Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Alex S. Nord"'
Autor:
Timothy A. Fenton, Olivia Y. Haouchine, Elizabeth B. Hallam, Emily M. Smith, Kiya C. Jackson, Darlene Rahbarian, Cesar P. Canales, Anna Adhikari, Alex S. Nord, Roy Ben-Shalom, Jill L. Silverman
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Disruption of SYNGAP1 directly causes a genetically identifiable neurodevelopmental disorder (NDD) called SYNGAP1-related intellectual disability (SRID). Without functional SynGAP1 protein, individuals are developmentally delayed and have pr
Externí odkaz:
https://doaj.org/article/342ace3d29f742d2bb545fc65e6bb4f1
Autor:
Siavash Fazel Darbandi, Joon-Yong An, Kenneth Lim, Nicholas F. Page, Lindsay Liang, David M. Young, Athena R. Ypsilanti, Matthew W. State, Alex S. Nord, Stephan J. Sanders, John L.R. Rubenstein
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114329- (2024)
Summary: Many autism spectrum disorder (ASD)-associated genes act as transcriptional regulators (TRs). Chromatin immunoprecipitation sequencing (ChIP-seq) was used to identify the regulatory targets of ARID1B, BCL11A, FOXP1, TBR1, and TCF7L2, ASD-ass
Externí odkaz:
https://doaj.org/article/96b97b7930204f6ea8932076d915ef71
Autor:
Rinaldo Catta-Preta, Iva Zdilar, Bradley Jenner, Emily T. Doisy, Kayleen Tercovich, Alex S. Nord, Gene G. Gurkoff
Publikováno v:
Neurotrauma Reports, Vol 2, Iss 1, Pp 512-525 (2021)
Traumatic brain injury (TBI) causes acute and lasting impacts on the brain, driving pathology along anatomical, cellular, and behavioral dimensions. Rodent models offer an opportunity to study the temporal progression of disease from injury to recove
Externí odkaz:
https://doaj.org/article/4b6de5928e794e99a731f67c46d51311
Autor:
Jessica L. Haigh, Anna Adhikari, Nycole A. Copping, Tyler Stradleigh, A. Ayanna Wade, Rinaldo Catta-Preta, Linda Su-Feher, Iva Zdilar, Sarah Morse, Timothy A. Fenton, Anh Nguyen, Diana Quintero, Samrawit Agezew, Michael Sramek, Ellie J. Kreun, Jasmine Carter, Andrea Gompers, Jason T. Lambert, Cesar P. Canales, Len A. Pennacchio, Axel Visel, Diane E. Dickel, Jill L. Silverman, Alex S. Nord
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-22 (2021)
Abstract Background Genes with multiple co-active promoters appear common in brain, yet little is known about functional requirements for these potentially redundant genomic regulatory elements. SCN1A, which encodes the NaV1.1 sodium channel alpha su
Externí odkaz:
https://doaj.org/article/78fe0a2d5b104a109781adedaf6df4e5
Autor:
A. Ayanna Wade, Jelle van den Ameele, Seth W. Cheetham, Rebecca Yakob, Andrea H. Brand, Alex S. Nord
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103234- (2021)
Summary: Genetic studies of autism have revealed causal roles for chromatin remodeling gene mutations. Chromodomain helicase DNA binding protein 8 (CHD8) encodes a chromatin remodeler with significant de novo mutation rates in sporadic autism. Howeve
Externí odkaz:
https://doaj.org/article/4d31afdb8ce6460180b433cbe96604ab
Autor:
Magnus Sandberg, Leila Taher, Jianxin Hu, Brian L. Black, Alex S. Nord, John L. R. Rubenstein
Publikováno v:
Neural Development, Vol 13, Iss 1, Pp 1-12 (2018)
Abstract Background Homeodomain (HD) transcription factor (TF) NKX2–1 critical for the regional specification of the medial ganglionic eminence (MGE) as well as promoting the GABAergic and cholinergic neuron fates via the induction of TFs such as L
Externí odkaz:
https://doaj.org/article/225ad96a12994e8e99c25282279aed90
Autor:
Susan Lindtner, Rinaldo Catta-Preta, Hua Tian, Linda Su-Feher, James D. Price, Diane E. Dickel, Vanille Greiner, Shanni N. Silberberg, Gabriel L. McKinsey, Michael T. McManus, Len A. Pennacchio, Axel Visel, Alex S. Nord, John L.R. Rubenstein
Publikováno v:
Cell Reports, Vol 28, Iss 8, Pp 2048-2063.e8 (2019)
Summary: DLX transcription factors (TFs) are master regulators of the developing vertebrate brain, driving forebrain GABAergic neuronal differentiation. Ablation of Dlx1&2 alters expression of genes that are critical for forebrain GABAergic developme
Externí odkaz:
https://doaj.org/article/326f0e1b8fd34b5e82acec04b4ab2a64
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2019)
The packaging of DNA into chromatin determines the transcriptional potential of cells and is central to eukaryotic gene regulation. Case sequencing studies have revealed mutations to proteins that regulate chromatin state, known as chromatin remodeli
Externí odkaz:
https://doaj.org/article/4b3524849b56475b971b7cf918ee7b55
Autor:
Carole Ober, Alex S. Nord, Emma E. Thompson, Lin Pan, Zheng Tan, Darren Cusanovich, Ying Sun, Raluca Nicolae, Celina Edelstein, Daniel H. Schneider, Christine Billstrand, Ditta Pfaffinger, Natasha Phillips, Rebecca L. Anderson, Binu Philips, Ramakrishnan Rajagopalan, Thomas S. Hatsukami, Mark J. Rieder, Patrick J. Heagerty, Deborah A. Nickerson, Mark Abney, Santica Marcovina, Gail P. Jarvik, Angelo M. Scanu, Dan L. Nicolae
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 5, Pp 798-806 (2009)
Plasma lipoprotein(a) (Lp[a]) level is an independent risk factor of cardiovascular disease that is under strong genetic control. We conducted a genome-wide association study of plasma Lp(a) in 386 members of a founder population that adheres to a co
Externí odkaz:
https://doaj.org/article/9443b1ea5a604d939e9e0e0c56c6ed7c
Autor:
Dana C. Crawford, Alex S. Nord, Michael D. Badzioch, Jane Ranchalis, Laura A. McKinstry, Magdalena Ahearn, Caterina Bertucci, Cynthia Shephard, Michelle Wong, Mark J. Rieder, Gerard D. Schellenberg, Deborah A. Nickerson, Patrick J. Heagerty, Ellen M. Wijsman, Gail P. Jarvik
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 3, Pp 588-596 (2008)
The genetic factors associated with carotid artery disease (CAAD) are not fully known. Because of its role in lipid metabolism, we hypothesized that common genetic variation in the very low density lipoprotein receptor (VLDLR) gene is associated with
Externí odkaz:
https://doaj.org/article/1f0d6ddc296946d1b0f929ab51f9c223