Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Alex S Genshaft"'
Autor:
Alex S Genshaft, Carly G. K. Ziegler, Constantine N. Tzouanas, Benjamin E. Mead, Alex M. Jaeger, Andrew W. Navia, Ryan P. King, Miyeko D. Mana, Siyi Huang, Vanessa Mitsialis, Scott B. Snapper, Ömer H. Yilmaz, Tyler Jacks, Jeffrey F. Van Humbeck, Alex K. Shalek
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Spatial transcriptomics aims to pair omic data with tissue structure. Here the authors report Spatially PhotoActivatable Colour Encoded Cell Address Tags (SPACECAT) to track and isolate live cells by location; this enables spatially informed downstre
Externí odkaz:
https://doaj.org/article/1dca5ab3f8864e5791c305a732202ce2
Autor:
Alex S. Genshaft, Sonu Subudhi, Arlin Keo, Juan Diego Sanchez Vasquez, Nádia Conceição-Neto, Deeqa Mahamed, Lauke L. Boeijen, Nadia Alatrakchi, Chris Oetheimer, Mike Vilme, Riley Drake, Ira Fleming, Nancy Tran, Constantine Tzouanas, Jasmin Joseph-Chazan, Martin Arreola Villanueva, Harmen J. G. van de Werken, Gertine W. van Oord, Zwier M.A. Groothuismink, Boris J. Beudeker, Zgjim Osmani, Shirin Nkongolo, Aman Mehrotra, Kurt Spittaels, Jordan Feld, Raymond T. Chung, Robert J. de Knegt, Harry L. A. Janssen, Jeroen Aerssens, Jacques Bollekens, Nir Hacohen, Georg M. Lauer, Andre Boonstra, Alex K. Shalek, Adam J. Gehring
Publikováno v:
Hepatology.
Autor:
Gertine W. van Oord, Jasmin Joseph-Chazan, Raymond T. Chung, Jordan J. Feld, Juan D. Sanchez Vasquez, Chris Oetheimer, Martin Arreola Villanueva, Ira Fleming, Nir Hacohen, Alex S. Genshaft, Georg M. Lauer, Nancy Tran, Sonu Subudhi, Alex K. Shalek, Jacques Bollekens, Lauke L. Boeijen, Nadia Conceição-Neto, Aman Mehrotra, Adam J. Gehring, Nadia Alatrakchi, Arlin Keo, Constantine Tzouanas, Boris J. B. Beudeker, Zgjim Osmani, Robert J. de Knegt, Mike Vilme, Jeroen Aerssens, Harmen J.G. van de Werken, Harry L.A. Janssen, Shirin Nkongolo, Deeqa Mahamed, Andre Boonstra, Zwier M. A. Groothuismink, Riley Drake
Blood samples are frequently collected in human studies of the immune system but poorly represent tissue-resident immunity. Understanding the immunopathogenesis of tissue-restricted diseases, such as chronic hepatitis B, necessitates direct investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e22266594a757319da157dc9cd79ba9a
https://doi.org/10.1101/2021.11.30.470634
https://doi.org/10.1101/2021.11.30.470634
Autor:
Ryan P. King, Scott B. Snapper, Jeffrey F. Van Humbeck, Constantine N. Tzouanas, Carly G. K. Ziegler, Vanessa Mitsialis, Tyler Jacks, Benjamin E. Mead, Siyi Huang, Miyeko D. Mana, Alex M. Jaeger, Alex K. Shalek, Andrew W. Navia, Ömer H. Yilmaz, Alex S. Genshaft
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Nature Communications
Nature Communications
A cell's phenotype and function are influenced by dynamic interactions with its microenvironment. To examine cellular spatiotemporal activity, we developed SPACECAT-Spatially PhotoActivatable Color Encoded Cell Address Tags-to annotate, track, and is
Autor:
Constantine N. Tzouanas, Vanessa Mitsialis, Tyler Jacks, Benjamin E. Mead, Scott B. Snapper, Alex M. Jaeger, Jeffrey F. Van Humbeck, Alex S. Genshaft, Siyi Huang, Ömer H. Yilmaz, Ryan P. King, Carly G. K. Ziegler, Alex K. Shalek, Andrew W. Navia, Miyeko D. Mana
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
A cell’s phenotype and function are influenced by dynamic interactions with its microenvironment. To examine cellular spatiotemporal activity, we developed SPACECAT—Spatially PhotoActivatable Color Encoded Cell Address Tags—to annotate, track,
Autor:
Alex S. Genshaft, Sonu Subudhi, Arlin Keo, Juan D. Sanchez Vasquez, Nádia Conceição-Neto, Deeqa Mahamed, Lauke L. Boeijen, Nadia Alatrakchi, Chris Oetheimer, Mike Vilme, Riley Drake, Ira Fleming, Nancy Tran, Constantine Tzouanas, Jasmin Joseph-Chazan, Martin Arreola Villanueva, Harmen J. G. van de Werken, Gertine W. van Oord, Zwier M.A. Groothuismink, Boris J. Beudeker, Zgjim Osmani, Shirin Nkongolo, Aman Mehrotra, Jordan Feld, Raymond T. Chung, Robert J. de Knegt, Harry L.A. Janssen, Jeroen Aerssens, Jacques Bollekens, Nir Hacohen, Georg M. Lauer, Andre Boonstra, Alex Shalek, Adam J. Gehring
Publikováno v:
SSRN Electronic Journal.
