Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Alex Zomaya"'
Autor:
Richard J. K. Taylor, John Clifford Head, James Thomas Reuberson, Brian Hutchinson, P. Turner, E.C. Boyd, M.A.W. Eaton, B. Hughes, G. Higgs, John Robert Porter, Alex Zomaya, Neil Gozzard, R.A. Allen, Rikki Peter Alexander, Andrew T. Millican, M. Wales, R. Morphy, Joanna Leonard, A. Cannell, Julien Alistair Brown, Martin J. Perry, Byron A. Boyce, Barbara Mason, D. Barnes, Graham John Warrellow
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:1451-1456
The discovery, synthesis and biological activity of a series of triarylethane phosphodiesterase 4 inhibitors is described. Structure-activity relationship studies are presented for CDP840 (29), a potent, chiral, selective inhibitor of PDE 4 (IC(50) 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74d1a5dd3d9373fea6d98706204952b2
https://doi.org/10.1016/s0960-894x(02)00202-0
https://doi.org/10.1016/s0960-894x(02)00202-0
Autor:
Ted A.H. Parton, Alex Zomaya, John Clifford Head, Anthony Shock, Brian Hutchinson, David Critchley, Graham John Warrellow, Julien Alistair Brown, Kirstie Childs, Martyn Kim Robinson, Sarah Catherine Archibald, John Robert Porter
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(12)
The SAR studies to optimise both potency and rate of clearance in the rat for a series of pyrimidine and pyridine based VLA-4 antagonists are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c146f192a183aa92e9b8d40054f1054
https://pubmed.ncbi.nlm.nih.gov/12039570
https://pubmed.ncbi.nlm.nih.gov/12039570
Autor:
Alex Zomaya, John Robert Porter, Ted A.H. Parton, Brian Hutchinson, David Critchley, John Clifford Head, Kirstie Childs, Graham John Warrellow, Anthony Shock, Martyn Kim Robinson, Sarah Catherine Archibald, Julien Alistair Brown
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(12)
SAR studies aimed at improving the rate of clearance of a series of VLA-4 integrin antagonists by the introduction of a 1,3,5-triazine as an amide isostere are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70d99b25a281d7a2443c530160b4b52c
https://pubmed.ncbi.nlm.nih.gov/12039569
https://pubmed.ncbi.nlm.nih.gov/12039569