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Rapid engineering of SARS-CoV-2 therapeutic antibodies to increase breadth of neutralization including BQ.1.1, CA.3.1, CH.1.1, XBB.1.16, and XBB.1.5

Autor: Kevin C Entzminger, Jonathan K Fleming, Paul D Entzminger, Lisa Yuko Espinosa, Alex Samadi, Yuko Hiramoto, Shigeru C J Okumura, Toshiaki Maruyama

Publikováno v: Antibody Therapeutics.

SARS-CoV-2 Omicron variant XBB.1.5 has shown extraordinary immune escape even for fully vaccinated individuals. There are currently no approved antibodies that neutralize this variant, and continued emergence of new variants puts immunocompromised an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6ee6343f72db2fe69605d3bec718efde
https://doi.org/10.1093/abt/tbad006

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Rapid engineering of SARS-CoV-2 therapeutic antibodies to increase breadth of neutralization including XBB.1.5 and BQ.1.1

Autor: Kevin C. Entzminger, Jonathan K. Fleming, Paul D. Entzminger, Lisa Yuko Espinosa, Alex Samadi, Yuko Hiramoto, CJ Okumura, Toshiaki Maruyama

An antibody panel that broadly neutralizes currently circulating Omicron variants was obtained byin vitroaffinity maturation using phage display. Starting from a single parent clone, antibody engineering was performed in iterative stages in real time

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cbfb3a788a22b39396c9c80a216adcdb
https://doi.org/10.1101/2023.01.25.525589

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