Microdialysis on Ex Vivo Porcine Ear Skin Can Validly Study Dermal Penetration including the Fraction of Transfollicular Penetration—Demonstrated on Caffeine Nanocrystals

Autor: Anna Lena Klein, Markus Lubda, David Specht, Sung-Min Pyo, Loris Busch, Jürgen Lademann, Martina C. Meinke, Ingeborg Beckers, Jörg von Hagen, Cornelia M. Keck, Alexa Patzelt

Publikováno v: Nanomaterials, Vol 11, Iss 9, p 2387 (2021)

Common ex vivo methods for penetration investigations often fail to monitor transfollicular penetration appropriately. In the present investigation, the validity of dermal microdialysis on the ex vivo porcine ear skin to investigate penetration kinet

Externí odkaz: https://doaj.org/article/415d0527e81146ebb3ae2872e742e62f

Microneedle-Facilitated Intradermal Proretinal Nanoparticle Delivery

Autor: Benchaphorn Limcharoen, Pattrawadee Toprangkobsin, Marius Kröger, Maxim E. Darvin, Titiporn Sansureerungsikul, Teeranut Rutwaree, Supason Wanichwecharungruang, Wijit Banlunara, Jürgen Lademann, Alexa Patzelt

Publikováno v: Nanomaterials, Vol 10, Iss 2, p 368 (2020)

Topical retinoid treatments stimulate biological activities in the skin. The main physical barrier, which limits the efficacy of transdermal drug delivery, is the stratum corneum. Proretinal nanoparticles (PRN) have already been proven to efficiently

Externí odkaz: https://doaj.org/article/1909918e47aa43c8896de3329f547408

A Dual Fluorescence–Spin Label Probe for Visualization and Quantification of Target Molecules in Tissue by Multiplexed FLIM–EPR Spectroscopy

Autor: Pin Dong, Ernesto Rafael Osorio-Blanco, Amit Kumar, Gregor Nagel, Marcelo Calderón, Lydia M. Bouchet, Christian Teutloff, Alexa Patzelt, Marius Nieke, Monika Schäfer-Korting, Ulrike Alexiev, Silke B. Lohan, Johannes Stellmacher, Martina C. Meinke

Publikováno v: Addi. Archivo Digital para la Docencia y la Investigación
instname
Addi: Archivo Digital para la Docencia y la Investigación
Universidad del País Vasco
Angewandte Chemie (International Ed. in English)

Simultaneous visualization and concentration quantification of molecules in biological tissue is an important though challenging goal. The advantages of fluorescence lifetime imaging microscopy (FLIM) for visualization, and electron paramagnetic reso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c313bc42e085360a32da085f9cb1dfb0
https://doi.org/10.1002/anie.202012852

The impact of skin massage frequency on the intrafollicular transport of silica nanoparticles: Validation of the ratchet effect on an ex vivo porcine skin model

Autor: Alexa Patzelt, Yasemin Keziban, Loris Busch, Martina C. Meinke, Cornelia M. Keck, Jürgen Lademann, Lars Dähne

Publikováno v: European Journal of Pharmaceutics and Biopharmaceutics. 158:266-272

The human hair follicle (HF) represents a promising drug delivery target as an anatomical entity by itself, but also as a gateway enabling dermal or systemic bioavailability of active cosmetic and pharmaceutical ingredients. Due to its morphological

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0324c097efeb9e0116b5af9838d8ea0c
https://doi.org/10.1016/j.ejpb.2020.11.018

Solvent-Containing Closure Material Can Be Used to Prevent Follicular Penetration of Caffeine and Fluorescein Sodium Salt on Porcine Ear Skin

Autor: Ingeborg Beckers, Harald Kolmar, Alexa Patzelt, Paniz Akbarzadeh Taghavi, Markus Lubda, Jürgen Lademann, Jörg von Hagen, Anna Lena Klein

Publikováno v: Skin Pharmacology and Physiology. 33:117-126

Aim: The skin represents a drug delivery portal. The establishment of a skin model capable of distinguishing between the follicular and intercellular penetration pathways remains a challenge. The study described herein was aimed at showing the influe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e0ab64f59eff8b5c11a864b80bdb875
https://doi.org/10.1159/000505839