Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Alex Shimura Yamashita"'
ERK signaling promotes resistance to TRK kinase inhibition in NTRK fusion-driven glioma mouse models
Autor:
Sebastian Schmid, Zachary R. Russell, Alex Shimura Yamashita, Madeline E. West, Abigail G. Parrish, Julia Walker, Dmytro Rudoy, James Z. Yan, David C. Quist, Betemariyam N. Gessesse, Neriah Alvinez, Kimberly D. Hill, Larry W. Anderson, Patrick J. Cimino, Debra K. Kumasaka, Ralph E. Parchment, Eric C. Holland, Frank Szulzewsky
Publikováno v:
Cell Reports, Vol 43, Iss 10, Pp 114829- (2024)
Summary: Pediatric-type high-grade gliomas frequently harbor gene fusions involving receptor tyrosine kinase genes, including neurotrophic tyrosine kinase receptor (NTRK) fusions. Clinically, these tumors show high initial response rates to tyrosine
Externí odkaz:
https://doaj.org/article/4470af9805e444e2b122261c594c9aa1
Autor:
Rafael Sebastián Fort, Cecilia Mathó, Murilo Vieira Geraldo, María Carolina Ottati, Alex Shimura Yamashita, Kelly Cristina Saito, Katia Ramos Moreira Leite, Manuel Méndez, Noemí Maedo, Laura Méndez, Beatriz Garat, Edna Teruko Kimura, José Roberto Sotelo-Silveira, María Ana Duhagon
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-13 (2018)
Abstract Background Nc886 is a 102 bp non-coding RNA transcript initially classified as a microRNA precursor (Pre-miR-886), later as a divergent homologue of the vault RNAs (vtRNA 2–1) and more recently as a novel type of RNA (nc886). Although nc88
Externí odkaz:
https://doaj.org/article/bee1129aa057406aab9a20d1c9b24fab
Publikováno v:
Cancer Research. 83:4941-4941
Glioblastoma (GBM) is an aggressive and deadly brain cancer with a one-year median survival due to the lack of effective targeted treatments. Our goal is to develop a small molecule inhibitor targeting RPN13 protein in the 19S proteasome complex as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f246362029b995c148114b617b717b6f
https://doi.org/10.1158/1538-7445.am2023-4941
https://doi.org/10.1158/1538-7445.am2023-4941
Publikováno v:
Neuro Oncol
Background Isocitrate Dehydrogenase 1/2 (IDH1/2) mutations are diagnostic for Astrocytoma or Oligodendroglioma, IDH-mutant. In these IDH-mutant gliomas, retinoic acid-related gene expression is commonly silenced by DNA hypermethylation. DNA demethyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33ce6fb38093ccf9bccd7ed357235d51
https://doi.org/10.1093/neuonc/noab263
https://doi.org/10.1093/neuonc/noab263
Autor:
Alex Shimura Yamashita, Robson Eder, Daniela Caetano Gonçalves, Alessandro Laviano, Fábio Santos Lira, Luiz Carlos Carnevali Junior, Marilia Seelaender
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Web of Science
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Universidade de São Paulo (USP)
instacron:USP
Web of Science
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Made available in DSpace on 2020-12-10T19:39:22Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-10-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efeda3b74ce03e9b5a06ef8c5022528d
https://doi.org/10.1016/j.clnu.2018.09.023
https://doi.org/10.1016/j.clnu.2018.09.023
Autor:
Alex Shimura Yamashita, Timothy A. Chan, Marina da Costa Rosa, Gregory J. Riggins, William T. Festuccia, Alexandra Borodovsky
Publikováno v:
Neuro-Oncology. 21:189-200
Background Isocitrate deyhydrogenase (IDH) mutant glioma comprises the majority of grades II-III gliomas and nearly all secondary glioblastomas. These progressive gliomas arise from mutations in IDH1 or IDH2 that pathologically produce D-2-hydroxyglu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3676e8fa1b42f1a6cf9dd78f6ea7f688
https://doi.org/10.1093/neuonc/noy146
https://doi.org/10.1093/neuonc/noy146
Autor:
Angela Castoldi, Maynara L. Andrade, Juliana Magdalon, Thiago Belchior, Marcos Yukio Yoshinaga, Niels Olsen Saraiva Câmara, William T. Festuccia, Vivian A. Paschoal, Patricia Chimin, Sayuri Miyamoto, Érique Castro, Alex Shimura Yamashita, Adriano B. Chaves-Filho
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Journal of Lipid Research, Vol 58, Iss 9, Pp 1797-1807 (2017)
Universidade de São Paulo (USP)
instacron:USP
Journal of Lipid Research, Vol 58, Iss 9, Pp 1797-1807 (2017)
Mechanistic target of rapamycin complex (mTORC)1 activity is increased in adipose tissue of obese insulin-resistant mice, but its role in the regulation of tissue inflammation is unknown. Herein, we investigated the effects of adipocyte mTORC1 defici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7368e978645c198fc7a1c62b1165e6c8
https://doi.org/10.1194/jlr.m074518
https://doi.org/10.1194/jlr.m074518
Autor:
Edson Alves de Lima Junior, Gustavo D. Pimentel, Luís G O de Sousa, José Cesar Rosa Neto, Cinara L. Gonçalves, Ronaldo Vagner Thomatieli dos Santos, Fábio Santos Lira, Alex Shimura Yamashita, Emilio L. Streck
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle. 7:615-625
Background Cancer is considered the second leading cause of death in the world, and for the treatment of this disease, pharmacological intervention strategies are frequently based on chemotherapy. Doxorubicin (DOX) is one of the most widely used chem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::362f77c785234f8247992cc7662869c8
https://doi.org/10.1002/jcsm.12104
https://doi.org/10.1002/jcsm.12104
Autor:
María Carolina Ottati, Murilo Vieira Geraldo, Beatriz Garat, Manuel Méndez, Laura Méndez, Cecilia Mathó, Rafael Sebastián Fort, José R. Sotelo-Silveira, Noemí Maedo, María Ana Duhagon, Katia R. M. Leite, Edna Teruko Kimura, Kelly Cristina Saito, Alex Shimura Yamashita
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
BMC Cancer, Vol 18, Iss 1, Pp 1-13 (2018)
COLIBRI
Universidad de la República
instacron:Universidad de la República
BMC Cancer
Universidade de São Paulo (USP)
instacron:USP
BMC Cancer, Vol 18, Iss 1, Pp 1-13 (2018)
COLIBRI
Universidad de la República
instacron:Universidad de la República
BMC Cancer
Background Nc886 is a 102 bp non-coding RNA transcript initially classified as a microRNA precursor (Pre-miR-886), later as a divergent homologue of the vault RNAs (vtRNA 2–1) and more recently as a novel type of RNA (nc886). Although nc886/vtRNA2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::476fb50f6f2b4cdf7f96d9efe38721cc
Autor:
Thiago Belchior, José César Rosa, Fábio Santos Lira, Alex Shimura Yamashita, Nicolette C. Bishop, William T. Festuccia, Barbara Wessner
Publikováno v:
Mediators of Inflammation, Vol 2018 (2018)
Mediators of Inflammation
Mediators of Inflammation
Visceral obesity is frequently associated with the development of type 2 diabetes (T2D), a highly prevalent chronic disease that features insulin resistance and pancreatic β-cell dysfunction as important hallmarks. Recent evidence indicates that the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de6977c81c8c1077a456c23713e03ee6
https://phaidra.univie.ac.at/o:1061896
https://phaidra.univie.ac.at/o:1061896