Zobrazeno 1 - 10
of 149
pro vyhledávání: '"Alex S Holehouse"'
Autor:
J Ignacio Gutierrez, Gregory P Brittingham, Yonca Karadeniz, Kathleen D Tran, Arnob Dutta, Alex S Holehouse, Craig L Peterson, Liam J Holt
Publikováno v:
eLife, Vol 11 (2022)
It is increasingly appreciated that intracellular pH changes are important biological signals. This motivates the elucidation of molecular mechanisms of pH sensing. We determined that a nucleocytoplasmic pH oscillation was required for the transcript
Externí odkaz:
https://doaj.org/article/f06c90f995b64e0a8aa9436b5690e618
Autor:
Daniel Griffith, Alex S Holehouse
Publikováno v:
eLife, Vol 10 (2021)
The rise of high-throughput experiments has transformed how scientists approach biological questions. The ubiquity of large-scale assays that can test thousands of samples in a day has necessitated the development of new computational approaches to i
Externí odkaz:
https://doaj.org/article/eea3c378655a42d68e392633fc89bbb7
Autor:
David W Sanders, Chanelle C Jumper, Paul J Ackerman, Dan Bracha, Anita Donlic, Hahn Kim, Devin Kenney, Ivan Castello-Serrano, Saori Suzuki, Tomokazu Tamura, Alexander H Tavares, Mohsan Saeed, Alex S Holehouse, Alexander Ploss, Ilya Levental, Florian Douam, Robert F Padera, Bruce D Levy, Clifford P Brangwynne
Publikováno v:
eLife, Vol 10 (2021)
Many enveloped viruses induce multinucleated cells (syncytia), reflective of membrane fusion events caused by the same machinery that underlies viral entry. These syncytia are thought to facilitate replication and evasion of the host immune response.
Externí odkaz:
https://doaj.org/article/a25f5d2a1fee480aabdd9b8491fcd288
Autor:
Jason D Fernandes, Sarvenaz Sarabipour, Christopher T Smith, Natalie M Niemi, Nafisa M Jadavji, Ariangela J Kozik, Alex S Holehouse, Vikas Pejaver, Orsolya Symmons, Alexandre W Bisson Filho, Amanda Haage
Publikováno v:
eLife, Vol 9 (2020)
Many postdoctoral researchers apply for faculty positions knowing relatively little about the hiring process or what is needed to secure a job offer. To address this lack of knowledge about the hiring process we conducted a survey of applicants for f
Externí odkaz:
https://doaj.org/article/7d3dbae4604a433d99d85fbf4f0d4800
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0228708 (2020)
The biomineralization protein Mms6 has been shown to be a major player in the formation of magnetic nanoparticles both within the magnetosomes of magnetotactic bacteria and as an additive in synthetic magnetite precipitation assays. Previous studies
Externí odkaz:
https://doaj.org/article/2bd8654ae07e4b5b8ab3d9b60e68f3cb
Publikováno v:
eLife, Vol 6 (2017)
Phase transitions of linear multivalent proteins control the reversible formation of many intracellular membraneless bodies. Specific non-covalent crosslinks involving domains/motifs lead to system-spanning networks referred to as gels. Gelation tran
Externí odkaz:
https://doaj.org/article/9e4e7d6cb7f54e61ade9e5571082a0f2
Publikováno v:
New Journal of Physics, Vol 20, Iss 4, p 045002 (2018)
Intracellular biomolecular condensates are membraneless organelles that encompass large numbers of multivalent protein and nucleic acid molecules. The bodies assemble via a combination of liquid–liquid phase separation and gelation. A majority of c
Externí odkaz:
https://doaj.org/article/71db8f5b899e4e7e8dfaa7a77894b6e3
Autor:
Meaghan S. Jankowski, Daniel Griffith, Divya G. Shastry, Jacqueline F. Pelham, Garrett M. Ginell, Joshua Thomas, Pankaj Karande, Alex S. Holehouse, Jennifer M. Hurley
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Organismal physiology is widely regulated by the molecular circadian clock, a feedback loop composed of protein complexes whose members are enriched in intrinsically disordered regions. These regions can mediate protein-protein interactions
Externí odkaz:
https://doaj.org/article/49bef495a3fd4cba89ab0c05a9bd35aa
Autor:
Alex S Holehouse, Kristen M Naegle
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144692 (2015)
BACKGROUND:Protein post-translational modifications (PTMs) are an important aspect of protein regulation. The number of PTMs discovered within the human proteome, and other proteomes, has been rapidly expanding in recent years. As a consequence of th
Externí odkaz:
https://doaj.org/article/7212f57944014c2e86232c6dafcf4eb9
Publikováno v:
Annual Review of Virology. 9:285-306
Viruses frequently carry out replication in specialized compartments within cells. The effect of these structures on virus replication is poorly understood. Recent research supports phase separation as a foundational principle for organization of cel