Zobrazeno 1 - 10
of 493
pro vyhledávání: '"Alex W Hewitt"'
Autor:
Jenna Hall, Maciej Daniszewski, Shane Cheung, Kalyan Shobhana, Himeesh Kumar, Helena H Liang, Henry Beetham, Ellie Cho, Carla Abbott, Alex W Hewitt, Kaylene J Simpson, Robyn H Guymer, Daniel Paull, Alice Pébay, Grace E. Lidgerwood
Publikováno v:
SLAS Technology, Vol 29, Iss 3, Pp 100106- (2024)
Age-Related Macular Degeneration (AMD) is a highly prevalent form of retinal disease amongst Western communities over 50 years of age. A hallmark of AMD pathogenesis is the accumulation of drusen underneath the retinal pigment epithelium (RPE), a bio
Externí odkaz:
https://doaj.org/article/4a7f9281b8ca4b939616a31e76f62cde
Autor:
Rajya L Gurung, Liesel M FitzGerald, Ebony Liu, Bennet J McComish, Georgia Kaidonis, Bronwyn Ridge, Alex W Hewitt, Brendan J Vote, Nitin Verma, Jamie E Craig, Kathryn P Burdon
Publikováno v:
International Journal of Retina and Vitreous, Vol 9, Iss 1, Pp 1-10 (2023)
Abstract Background Intravitreal anti-vascular endothelial growth factor (anti-VEGF) injections are the standard of care for diabetic macular edema (DME), a common complication of diabetes. This study aimed to identify factors influencing DME intravi
Externí odkaz:
https://doaj.org/article/c30b9b2eaa33494fbc814d635db0810a
Autor:
David A Mackey, Alex W Hewitt, Stuart MacGregor, Puya Gharahkhani, Jamie E Craig, Mathias Seviiri, Jue-Sheng Ong, Matthew H Law, Weixiong He, Santiago Diaz Torres, Yeda Wu, Nathan Ingold, Regina Yu
Publikováno v:
BMJ Open, Vol 13, Iss 8 (2023)
Purpose Glaucoma, a major cause of irreversible blindness, is a highly heritable human disease. Currently, the majority of the risk genes for glaucoma are unknown. We established the Genetics of Glaucoma Study (GOGS) to identify disease genes and imp
Externí odkaz:
https://doaj.org/article/ec0ac3aa056d4f10b8819f1d48fdb264
Autor:
Hannah Currant, Pirro Hysi, Tomas W Fitzgerald, Puya Gharahkhani, Pieter W M Bonnemaijer, Anne Senabouth, Alex W Hewitt, UK Biobank Eye and Vision Consortium, International Glaucoma Genetics Consortium, Denize Atan, Tin Aung, Jason Charng, Hélène Choquet, Jamie Craig, Peng T Khaw, Caroline C W Klaver, Michiaki Kubo, Jue-Sheng Ong, Louis R Pasquale, Charles A Reisman, Maciej Daniszewski, Joseph E Powell, Alice Pébay, Mark J Simcoe, Alberta A H J Thiadens, Cornelia M van Duijn, Seyhan Yazar, Eric Jorgenson, Stuart MacGregor, Chris J Hammond, David A Mackey, Janey L Wiggs, Paul J Foster, Praveen J Patel, Ewan Birney, Anthony P Khawaja
Publikováno v:
PLoS Genetics, Vol 17, Iss 10, p e1009858 (2021)
[This corrects the article DOI: 10.1371/journal.pgen.1009497.].
