Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Alex Straiker"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Many species use chemical messengers to communicate a remarkable range of information. Mice appear to make particular use of chemical messengers, including effects on estrous cycling and initiation, pregnancy, aggression, stress and of cours
Externí odkaz:
https://doaj.org/article/a6a2e281001a43dba955852b5809fd75
Autor:
Natalia Murataeva, Sam Mattox, Josh Lemieux, John Griffis, Kyle Yust, Wenwen Du, Thomas Heinbockel, Alex Straiker
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Salivation is easily taken for granted, but without normal salivation, simple essential tasks such as chewing and swallowing become difficult, with consequences for quality of life, nutrition and oral health. Many important drug classes caus
Externí odkaz:
https://doaj.org/article/9f609a6577834293b7bdd3e0da492598
Publikováno v:
Drugs and Drug Candidates, Vol 2, Iss 3, Pp 689-707 (2023)
The endocannabinoid system is found throughout the CNS and the body where it impacts many important physiological processes. Expectations were high that targeting cannabinoid receptors would prove therapeutically beneficial; pharmaceutical companies
Externí odkaz:
https://doaj.org/article/b24896ad42f04037b517e1c5b3529802
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Autaptic hippocampal neurons are an architecturally simple model of neurotransmission that express several forms of cannabinoid signaling. Over the past twenty years this model has proven valuable for studies ranging from enzymatic control o
Externí odkaz:
https://doaj.org/article/2380e0c857834d04a1b5d92f15368679
Autor:
Audrey Flavin, Paniz Azizi, Natalia Murataeva, Kyle Yust, Wenwen Du, Ruth Ross, Iain Greig, Thuy Nguyen, Yanan Zhang, Ken Mackie, Alex Straiker
Publikováno v:
Molecules, Vol 29, Iss 8, p 1881 (2024)
While the opioid crisis has justifiably occupied news headlines, emergency rooms are seeing many thousands of visits for another cause: cannabinoid toxicity. This is partly due to the spread of cheap and extremely potent synthetic cannabinoids that c
Externí odkaz:
https://doaj.org/article/54a9a8ab5fc1420d99b822d2986bffd9
Autor:
Kelsey Andreis, Jenna Billingsley, Kian Naimi Shirazi, Jim Wager-Miller, Clare Johnson, Heather Bradshaw, Alex Straiker
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Saliva serves multiple important functions within the body that we typically take for granted, such as helping prepare food for swallowing and defense against oral pathogens. Dry mouth is a primary symptom of Sjӧgren’s syndrome and is a s
Externí odkaz:
https://doaj.org/article/acef610bca5b424f8eedf297ee590050
Autor:
Michaela Dvorakova, Sierra Wilson, Wesley Corey, Jenna Billingsley, Anaëlle Zimmowitch, Joye Tracey, Alex Straiker, Ken Mackie
Publikováno v:
Molecules, Vol 27, Iss 17, p 5655 (2022)
In addition to phytocannabinoids, cannabis contains terpenoids that are claimed to have a myriad of effects on the body. We tested a panel of five common cannabis terpenoids, myrcene, linalool, limonene, α-pinene and nerolidol, in two neuronal model
Externí odkaz:
https://doaj.org/article/cbc93cc155334f55b3eafed0620fccf4
Autor:
Thomas Heinbockel, Alex Straiker
Publikováno v:
Frontiers in Neural Circuits, Vol 15 (2021)
Our sensory systems such as the olfactory and visual systems are the target of neuromodulatory regulation. This neuromodulation starts at the level of sensory receptors and extends into cortical processing. A relatively new group of neuromodulators i
Externí odkaz:
https://doaj.org/article/f3f3ec0ed82546fd820e781e33dce3cb
Autor:
Alex Straiker, Sierra Wilson, Wesley Corey, Michaela Dvorakova, Taryn Bosquez, Joye Tracey, Caroline Wilkowski, Kathleen Ho, Jim Wager-Miller, Ken Mackie
Publikováno v:
Molecules, Vol 26, Iss 17, p 5352 (2021)
Cannabis contains more than 100 phytocannabinoids. Most of these remain poorly characterized, particularly in neurons. We tested a panel of five phytocannabinoids—cannabichromene (CBC), cannabidiolic acid (CBDA), cannabidivarin (CBDV), cannabidivar
Externí odkaz:
https://doaj.org/article/9377fa9a7c33480abfb38c3cdb1db5e3
Publikováno v:
Neurobiology of Disease, Vol 56, Iss , Pp 1-5 (2013)
Fragile X Syndrome (FXS) is a heritable form of mental retardation caused by a non-coding trinucleotide expansion of the FMR1 gene leading to loss of expression of this RNA binding protein. Mutations in this gene are strongly linked to enhanced Group
Externí odkaz:
https://doaj.org/article/6096e21997e847f7b2097a63c2acfc12