Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Alex U. Singer"'
Autor:
Gregory D. Martyn, Gianluca Veggiani, Ulrike Kusebauch, Seamus R. Morrone, Bradley P. Yates, Alex U. Singer, Jiefei Tong, Noah Manczyk, Gerald Gish, Zhi Sun, Igor Kurinov, Frank Sicheri, Michael F. Moran, Robert L. Moritz, Sachdev S. Sidhu
Publikováno v:
ACS Chem Biol
A comprehensive analysis of the phosphoproteome is essential for understanding molecular mechanisms of human diseases. However, current tools used to enrich phosphotyrosine (pTyr) are limited in their applicability and scope. Here, we engineered new
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da7b589c2dcc874e1febc7789a5a028c
https://doi.org/10.1021/acschembio.2c00051
https://doi.org/10.1021/acschembio.2c00051
Publikováno v:
Journal of molecular biology. 433(24)
Domains found in ubiquitin specific proteases (DUSPs) occur in seven members of the ubiquitin specific protease (USP) family. DUSPs are defined by a distinct structural fold but their functions remain largely unknown, although studies with USP4 sugge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b6d43529bcca443067664c22727f8ba
https://pubmed.ncbi.nlm.nih.gov/34666042
https://pubmed.ncbi.nlm.nih.gov/34666042
Autor:
Darrell Desveaux, Alex U Singer, Ai-Jiuan Wu, Brian C McNulty, Laura Musslewhite, Zachary Nimchuk, John Sondek, Jeffrey L Dangl
Publikováno v:
PLoS Pathogens, Vol 3, Iss 6 (2007)
Externí odkaz:
https://doaj.org/article/d936e672624441a8a177d775591b736f
Autor:
Darrell Desveaux, Alex U Singer, Ai-Jiuan Wu, Brian C McNulty, Laura Musselwhite, Zachary Nimchuk, John Sondek, Jeffery L Dangl
Publikováno v:
PLoS Pathogens, Vol 3, Iss 3, p e48 (2007)
The Pseudomonas syringae type III effector protein avirulence protein B (AvrB) is delivered into plant cells, where it targets the Arabidopsis RIN4 protein (resistance to Pseudomonas maculicula protein 1 [RPM1]-interacting protein). RIN4 is a regulat
Externí odkaz:
https://doaj.org/article/3040bbbd5c7e475ab27054da2efcaa25
Publikováno v:
Protein Sci
To understand the molecular evolution of functional diversity in protein families, we comprehensively investigated the consequences of all possible mutation combinations separating two peptide-binding domains with highly divergent specificities. We a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3600fa2600851135c4a981e6ca7452e
https://pubmed.ncbi.nlm.nih.gov/31654425
https://pubmed.ncbi.nlm.nih.gov/31654425
Autor:
Joseph S. Brunzelle, George Minasov, Alexander F. Yakunin, Wayne F. Anderson, Greg Brown, Elena Evdokimova, Taeho Kim, Alex U. Singer, Robert Flick, Radhakrishnan Mahadevan, Jeong Chan Joo, Alexei Savchenko
The nonnatural alcohol 1,3-butanediol (1,3-BDO) is a valuable building block for the synthesis of various polymers. One of the potential pathways for the biosynthesis of 1,3-BDO includes the biotransformation of acetaldehyde to 1,3-BDO via 3-hydroxyb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a883351f7499971144d3db2023fba27a
https://europepmc.org/articles/PMC5359500/
https://europepmc.org/articles/PMC5359500/
Autor:
Jason Moffat, Frank W. Schmitges, Bradley B. Brasher, Carsten Schwerdtfeger, Patrick Jaynes, Michael F. Moran, Pieter Johan Adam Eichhorn, Alex U. Singer, Joan Teyra, G. Boehmelt, M.J. Polyak, Philippe Gros, J. Tong, Derek F. Ceccarelli, Nassima Fodil, Jonathan R. Krieger, S. Kit Leng Lui, M. Lenter, Frank Sicheri, Sachdev S. Sidhu
Publikováno v:
Structure. 27:590-605.e5
Summary The multi-domain deubiquitinase USP15 regulates diverse eukaryotic processes and has been implicated in numerous diseases. We developed ubiquitin variants (UbVs) that targeted either the catalytic domain or each of three adaptor domains in US
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52ddfc72123ce2ba59eddfc3aef310f0
https://doi.org/10.1016/j.str.2019.01.002
https://doi.org/10.1016/j.str.2019.01.002
Autor:
Olga Egorova, Alex U. Singer, Alexander F. Yakunin, Anatoli Tchigvintsev, Tatyana N. Chernikova, Peter N. Golyshin, Elena Evdokimova, Michail M. Yakimov, Greg Brown, Sofia Lemak, Alexei Savchenko, Claudio F. Gonzalez, Richard Reinhardt, Robert Flick, Pierre Petit, Michael Kube
Publikováno v:
Biochemical Journal. 445:193-203
The uncharacterized α/β-hydrolase protein OLEI01171 from the psychrophilic marine bacterium Oleispira antarctica belongs to the PF00756 family of putative esterases, which also includes human esterase D. In the present paper we show that purified r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc5efc25756a1b0848866821a5179923
https://doi.org/10.1042/bj20112113
https://doi.org/10.1042/bj20112113
Autor:
Claudio F. Gonzalez, Elena Evdokimova, Kemin Tan, Alexei Savchenko, Alexander F. Yakunin, Greg Brown, Alex U. Singer, Robert Flick, Anatoli Tchigvintsev
Publikováno v:
Journal of Biological Chemistry. 287:1874-1883
The β-hydroxyacid dehydrogenases form a large family of ubiquitous enzymes that catalyze oxidation of various β-hydroxy acid substrates to corresponding semialdehydes. Several known enzymes include β-hydroxyisobutyrate dehydrogenase, 6-phosphogluc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::016977f21915f59a4e4c062c379afaf8
https://doi.org/10.1074/jbc.m111.294561
https://doi.org/10.1074/jbc.m111.294561
Autor:
Aiping Dong, Alex U. Singer, Eugene Melamud, Alexei Savchenko, Xiaohui Xu, Hong Cui, Michelle F. Clasquin, Amy A. Caudy, Jessica R Gooding, Alexander F. Yakunin, Joshua D. Rabinowitz, Shawn R. Campagna
Publikováno v:
Cell. 145:969-980
SummaryGlucose is catabolized in yeast via two fundamental routes, glycolysis and the oxidative pentose phosphate pathway, which produces NADPH and the essential nucleotide component ribose-5-phosphate. Here, we describe riboneogenesis, a thermodynam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::661e0be54a9531ea849f1976618e256f
https://doi.org/10.1016/j.cell.2011.05.022
https://doi.org/10.1016/j.cell.2011.05.022