Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Alex Steimle"'
Autor:
Joana Gaifem, Ana Mendes-Frias, Mathis Wolter, Alex Steimle, Maria Jose Garzón, Carles Ubeda, Clarisse Nobre, Abigail González, Salomé S. Pinho, Cristina Cunha, Agostinho Carvalho, António Gil Castro, Mahesh S. Desai, Fernando Rodrigues, Ricardo Silvestre
Publikováno v:
mBio, Vol 15, Iss 4 (2024)
ABSTRACTInflammatory bowel disease (IBD) is a group of inflammatory conditions of the gastrointestinal tract. The etiology of IBD remains elusive, but the disease is suggested to arise from the interaction of environmental and genetic factors that tr
Externí odkaz:
https://doaj.org/article/901d2df1c4f24487808e4756a780fae5
Publikováno v:
mSystems, Vol 6, Iss 6 (2021)
ABSTRACT Food safety has considerably improved worldwide, yet infections with foodborne human enteric pathogens, such as Listeria spp. and Salmonella spp., still cause numerous hospitalizations and fatalities. Since dietary alterations, including fib
Externí odkaz:
https://doaj.org/article/42f41da632944588abb2ddc253ae7778
Autor:
Alex Steimle, Alessandro De Sciscio, Mareike Neumann, Erica T. Grant, Gabriel V. Pereira, Hiroshi Ohno, Eric C. Martens, Mahesh S. Desai
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100607- (2021)
Summary: Reproducible in vivo models are necessary to address functional aspects of the gut microbiome in various diseases. Here, we present a gnotobiotic mouse model that allows for the investigation of specific microbial functions within the microb
Externí odkaz:
https://doaj.org/article/faee353c464c4ed4ad015b89830f2e5b
Publikováno v:
STAR Protocols, Vol 2, Iss 1, Pp 100326- (2021)
Summary: The gut microbiome expresses a multitude of enzymes degrading polysaccharides in dietary plant fibers and in host-secreted mucus. The quantitative detection of these glycan-degrading enzymes in fecal samples is important to elucidate the fun
Externí odkaz:
https://doaj.org/article/d0e012e970f44cf9a125e145b17fb9d7
Autor:
Lena Michaelis, Marcel Treß, Hanna-Christine Löw, Johanna Klees, Christian Klameth, Anna Lange, Anne Grießhammer, Andrea Schäfer, Sarah Menz, Alex Steimle, Klaus Schulze-Osthoff, Julia-Stefanie Frick
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Intestinal commensal bacteria can have a large impact on the state of health and disease of the host. Regulation of Th17 cell development by gut commensals is known to contribute to their dichotomous role in promoting gut homeostasis and host defense
Externí odkaz:
https://doaj.org/article/c90f1f279499411ab3036a2fab15e1a2
Autor:
Mareike Neumann, Alex Steimle, Erica T. Grant, Mathis Wolter, Amy Parrish, Stéphanie Willieme, Dirk Brenner, Eric C. Martens, Mahesh S. Desai
Publikováno v:
Gut Microbes, Vol 13, Iss 1 (2021)
The change of dietary habits in Western societies, including reduced consumption of fiber, is linked to alterations in gut microbial ecology. Nevertheless, mechanistic connections between diet-induced microbiota changes that affect colonization resis
Externí odkaz:
https://doaj.org/article/533332f5f3bf4e4495a6be7d56804884
Autor:
Alex Steimle, Sarah Menz, Annika Bender, Brianna Ball, Alexander N R Weber, Thomas Hagemann, Anna Lange, Jan K Maerz, Raphael Parusel, Lena Michaelis, Andrea Schäfer, Hans Yao, Hanna-Christine Löw, Sina Beier, Mehari Tesfazgi Mebrhatu, Kerstin Gronbach, Samuel Wagner, David Voehringer, Martin Schaller, Birgit Fehrenbacher, Ingo B Autenrieth, Tobias A Oelschlaeger, Julia-Stefanie Frick
Publikováno v:
PLoS Biology, Vol 17, Iss 6, p e3000334 (2019)
Escherichia coli represents a classical intestinal gram-negative commensal. Despite this commensalism, different E. coli strains can mediate disparate immunogenic properties in a given host. Symbiotic E. coli strains such as E. coli Nissle 1917 (EcN)
Externí odkaz:
https://doaj.org/article/25a28d77ce84464a8ca7a455fcb19ac4
Autor:
Alex Steimle, Julia-Stefanie Frick
Publikováno v:
Journal of Immunology Research, Vol 2016 (2016)
How does the host manage to tolerate its own intestinal microbiota? A simple question leading to complicated answers. In order to maintain balanced immune responses in the intestine, the host immune system must tolerate commensal bacteria in the gut
Externí odkaz:
https://doaj.org/article/564c4f36405b44db90f568b239aba37f
Autor:
Alex Steimle, Mareike Neumann, Erica T. Grant, Stéphanie Willieme, Alessandro De Sciscio, Amy Parrish, Markus Ollert, Eiji Miyauchi, Tomoyoshi Soga, Shinji Fukuda, Hiroshi Ohno, Mahesh S. Desai
Given the gut microbiota’s contribution to pathogenesis of autoimmune diseases, microbiota characteristics could potentially be used to predict disease susceptibility or progression. Although various gut commensals have been proposed as risk factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61885a7bf8a3c5064cb56f52db2d7e15
https://doi.org/10.1101/2023.04.14.536901
https://doi.org/10.1101/2023.04.14.536901
Autor:
Mathis Wolter, Erica T. Grant, Eric C. Martens, Mahesh Desai, Gabriel V. Pereira, Alex Steimle, Marie Boudaud
Publikováno v:
Wolter, M, Grant, E T, Boudaud, M, Steimle, A, Pereira, G V, Martens, E C & Desai, M S 2021, ' Leveraging diet to engineer the gut microbiome ', Nature Reviews Gastroenterology and Hepatology, vol. 18, no. 12, pp. 885-902 . https://doi.org/10.1038/s41575-021-00512-7
Autoimmune diseases, including inflammatory bowel disease, multiple sclerosis and rheumatoid arthritis, have distinct clinical presentations but share underlying patterns of gut microbiome perturbation and intestinal barrier dysfunction. Their potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efde8b3b91e76a3fe15b7bafce6da720
https://doi.org/10.1038/s41575-021-00512-7
https://doi.org/10.1038/s41575-021-00512-7