Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Alex W. Wessel"'
Autor:
Mike Fritz, BS, Daniel Tinker, MD, Alex W. Wessel, BS, Gabriela M. Morris, MD, Linda Goldenberg, MSN, RN, Mark Fesler, MD, Lokesh Rukmangadachar, MD, MS, M. Yadira Hurley, MD
Publikováno v:
JAAD Case Reports, Vol 18, Iss , Pp 99-102 (2021)
Externí odkaz:
https://doaj.org/article/95b200dd8ee34611a1124de92816d52d
Autor:
Younglang Lee, Alex W. Wessel, Jiazhi Xu, Julia G. Reinke, Eries Lee, Somin M. Kim, Amy P. Hsu, Jevgenia Zilberman-Rudenko, Sha Cao, Clinton Enos, Stephen R. Brooks, Zuoming Deng, Bin Lin, Adriana A. de Jesus, Daniel N. Hupalo, Daniela G.P. Piotto, Maria T. Terreri, Victoria R. Dimitriades, Clifton L. Dalgard, Steven M. Holland, Raphaela Goldbach-Mansky, Richard M. Siegel, Eric P. Hanson
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 6 (2022)
Host defense and inflammation are regulated by the NF-κB essential modulator (NEMO), a scaffolding protein with a broad immune cell and tissue expression profile. Hypomorphic mutations in inhibitor of NF-κB kinase regulatory subunit gamma (IKBKG) e
Externí odkaz:
https://doaj.org/article/d9641e906dc34284b7685c0423b10cf5
Autor:
Alex W. Wessel, Nurgun Kose, Robin G. Bombardi, Vicky Roy, Warangkana Chantima, Juthathip Mongkolsapaya, Melissa A. Edeling, Christopher A. Nelson, Irene Bosch, Galit Alter, Gavin R. Screaton, David H. Fremont, James E. Crowe, Michael S. Diamond
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Zika virus is an arthropod-transmitted flavivirus that can cause microcephaly and other fetal abnormalities during pregnancy. Here Wessel et al. develop antibodies against the Zika virus nonstructural protein 1 that protect non-pregnant and pregnant
Externí odkaz:
https://doaj.org/article/bf69c279f51a438a855d5773df6f0873
Autor:
Alex W. Wessel, Michael P. Doyle, Taylor B. Engdahl, Jessica Rodriguez, James E. Crowe, Michael S. Diamond
Publikováno v:
mBio, Vol 12, Iss 5 (2021)
Therapeutic antibodies against flaviviruses often promote neutralization by targeting the envelope protein of the virion. However, this approach is hindered by a possible concern for antibody-dependent enhancement of infection and paradoxical worseni
Externí odkaz:
https://doaj.org/article/452803504505489b8c84cd953cbd6230
Autor:
Christian Shema Mugisha, Hung R. Vuong, Maritza Puray-Chavez, Adam L. Bailey, Julie M. Fox, Rita E. Chen, Alex W. Wessel, Jason M. Scott, Houda H. Harastani, Adrianus C. M. Boon, Haina Shin, Sebla B. Kutluay
Publikováno v:
mSphere, Vol 5, Iss 5 (2020)
ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected millions within just a few months, causing severe respiratory disease and mortality. Assays to monitor SARS-CoV-2 growth in vitro depend on time-consuming and costly R
Externí odkaz:
https://doaj.org/article/5fa8bcf9f0bd472e90df2dc12e6e4f5e
Autor:
Mark Fesler, Linda Goldenberg, Mike Fritz, Daniel Tinker, M. Yadira Hurley, Lokesh A. Rukmangadachar, Alex W. Wessel, Gabriela M. Morris
Publikováno v:
JAAD Case Reports
JAAD Case Reports, Vol 18, Iss, Pp 99-102 (2021)
JAAD Case Reports, Vol 18, Iss, Pp 99-102 (2021)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19c8e5aee5c302276343e6d9637a32c1
http://europepmc.org/articles/PMC8571101
http://europepmc.org/articles/PMC8571101
Autor:
Taylor B. Engdahl, Michael P. Doyle, James E. Crowe, Jessica Rodriguez, Alex W. Wessel, Michael S. Diamond
Publikováno v:
mBio, Vol 12, Iss 5 (2021)
mBio
mBio
Envelope protein-targeted vaccines for flaviviruses are limited by concerns of antibody-dependent enhancement (ADE) of infections. Nonstructural protein 1 (NS1) provides an alternative vaccine target that avoids this risk since this protein is absent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f870c4febdac29a84500a5a55cf009b
https://doi.org/10.1128/mbio.02440-21
https://doi.org/10.1128/mbio.02440-21
Autor:
Robyn S. Klein, Kristen E. Funk, Janet L. Smith, Christina R. DeMaso, Eva Harris, Theodore C. Pierson, Thu Minh Cao, Daved H. Fremont, Kimberly A. Dowd, Melissa A. Edeling, Alex W. Wessel, Christopher A. Nelson, Michael S. Diamond, Ping Zhang, Scott B. Biering, Richard J. Kuhn
Publikováno v:
J Virol
Dengue virus (DENV) and West Nile virus (WNV) are arthropod-transmitted flaviviruses that cause systemic vascular leakage and encephalitis syndromes, respectively, in humans. However, the viral factors contributing to these specific clinical disorder
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f37a0e091b0e907991513bde1bc12a3
https://europepmc.org/articles/PMC8475509/
https://europepmc.org/articles/PMC8475509/
Autor:
George I. Georgiev, Ryan J. Malonis, Ariel S. Wirchnianski, Alex W. Wessel, Helen S. Jung, Sean M. Cahill, Elisabeth K. Nyakatura, Olivia Vergnolle, Kimberly A. Dowd, David Cowburn, Theodore C. Pierson, Michael S. Diamond, Jonathan R. Lai
Publikováno v:
Cell Chem Biol
Zika virus (ZIKV) is a flavivirus that can cause severe disease, but there are no approved treatments or vaccines. A complication for flavivirus vaccine development is the potential of immunogens to enhance infection via antibody-dependent enhancemen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::974ff4d74cb5bb818376d8ddbcee4e36
https://doi.org/10.1016/j.chembiol.2022.02.004
https://doi.org/10.1016/j.chembiol.2022.02.004
Autor:
David H. Fremont, Michael S. Diamond, Gavin R. Screaton, Vicky Roy, Christopher A. Nelson, Juthathip Mongkolsapaya, Robin G. Bombardi, Melissa A. Edeling, Irene Bosch, James E. Crowe, Galit Alter, Nurgun Kose, Warangkana Chantima, Alex W. Wessel
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
There are no licensed therapeutics or vaccines available against Zika virus (ZIKV) to counteract its potential for congenital disease. Antibody-based countermeasures targeting the ZIKV envelope protein have been hampered by concerns for cross-reactiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f92a94c39129f54d34e252f428bbc83d
https://doi.org/10.1038/s41467-020-19096-y
https://doi.org/10.1038/s41467-020-19096-y