Zobrazeno 1 - 10
of 223
pro vyhledávání: '"Alex S. Evers"'
Autor:
Hiroki Tateiwa, Satyanarayana M. Chintala, Ziwei Chen, Lei Wang, Fatima Amtashar, John Bracamontes, Allison L. Germann, Spencer R. Pierce, Douglas F. Covey, Gustav Akk, Alex S. Evers
Publikováno v:
Biomolecules, Vol 13, Iss 2, p 341 (2023)
The neurosteroid allopregnanolone (ALLO) and pregnanolone (PREG), are equally effective positive allosteric modulators (PAMs) of GABAA receptors. Interestingly, the PAM effects of ALLO are strongly enantioselective, whereas those of PREG are not. Thi
Externí odkaz:
https://doaj.org/article/e4ad4ccbe5754819a06d9c298b618207
Autor:
Thaddeus P. Budelier, Christopher Ryan King, Shreya Goswami, Anchal Bansal, Stephen H. Gregory, Troy S. Wildes, Joanna Abraham, Sherry L. McKinnon, Amy Cooper, Ivan Kangrga, Jackie L. Martin, Jr., Melissa Milbrandt, Alex S. Evers, Michael S. Avidan
Publikováno v:
F1000Research, Vol 9 (2020)
Introduction: The post-anesthesia care unit (PACU) is a clinical area designated for patients recovering from invasive procedures. There are typically several geographically dispersed PACUs within hospitals. Patients in the PACU can be unstable and a
Externí odkaz:
https://doaj.org/article/6784fef9f8ca4c9da344289bb6db07ed
Autor:
Yusuke Sugasawa, Wayland WL Cheng, John R Bracamontes, Zi-Wei Chen, Lei Wang, Allison L Germann, Spencer R Pierce, Thomas C Senneff, Kathiresan Krishnan, David E Reichert, Douglas F Covey, Gustav Akk, Alex S Evers
Publikováno v:
eLife, Vol 9 (2020)
This study examines how site-specific binding to three identified neurosteroid-binding sites in the α1β3 GABAA receptor (GABAAR) contributes to neurosteroid allosteric modulation. We found that the potentiating neurosteroid, allopregnanolone, but n
Externí odkaz:
https://doaj.org/article/28aa0ecba7e8446f9f22fbe67ffe09fd
Autor:
Zi-Wei Chen, John R Bracamontes, Melissa M Budelier, Allison L Germann, Daniel J Shin, Krishnan Kathiresan, Ming-Xing Qian, Brad Manion, Wayland W L Cheng, David E Reichert, Gustav Akk, Douglas F Covey, Alex S Evers
Publikováno v:
PLoS Biology, Vol 17, Iss 3, p e3000157 (2019)
Neurosteroids are endogenous modulators of neuronal excitability and nervous system development and are being developed as anesthetic agents and treatments for psychiatric diseases. While gamma amino-butyric acid Type A (GABAA) receptors are the prim
Externí odkaz:
https://doaj.org/article/a27cab63789b480aa2cf6c0a29f66e70
Autor:
Nicholas Hoppe, Simone Harrison, Sun-Hee Hwang, Ziwei Chen, Masha Karelina, Ishan Deshpande, Carl-Mikael Suomivuori, Vivek R. Palicharla, Samuel P. Berry, Philipp Tschaikner, Dominik Regele, Douglas F. Covey, Eduard Stefan, Debora S. Marks, Jeremy Reiter, Ron O. Dror, Alex S. Evers, Saikat Mukhopadhyay, Aashish Manglik
Publikováno v:
bioRxiv
The orphan G protein-coupled receptor (GPCR) GPR161 is enriched in primary cilia, where it plays a central role in suppressing Hedgehog signaling1. GPR161 mutations lead to developmental defects and cancers2,3,4. The fundamental basis of how GPR161 i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0415060b436de23dff5acd054f84dd90
https://europepmc.org/articles/PMC10245861/
https://europepmc.org/articles/PMC10245861/
Publikováno v:
Current Neuropharmacology. 20:886-890
Neurosteroids are endogenous modulators of GABAA receptors that mediate anxiety, pain, mood and arousal. The 3-hydroxyl epimers, allopregnanolone (3α-OH) and epiallopregnanolone (3β-OH) are both prevalent in the mammalian brain and produce opposite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d37795bbbdf41316fa65659bc4042db
https://doi.org/10.2174/1570159x19666211202150041
https://doi.org/10.2174/1570159x19666211202150041
Publikováno v:
Current Neuropharmacology. 20:90-93
Background : In electrophysiological experiments inhibition of a receptor-channel, such as the GABAA receptor, is measured by co-applying an agonist producing a predefined control response with an inhibitor to calculate the fraction of the control re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51f325df87fea7451054546d4d6b1086
https://doi.org/10.2174/1570159x19666211104142433
https://doi.org/10.2174/1570159x19666211104142433
Publikováno v:
Anesth Analg
Ensuring a productive clinical and research workforce requires bringing together physicians and communities to improve health, by strategic targeting of initiatives with clear and significant public health relevance. Within anesthesiology, the tradit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::450e8ade919df57aae9c53e51145ada8
https://pubmed.ncbi.nlm.nih.gov/35030118
https://pubmed.ncbi.nlm.nih.gov/35030118
Autor:
Hijai R. Shin, Y. Rose Citron, Lei Wang, Laura Tribouillard, Claire S. Goul, Robin Stipp, Yusuke Sugasawa, Aakriti Jain, Nolwenn Samson, Chun-Yan Lim, Oliver B. Davis, David Castaneda-Carpio, Mingxing Qian, Daniel K. Nomura, Rushika M. Perera, Eunyong Park, Douglas F. Covey, Mathieu Laplante, Alex S. Evers, Roberto Zoncu
Publikováno v:
Science (New York, N.Y.), vol 377, iss 6612
Science
Science
Lysosomes coordinate cellular metabolism and growth upon sensing of essential nutrients, including cholesterol. Through bioinformatic analysis of lysosomal proteomes, we identified lysosomal cholesterol signaling (LYCHOS, previously annotated as G pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5679d35b76dd78baa098dc74865d1898
https://escholarship.org/uc/item/8g07j454
https://escholarship.org/uc/item/8g07j454
Autor:
Douglas F. Covey, Alex S. Evers, Yukitoshi Izumi, Jamie L. Maguire, Steven J. Mennerick, Charles F. Zorumski
Publikováno v:
Neuroscience & Biobehavioral Reviews. 149:105191
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d570d4e387a144866dd64a2ba0341125
https://doi.org/10.1016/j.neubiorev.2023.105191
https://doi.org/10.1016/j.neubiorev.2023.105191