Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Alex S Powlesland"'
Autor:
Jane Harper, Katherine J Adams, Giovanna Bossi, Debbie E Wright, Andrea R Stacey, Nicole Bedke, Ruth Martinez-Hague, Dan Blat, Laure Humbert, Hazel Buchanan, Gabrielle S Le Provost, Zoe Donnellan, Ricardo J Carreira, Samantha J Paston, Luise U Weigand, Martina Canestraro, Joseph P Sanderson, Sophie Botta Gordon-Smith, Kate L Lowe, Karolina A Rygiel, Alex S Powlesland, Annelise Vuidepot, Namir J Hassan, Brian J Cameron, Bent K Jakobsen, Joseph Dukes
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0205491 (2018)
Robust preclinical testing is essential to predict clinical safety and efficacy and provide data to determine safe dose for first-in-man studies. There are a growing number of examples where the preclinical development of drugs failed to adequately p
Externí odkaz:
https://doaj.org/article/c3d7165394b5442098ed39f7073a5fbd
Autor:
Zoi Pipirou, Kurt Drickamer, Alex S. Powlesland, Imke Steffen, Maureen E. Taylor, Stefan Pöhlmann
Publikováno v:
Glycobiology
The biochemical properties of mouse LSECtin, a glycan-binding receptor that is a member of the C-type lectin family found on sinusoidal endothelial cells, have been investigated. The C-type carbohydrate-recognition domain of mouse LSECtin, expressed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cd0e005bb592b5668715a18e6937045
https://doi.org/10.1093/glycob/cwr008
https://doi.org/10.1093/glycob/cwr008
Autor:
David F. Smith, Anne Dell, Bérangère Tissot, Stefan Pöhlmann, Kurt Drickamer, Alex S. Powlesland, Maureen E. Taylor, Tanja Fisch
Publikováno v:
Journal of Biological Chemistry
LSECtin is a member of the C-type lectin family of glycan-binding receptors that is expressed on sinusoidal endothelial cells of the liver and lymph nodes. In order to compare the sugar- and pathogen-binding properties of LSECtin with those of relate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d783b09faf43ad7c1cb842c86bd695a
https://doi.org/10.1074/jbc.m706292200
https://doi.org/10.1074/jbc.m706292200
Autor:
Alex S, Powlesland, Adrián, Quintero-Martinez, Paik Gee, Lim, Zoi, Pipirou, Maureen E, Taylor, Kurt, Drickamer
Publikováno v:
Methods in enzymology. 480
Modular calcium-dependent carbohydrate-recognition domains (CRDs) of mammalian glycan-binding receptors (C-type lectins), engineered to have novel glycan-binding selectivity, have been developed as tools for the study of glycans on cell surfaces. Str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2bcf1c2f565b4004306aa111438e5b48
https://pubmed.ncbi.nlm.nih.gov/20816210
https://pubmed.ncbi.nlm.nih.gov/20816210
Publikováno v:
The Journal of Biological Chemistry
Langerin, an endocytic receptor of Langerhans cells, binds pathogens such as human immunodeficiency virus by recognition of surface glycoconjugates and mediates their internalization into Birbeck granules. Langerin has an extracellular region consist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69c6cbe66a0ce1d2c5995c51b0b5b101
http://hdl.handle.net/10044/1/17070
http://hdl.handle.net/10044/1/17070
Autor:
Paik Gee Lim, Kurt Drickamer, Maureen E. Taylor, Adrián Quintero-Martinez, Zoi Pipirou, Alex S. Powlesland
Modular calcium-dependent carbohydrate-recognition domains (CRDs) of mammalian glycan-binding receptors (C-type lectins), engineered to have novel glycan-binding selectivity, have been developed as tools for the study of glycans on cell surfaces. Str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c074b22611847e361b952482c0b4fd4
https://doi.org/10.1016/s0076-6879(10)80009-6
https://doi.org/10.1016/s0076-6879(10)80009-6
Autor:
Kurt Drickamer, Paul G. Hitchen, Maria Teresa Elola, Anne Dell, José Mordoh, Maria Marcela Barrio, Maureen E. Taylor, Alex S. Powlesland, Simon Parry, Sarah A. Graham
Publikováno v:
Glycobiology
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
GalMBP is a fragment of serum mannose-binding protein that has been modified to create a probe for galactose-containing ligands. Glycan array screening demonstrated that the carbohydrate-recognition domain of GalMBP selectively binds common groups of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4af3562eda79758ed52613233800074
https://pubmed.ncbi.nlm.nih.gov/19433864
https://pubmed.ncbi.nlm.nih.gov/19433864
Autor:
Kurt Drickamer, Alex S. Powlesland, Sheng Yan, Sabine A. F. Jégouzo, Maureen E. Taylor, Jacob P. Brady, Sarah A. Graham
Publikováno v:
The Journal of Biological Chemistry
Prolectin, a previously undescribed glycan-binding receptor, has been identified by re-screening of the human genome for genes encoding proteins containing potential C-type carbohydrate-recognition domains. Glycan array analysis revealed that the car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::140f51c370d536bd8eec0ecf223410e7
https://hdl.handle.net/11858/00-001M-0000-0011-563C-911858/00-001M-0000-0011-563E-5
https://hdl.handle.net/11858/00-001M-0000-0011-563C-911858/00-001M-0000-0011-563E-5
Autor:
Yuan Guo, Alex S. Powlesland, Kurt Drickamer, Sumon K. Sadhu, Maureen E. Taylor, Eliot M. Ward
Publikováno v:
The Journal of biological chemistry. 281(29)
The mouse genome sequence has been examined to identify the complete set of proteins related to the human glycanbinding receptor, DC-SIGN. In addition to five SIGNR proteins previously described, a pseudogene, encoding a hypothetical SIGNR6, and a fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8adc627e053394de7ba7a7239e15e7d
https://pubmed.ncbi.nlm.nih.gov/16682406
https://pubmed.ncbi.nlm.nih.gov/16682406
Autor:
Kurt Drickamer, Sumon K. Sadhu, Maureen E. Taylor, Alex S. Powlesland, Yuan Guo, Eliot M. Ward
Publikováno v:
Journal of Biological Chemistry. 281:25867-25868
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d45720f82f3de9c5731e3db669e19d68
https://doi.org/10.1016/s0021-9258(19)35300-1
https://doi.org/10.1016/s0021-9258(19)35300-1