Externí odkaz:
https://doaj.org/article/338b1c0619514cbe850079612498448a
Autor:
Fred K Chen, Alex W Hewitt, Alan Ma, John Grigg, Keith R Martin, Robyn Jamieson, Heather G Mack, Fleur O’Hare, David Mackey, John De Roach, Alexis Ceecee Britten-Jones, Myra McGuinness, Nicole Tindill, Lauren Ayton, Anai Gonzalez Cordero, Thomas L Edwards, Gladys Ho, Michael Hogden, Anthony Kwan, Tina Lamey, Terri McLaren, Benjamin Nash, Jon Ruddle, Matthew Simunovic, Ingrid Sinnerbrink, Deepa Ajay Taranath, Jen Thompson, Jaclyn White
Publikováno v:
BMJ Open, Vol 11, Iss 6 (2021)
Introduction Voretigene neparvovec-rzyl (Luxturna) was approved by the Australian Therapeutic Goods Administration on 4 August 2020 for the treatment of biallelic mutations in the RPE65 gene, a rare cause of congenital and adult-onset retinal dystrop
Externí odkaz:
https://doaj.org/article/748c300353da46cfad1dfa7d7e12385a
Autor:
Hannah Currant, Pirro Hysi, Tomas W Fitzgerald, Puya Gharahkhani, Pieter W M Bonnemaijer, Anne Senabouth, Alex W Hewitt, UK Biobank Eye and Vision Consortium, International Glaucoma Genetics Consortium, Denize Atan, Tin Aung, Jason Charng, Hélène Choquet, Jamie Craig, Peng T Khaw, Caroline C W Klaver, Michiaki Kubo, Jue-Sheng Ong, Louis R Pasquale, Charles A Reisman, Maciej Daniszewski, Joseph E Powell, Alice Pébay, Mark J Simcoe, Alberta A H J Thiadens, Cornelia M van Duijn, Seyhan Yazar, Eric Jorgenson, Stuart MacGregor, Chris J Hammond, David A Mackey, Janey L Wiggs, Paul J Foster, Praveen J Patel, Ewan Birney, Anthony P Khawaja
Publikováno v:
PLoS Genetics, Vol 17, Iss 5, p e1009497 (2021)
Optical Coherence Tomography (OCT) enables non-invasive imaging of the retina and is used to diagnose and manage ophthalmic diseases including glaucoma. We present the first large-scale genome-wide association study of inner retinal morphology using
Externí odkaz:
https://doaj.org/article/4fbf3860d58c43b3bbd68818f972b31d
Autor:
Wissam Chiha, Chrisna J LeVaillant, Carole A Bartlett, Alex W Hewitt, Phillip E Melton, Melinda Fitzgerald, Alan R Harvey
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0192348 (2018)
Partial transection (PT) of the optic nerve is an established experimental model of secondary degeneration in the central nervous system. After a dorsal transection, retinal ganglion cells (RGCs) with axons in ventral optic nerve are intact but vulne
Externí odkaz:
https://doaj.org/article/d7ed955f0acd46cc9e5fcb5a1eebd7e0
Autor:
Abraham Kuot, Alex W Hewitt, Grant R Snibson, Emmanuelle Souzeau, Richard Mills, Jamie E Craig, Kathryn P Burdon, Shiwani Sharma
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0183719 (2017)
Fuchs' endothelial corneal dystrophy (FECD) is a progressive, vision impairing disease. Common single nucleotide polymorphisms (SNPs) and a trinucleotide repeat polymorphism, thymine-guanine-cytosine (TGC), in the TCF4 gene have been associated with
Externí odkaz:
https://doaj.org/article/3f25a806caa345e590335d658fae7e20
Autor:
Tiger Zhou, Emmanuelle Souzeau, Shiwani Sharma, John Landers, Richard Mills, Ivan Goldberg, Paul R Healey, Stuart Graham, Alex W Hewitt, David A Mackey, Anna Galanopoulos, Robert J Casson, Jonathan B Ruddle, Jonathan Ellis, Paul Leo, Matthew A Brown, Stuart MacGregor, David J Lynn, Kathryn P Burdon, Jamie E Craig
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0172427 (2017)
PURPOSE:To identify biological processes associated with POAG and its subtypes, high-tension (HTG) and normal-tension glaucoma (NTG), by analyzing rare potentially damaging genetic variants. METHODS:A total of 122 and 65 unrelated HTG and NTG partici
Externí odkaz:
https://doaj.org/article/2afdebc80a9b4a408114345178205702
Autor:
Nicole J Van Bergen, Jonathan G Crowston, Jamie E Craig, Kathryn P Burdon, Lisa S Kearns, Shiwani Sharma, Alex W Hewitt, David A Mackey, Ian A Trounce
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140919 (2015)
Primary Open Angle Glaucoma (POAG) is a common neurodegenerative disease characterized by the selective and gradual loss of retinal ganglion cells (RGCs). Aging and increased intraocular pressure (IOP) are glaucoma risk factors; nevertheless patients
Externí odkaz:
https://doaj.org/article/85611cb6ab6742079f21386c3150103f