
Publikováno v:
Chotirmall, S H, Bogaert, D, Chalmers, J D, Cox, M J, Hansbro, P M, Huang, Y J, Molyneaux, P L, O'Dwyer, D N, Pragman, A A, Rogers, G B, Segal, L N & Dickson, R P 2022, ' Therapeutic targeting of the respiratory microbiome ', American Journal of Respiratory and Critical Care Medicine, vol. 206, no. 5, pp. 535-544 . https://doi.org/10.1164/rccm.202112-2704PP
The last decade of research has revolutionized our understanding of respiratory microbiology, revealing that the lungs and airways contain diverse and dynamic microbial communities in health and disease. This “respiratory ecosystem”—a densely i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acf3ef56dbbe45683ad2cccb21c3953d
http://hdl.handle.net/10044/1/97388
http://hdl.handle.net/10044/1/97388
Publikováno v:
Seminars in oncology.
Lung cancer is one of the most common and deadly cancers in the world. However, over the last several years, research into lung cancer screening and novel therapeutic approaches have provided promise that earlier detection combined with new treatment
Publikováno v:
BMJ Open
ObjectivesDetermine the effect of twice-daily chlorhexidine oral rinses on oral and lung microbiota biomass and respiratory symptoms.SettingSingle centre.ParticipantsParticipants were aged 40–85 with chronic obstructive pulmonary disease (COPD) and
Autor:
Ken M. Kunisaki, Mariam Siddiqui, Chia Yin Lo, Arianne K Baldomero, Ashley Petersen, John E. Connett, Chris H. Wendt, Alexa A. Pragman
Publikováno v:
International Journal of Chronic Obstructive Pulmonary Disease. 14:881-892
Introduction: Poor oral health has been implicated as an independent risk factor for the development of COPD, but few studies have evaluated the association between oral health and COPD exacerbations. We aimed to determine if poor oral health is asso