Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Alex Toftgaard Nielsen"'
Autor:
Yixin Rong, Adrian Frey, Emre Özdemir, Arrate Sainz de la Maza Larrea, Songyuan Li, Alex Toftgaard Nielsen, Sheila Ingemann Jensen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-8 (2024)
Abstract Replacing petrochemicals with compounds from bio-based manufacturing processes remains an important part of the global effort to move towards a sustainable future. However, achieving economic viability requires both optimized cell factories
Externí odkaz:
https://doaj.org/article/c8a5ae49da244125aa8268310c934d03
Autor:
Philip J. Gorter de Vries, Viviënne Mol, Nikolaus Sonnenschein, Torbjørn Ølshøj Jensen, Alex Toftgaard Nielsen
Publikováno v:
Microbial Biotechnology, Vol 17, Iss 2, Pp n/a-n/a (2024)
Abstract Acetogenic gas fermentation is increasingly studied as a promising technology to upcycle carbon‐rich waste gasses. Currently the product range is limited, and production yields, rates and titres for a number of interesting products do not
Externí odkaz:
https://doaj.org/article/e743d2a0cfba4ab6ae45450d2295cfb6
Autor:
Marie Millgaard, Gonzalo Nahuel Bidart, Ivan Pogrebnyakov, Alex Toftgaard Nielsen, Ditte Hededam Welner
Publikováno v:
AMB Express, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Parageobacillus thermoglucosidasius is a thermophilic Gram-positive bacterium, which is a promising host organism for sustainable bio-based production processes. However, to take full advantage of the potential of P. thermoglucosidasius, mor
Externí odkaz:
https://doaj.org/article/1bf9e2a1233c4aac83f9a0d8c3579824
Publikováno v:
Microbial Biotechnology, Vol 15, Iss 9, Pp 2426-2438 (2022)
Summary Randomized strain and pathway engineering are critical to improving microbial cell factory performance, calling for the development of high‐throughput screening and selection systems. To facilitate this effort, we have developed two 96‐we
Externí odkaz:
https://doaj.org/article/2136c7bbe2b0494e8c786b7a6de19e97
Autor:
Ariane Zutz, Louise Hamborg, Lasse Ebdrup Pedersen, Maher M. Kassem, Elena Papaleo, Anna Koza, Markus J. Herrgård, Sheila Ingemann Jensen, Kaare Teilum, Kresten Lindorff-Larsen, Alex Toftgaard Nielsen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Heterologous expression of recombinant proteins often results in misfolding, aggregation and degradation. Here, we show an in vivo dual-biosensor system that simultaneously assesses protein translation and protein folding, thereby enabling rapid scre
Externí odkaz:
https://doaj.org/article/d73636bd2c4c476f86d904abfec19668
Autor:
Louise Hamborg, Daniele Granata, Johan G. Olsen, Jennifer Virginia Roche, Lasse Ebdrup Pedersen, Alex Toftgaard Nielsen, Kresten Lindorff-Larsen, Kaare Teilum
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
Louise Hamborg et al. use a cell-based screen in E. coli to look for mutants of chymotrypsin inhibitor 2 which are either destabilized or stabilized, in an effort to identify a larger library of mutants which might improve stability prediction. Their
Externí odkaz:
https://doaj.org/article/e62f07713f7946109276026a00012c4c
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Toxicity and limited solubility inhibits the biological production of many organic compounds. Here the authors metabolically engineer sulfate uptake and activation in order to produce sulfate esters of phenolic compounds, such as zosteric acid, there
Externí odkaz:
https://doaj.org/article/4d40893c73e04afca88245dc6f05483d
Autor:
Torbjørn Ølshøj Jensen, Christian Tellgren-Roth, Stephanie Redl, Jérôme Maury, Simo Abdessamad Baallal Jacobsen, Lasse Ebdrup Pedersen, Alex Toftgaard Nielsen
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Single molecule real-time DNA sequencing allows genome-wide identification of DNA methylation patterns. Here, Jensen et al. present a high-throughput method that allows rapid coupling of DNA methylation patterns with their corresponding methyltransfe
Externí odkaz:
https://doaj.org/article/a17958eda3f1464098a0d1f520c422e1
Autor:
Elsayed T. Mohamed, Hemanshu Mundhada, Jenny Landberg, Isaac Cann, Roderick I. Mackie, Alex Toftgaard Nielsen, Markus J. Herrgård, Adam M. Feist
Publikováno v:
Microbial Cell Factories, Vol 18, Iss 1, Pp 1-14 (2019)
Abstract Background Sucrose is an attractive industrial carbon source due to its abundance and the fact that it can be cheaply generated from sources such as sugarcane. However, only a few characterized Escherichia coli strains are able to metabolize
Externí odkaz:
https://doaj.org/article/92080b068647443d8ff65a381a6ac2f0
Autor:
Torbjørn Ølshøj Jensen, Ivan Pogrebnyakov, Kristoffer Bach Falkenberg, Stephanie Redl, Alex Toftgaard Nielsen
Publikováno v:
AMB Express, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Use of thermophilic organisms has a range of advantages, but the significant lack of engineering tools limits their applications. Here we show that β-galactosidase from Geobacillus stearothermophilus (BgaB) can be applicable in a range of c
Externí odkaz:
https://doaj.org/article/10bc41fb89f340ed86c85fbb83496db2