Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Alex W Macharia"'
Autor:
D Herbert Opi, Carolyne M Ndila, Sophie Uyoga, Alex W Macharia, Clare Fennell, Lucy B Ochola, Gideon Nyutu, Bethseba R Siddondo, John Ojal, Mohammed Shebe, Kennedy O Awuondo, Neema Mturi, Norbert Peshu, Benjamin Tsofa, Gavin Band, Kathryn Maitland, Dominic P Kwiatkowski, Kirk A Rockett, Thomas N Williams, J Alexandra Rowe
Publikováno v:
PLoS Genetics, Vol 19, Iss 9, p e1010910 (2023)
Blood group O is associated with protection against severe malaria and reduced size and stability of P. falciparum-host red blood cell (RBC) rosettes compared to non-O blood groups. Whether the non-O blood groups encoded by the specific ABO genotypes
Externí odkaz:
https://doaj.org/article/07fa8bb0e3a9466b93188d388f8991ef
Autor:
Sophie Uyoga, PhD, Alex W Macharia, MSc, George Mochamah, MSc, Carolyne M Ndila, PhD, Gideon Nyutu, BSc, Johnstone Makale, BSc, Metrine Tendwa, BSc, Emily Nyatichi, BSc, John Ojal, PhD, Mark Otiende, MSc, Mohammed Shebe, DipMed, Kennedy O Awuondo, BSc, Neema Mturi, MMed, Norbert Peshu, MMed, Benjamin Tsofa, MMed, Kathryn Maitland, ProfFMedSci, J Anthony G Scott, ProfFMedSci, Thomas N Williams, ProfFMedSci
Publikováno v:
The Lancet Global Health, Vol 7, Iss 10, Pp e1458-e1466 (2019)
Summary: Background: Sickle cell disease is the most common severe monogenic disorder in humans. In Africa, 50–90% of children born with sickle cell disease die before they reach their fifth birthday. In this study, we aimed to describe the compara
Externí odkaz:
https://doaj.org/article/f1875ddea719475f8f263dac2dd214fb
Autor:
Sammy Wambua, Tabitha W Mwangi, Moses Kortok, Sophie M Uyoga, Alex W Macharia, Jedidah K Mwacharo, David J Weatherall, Robert W Snow, Kevin Marsh, Thomas N Williams
Publikováno v:
PLoS Medicine, Vol 3, Iss 5, p e158 (2006)
BackgroundThe alpha-thalassaemias are the commonest genetic disorders of humans. It is generally believed that this high frequency reflects selection through a survival advantage against death from malaria; nevertheless, the epidemiological descripti
Externí odkaz:
https://doaj.org/article/a8c6f8bc992443bd84605921228b2e50
Autor:
Reagan M. Mogire, Alireza Morovat, John Muthii Muriuki, Alexander J. Mentzer, Emily L. Webb, Wandia Kimita, Francis M. Ndungu, Alex W. Macharia, Clare L. Cutland, Sodiomon B. Sirima, Amidou Diarra, Alfred B. Tiono, Swaib A. Lule, Shabir A. Madhi, Manjinder S. Sandhu, Andrew M. Prentice, Philip Bejon, John M. Pettifor, Alison M. Elliott, Adebowale Adeyemo, Thomas N. Williams, Sarah H. Atkinson
Publikováno v:
BMC Medicine, Vol 19, Iss 1, Pp 1-14 (2021)
Abstract Background Children living in sub-Saharan Africa have a high burden of rickets and infectious diseases, conditions that are linked to vitamin D deficiency. However, data on the vitamin D status of young African children and its environmental
Externí odkaz:
https://doaj.org/article/af36fc5b4df647808f587d75066738fb
Autor:
Kelvin M. Abuga, John Muthii Muriuki, Sophie M. Uyoga, Kennedy Mwai, Johnstone Makale, Reagan M. Mogire, Alex W. Macharia, Shebe Mohammed, Esther Muthumbi, Salim Mwarumba, Neema Mturi, Philip Bejon, J. Anthony G. Scott, Manfred Nairz, Thomas N. Williams, Sarah H. Atkinson
