Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Alex Scopton"'
Publikováno v:
The FASEB Journal. 36
Publikováno v:
Clinical Cancer Research. 28:PR05-PR05
Purpose: We recently developed a chemical strategy for the diversification and disease-specific improvement of tool and FDA-approved kinase inhibitors, and sought to use this strategy for genotype-specific drug discovery in hepatocellular carcinoma (
Autor:
Alex Scopton, T. Ross Kelly
Publikováno v:
The Journal of Organic Chemistry. 70:10004-10012
[reaction: see text] The total synthesis of HKI 0231B (1b) was completed in 12 linear steps and 15.6% overall yield. An unusual anionic cyclization provided access to intermediate 61 and the embedded benz[cd]indol-3-(1H)-one ring system 3. Directed o
Autor:
Dalia Barsyte-Lovejoy, Peter Brown, Richard Marcellus, Wolfram Tempel, John E. Dick, Masoud Vedadi, Roxana E. Iacob, Alexander J. Federation, Carly Griffin, Jun Qi, Emma J. Chory, Rima Al-awar, Amy K. Wernimont, John R. Engen, Ahmed Aman, Alex Scopton, Matthieu Schapira, Fengling Li, Jason J. Marineau, Guillermina Estiu, James E. Bradner, Taraneh Hajian, Tatiana Shatseva, Wenyu Yu, Joanna Yi, Cheryl H. Arrowsmith, Javier Pineda, Erno Wienholds
Publikováno v:
Nature Communications. 4
Nature Communications 3: Article number: 1288 (2012); Published: 18 December 2012; Updated: 21 May 2013. While this Article was undergoing peer review, Basavapathruni et al. published co-crystal structures of EPZ004777 and related compounds in comple
Autor:
Emma J. Chory, Jun Qi, Joanna Yi, John R. Engen, Masoud Vedadi, Dalia Barsyte-Lovejoy, Cheryl H. Arrowsmith, Guillermina Estiu, Matthieu Schapira, Wolfram Tempel, John E. Dick, Carly Griffin, Erno Wienholds, Taraneh Hajian, Rima Al-awar, Tatiana Shatseva, James E. Bradner, Wenyu Yu, Jason J. Marineau, Richard Marcellus, Alex Scopton, Amy K. Wernimont, Fengling Li, Javier Pineda, Ahmed Aman, Peter Brown, Roxana E. Iacob, Alexander J. Federation
Publikováno v:
Nature communications. 3
Selective inhibition of protein methyltransferases is a promising new approach to drug discovery. An attractive strategy towards this goal is the development of compounds that selectively inhibit binding of the cofactor, S-adenosylmethionine, within
Autor:
Alex Scopton, T. Ross Kelly
Publikováno v:
ChemInform. 37
Autor:
T. Ross Kelly, Alex Scopton
Publikováno v:
Organic letters. 6(21)
[reaction: see text] The first total synthesis of the only known naturally occurring azaacridone alkaloid (1) has been achieved in 10 steps from phloroglucinol. A variety of ortholithiation reactions are described, and a method for overcoming the ori