Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Alex Stowell"'
Autor:
Amanda J. Watson, Gemma V. Hopkins, Samantha Hitchin, Habiba Begum, Stuart Jones, Allan Jordan, Sarah Holt, H. Nikki March, Rebecca Newton, Helen Small, Alex Stowell, Ian D. Waddell, Bohdan Waszkowycz, Donald J. Ogilvie
Publikováno v:
F1000Research, Vol 5 (2016)
RET (REarranged during Transfection) is a receptor tyrosine kinase, which plays pivotal roles in regulating cell survival, differentiation, proliferation, migration and chemotaxis. Activation of RET is a mechanism of oncogenesis in medullary thyroid
Externí odkaz:
https://doaj.org/article/96b9e34465224e6ea3077ebb933196a0
Autor:
Amanda J. Watson, Gemma V. Hopkins, Samantha Hitchin, Habiba Begum, Stuart Jones, Allan Jordan, Sarah Holt, H. Nikki March, Rebecca Newton, Helen Small, Alex Stowell, Ian D. Waddell, Bohdan Waszkowycz, Donald J. Ogilvie
Publikováno v:
F1000Research, Vol 5 (2016)
RET (REarranged during Transfection) is a receptor tyrosine kinase, which plays pivotal roles in regulating cell survival, differentiation, proliferation, migration and chemotaxis. Activation of RET is a mechanism of oncogenesis in medullary thyroid
Externí odkaz:
https://doaj.org/article/129cb938044645b4be8abc534fed27f3
Autor:
Colin Hutton, Mark W. Richards, Chitra Seewooruthun, Stuart Donald Jones, Samantha Hitchin, Daniel Burschowsky, Allan M. Jordan, Richard Bayliss, Li-Ying Lin, Alex Stowell, Bohdan Waszkowycz, Aude Echalier, Shaun Johns, Mandy Watson, Donald J. Ogilvie, Habiba Begum, Ian D. Waddell, Rebecca Newton
Publikováno v:
Cancer Research. 77:3236-3236
Activating gene fusions in the RET receptor tyrosine kinase have been found to drive 1-2% of lung adenocarcinomas and therefore offer an attractive target for targeted therapy. Whilst non-selective tyrosine kinase inhibitors with RET activity are eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1069c1ee3bce7aac8ea057c4b10c9d66
https://doi.org/10.1158/1538-7445.am2017-3236
https://doi.org/10.1158/1538-7445.am2017-3236
Autor:
Stuart Donald Jones, Alan Lau, Nicola Hamilton, Ian D. Waddell, Katherine Clegg Smith, Bohdan Waszkowycz, Alison MGonagle, Julie A. Tucker, Steven Durant, Mark J. O'Connor, Donald J. Ogilvie, Alex Stowell, Dominic I. James, Allan M. Jordan, Cliff Jones
Publikováno v:
Cancer Research. 76:4352-4352
DNA repair is a critical process for the survival and normal proliferation of healthy cells. However, given the enhanced levels of cellular stress and genomic instability, these repair processes are even more critical to the survival of malignant cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e24b31c94b30b7f2f964ad242f99d14
https://doi.org/10.1158/1538-7445.am2016-4352
https://doi.org/10.1158/1538-7445.am2016-4352
Autor:
Stuart Donald Jones, James R. Hitchin, Julie A. Tucker, Donald J. Ogilvie, Alison E. McGonagle, Helen F. Small, Cliff Jones, Katherine Clegg Smith, Ben Acton, Bohdan Waszkowycz, Colin Hutton, Allan M. Jordan, Ian D. Waddell, Alex Stowell, Dominic I. James, Nicola Hamilton
Publikováno v:
Cancer Research. 76:3715-3715
In recent years, many proteins involved in DNA repair, such as ATR, ATM and PARP, have received considerable attention as potential points of therapeutic intervention in cancer. Indeed, these efforts have recently delivered several agents into clinic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a369d40a7b7c358c70282e25c732f04e
https://doi.org/10.1158/1538-7445.am2016-3715
https://doi.org/10.1158/1538-7445.am2016-3715
Autor:
Nicola Hamilton, Stuart Donald Jones, Ben Acton, Bohdan Waszkowycz, Helen F. Small, Katherine Clegg Smith, Allan M. Jordan, Daniel P. Mould, Julie A. Tucker, Donald J. Ogilvie, Ian D. Waddell, Dominic I. James, Alex Stowell, Alison E. McGonagle, Cliff Jones
Publikováno v:
Cancer Research. 76:3714-3714
The macrodomain protein poly(ADP ribose) glycohydrolase (PARG) has been shown to be a critical component in the repair of single stand DNA breaks and counteracts the function of the ARTD family of poly(ADP ribose) polymerases, commonly known as the P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::189433740f0d1df0d075fea4683860ac
https://doi.org/10.1158/1538-7445.am2016-3714
https://doi.org/10.1158/1538-7445.am2016-3714
Autor:
Sarah Holt, Ben Acton, Katherine Clegg Smith, Alison E. McGonagle, Bohdan Waszkowycz, Dominic I. James, Ian D. Waddell, James Hitchen, Niall M. Hamilton, Helen F. Small, Donald J. Ogilvie, Allan M. Jordan, Colin Huttom, Emma E. Fairweather, Alex Stowell, Nicola Hamilton
Publikováno v:
Cancer Research. 75:3656-3656
Background: DNA single strand breaks (SSBs) are the most common type of damage occurring in cells. Poly (ADP ribose) polymerase (PARP) binds to SSBs and auto-ribosylates itself using NAD+ as a substrate. PARG is the only enzyme known to efficiently c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::052a37cd6af34cffec8364d9f5556f70
https://doi.org/10.1158/1538-7445.am2015-3656
https://doi.org/10.1158/1538-7445.am2015-3656
Autor:
James R. Hitchin, Ian D. Waddell, Julian Blagg, Samantha Burns, Niall M. Hamilton, Allan M. Jordan, Emma E. Fairweather, Graeme J. Thomson, Daniel P. Mould, Rosemary Burke, Mark Cockerill, Alex Stowell, Donald J. Ogilvie, Colin Hutton
Publikováno v:
Molecular Cancer Therapeutics. 12:B98-B98
There is currently considerable interest in lysine-specific histone demethylase 1 (LSD1) as a therapeutic target in human malignancies. Specifically LSD1 has been demonstrated to be an essential regulator of leukaemia stem cell potential, inhibiting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::693d000c721c8403d5f9faf2d5edf63a
https://doi.org/10.1158/1535-7163.targ-13-b98
https://doi.org/10.1158/1535-7163.targ-13-b98