Publikováno v:
Haematologica, Vol 107, Iss 7 (2021)
Malaria and invasive non-typhoidal Salmonella (NTS) are life-threatening infections that often co-exist in African children. The iron-regulatory hormone hepcidin is highly upregulated during malaria and controls the availability of iron, a critical n
Externí odkaz:
https://doaj.org/article/5f273c88ed874845bcbc4abc14da9594
Autor:
Sophie Uyoga, Alex W. Macharia, Carolyne M. Ndila, Gideon Nyutu, Mohammed Shebe, Kennedy O. Awuondo, Neema Mturi, Norbert Peshu, Benjamin Tsofa, J. Anthony G. Scott, Kathryn Maitland, Thomas N. Williams
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-7 (2019)
Estimates of the burden of malaria often don't take wider, indirect effects on overall health into consideration. Here, Uyoga et al. estimate the indirect impact of malaria on children’s health in a case-control study, using the sickle cell trait a
Externí odkaz:
https://doaj.org/article/7f74bad24cfa4c6e90a9394e67d7980a
Autor:
Alex W. Macharia, Sophie Uyoga, Carolyne Ndila, Gideon Nyutu, Johnstone Makale, Metrine Tendwa, Emily Nyatichi, John Ojal, Sarah Atkinson, Thomas N. Williams
Publikováno v:
Haematologica, Vol 104, Iss 5 (2019)
Externí odkaz:
https://doaj.org/article/c3622a43b118427aa92350e13c026ec5
Autor:
D. Herbert Opi, Carolyne M Ndila, Sophie Uyoga, Alex W Macharia, Clare Fennell, Gideon Nyutu, John Ojal, Mohammed Shebe, Kennedy O Awuondo, Neema Mturi, Norbert Peshu, Benjamin Tsofa, Gavin Band, Kathryn Maitland, Dominic P Kwiatkowski, Kirk A Rockett, Thomas N. Williams, J. Alexandra Rowe
Blood group O is associated with protection against severe malaria and reduced size and stability of P. falciparum-host red blood cell (RBC) rosettes compared to non-O blood groups. Whether the non-O blood groups encoded by the specific ABO genotypes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b109037d29131b9a1e04375551f8732f
https://doi.org/10.1101/2022.08.02.501704
https://doi.org/10.1101/2022.08.02.501704
Autor:
Reagan M. Mogire, John Muthii Muriuki, Alireza Morovat, Alexander J. Mentzer, Emily L. Webb, Wandia Kimita, Francis M. Ndungu, Alex W. Macharia, Clare L. Cutland, Sodiomon B. Sirima, Amidou Diarra, Alfred B. Tiono, Swaib A. Lule, Shabir A. Madhi, Andrew M. Prentice, Philip Bejon, John M. Pettifor, Alison M. Elliott, Adebowale Adeyemo, Thomas N. Williams, Sarah H. Atkinson
Publikováno v:
Nutrients; Volume 14; Issue 7; Pages: 1372
NUTRIENTS
NUTRIENTS
Vitamin D regulates the master iron hormone hepcidin, and iron in turn alters vitamin D metabolism. Although vitamin D and iron deficiency are highly prevalent globally, little is known about their interactions in Africa. To evaluate associations bet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47d2f577aab8b665eb00829b8f5295d1
https://pubmed.ncbi.nlm.nih.gov/35405984
https://pubmed.ncbi.nlm.nih.gov/35405984
Autor:
Alex W, Macharia, Sophie, Uyoga, Carolyne, Ndila, Gideon, Nyutu, Johnstone, Makale, Metrine, Tendwa, Emily, Nyatichi, John, Ojal, Sarah, Atkinson, Thomas N, Williams
Publikováno v:
Haematologica. 104(5)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::02d9ecb544fbca0ea5d8eb8af41e1354
https://pubmed.ncbi.nlm.nih.gov/30467202
https://pubmed.ncbi.nlm.nih.gov/30467202