Autor:
Golda G. Harris, Lian Duan, Travis A. Pemberton, Alex S. Genshaft, Mustafa Köksal, David W. Christianson, Wayne K. W. Chou, David E. Cane, Mengbin Chen
Publikováno v:
Biochemistry. 56:2010-2023
Terpenoid synthases catalyze isoprenoid cyclization reactions underlying the generation of more than 80,000 natural products. Such dramatic chemodiversity belies the fact that these enzymes generally consist of only three domain folds designated α,
Autor:
Caroline J. Gallant, Alex S. Genshaft, Alex K. Shalek, Sanjay M. Prakadan, Aviv Regev, Martin Lundberg, Spyros Darmanis, Shuqiang Li, Kenneth J. Livak, Joyce Hong, Ulf Landegren, Simon Fredriksson, Carly G. K. Ziegler
Publikováno v:
Genome Biology
BioMed Central
BioMed Central
We present a scalable, integrated strategy for coupled protein and RNA detection from single cells. Our approach leverages the DNA polymerase activity of reverse transcriptase to simultaneously perform proximity extension assays and complementary DNA
Autor:
Samuel W. Kazer, John J. Trombetta, Christine G. Lian, Aleth Gaillard, Monica M. Bertagnolli, Carly G. K. Ziegler, Levi A. Garraway, Alex S. Genshaft, Travis K. Hughes, Christopher Rodman, Alexandra-Chloé Villani, Alex K. Shalek, Asaf Rotem, Kellie E. Kolb, Jia-Ren Lin, Aviv Regev, Orit Rozenblatt-Rosen, Ken Dutton-Regester, Marc H. Wadsworth, George F. Murphy, Charles H. Yoon, Diana Lu, Cory M. Johannessen, Ryan J. Sullivan, Judit Jané-Valbuena, Keith T. Flaherty, Mohammad Fallahi-Sichani, Peter K. Sorger, Ofir Cohen, Sanjay M. Prakadan, Daniel J. Treacy, Aleksandr Andreev, Benjamin Izar, Dennie T. Frederick, Parin Shah, Eliezer M. Van Allen, Itay Tirosh
Publikováno v:
PMC
To explore the distinct genotypic and phenotypic states of melanoma tumors, we applied single-cell RNA sequencing (RNA-seq) to 4645 single cells isolated from 19 patients, profiling malignant, immune, stromal, and endothelial cells. Malignant cells w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f80ae41a78a334c7679aec67ef7c0c0d
https://europepmc.org/articles/PMC4944528/
https://europepmc.org/articles/PMC4944528/
Autor:
Alex K. Shalek, Darrell J. Irvine, Scott R. Manalis, Robert J. Kimmerling, Samuel W. Kazer, Alex S. Genshaft, Paul C. Blainey, Gregory L. Szeto, Jennifer W. Li, Kristofor R. Payer, Jacob Borrajo
Publikováno v:
Nature Publishing Group
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-7 (2016)
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-7 (2016)
We introduce a microfluidic platform that enables off-chip single-cell RNA-seq after multi-generational lineage tracking under controlled culture conditions. We use this platform to generate whole-transcriptome profiles of primary, activated murine C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcdcb51c904cfb8402b0e4885e0bcb0e
http://hdl.handle.net/1721.1/101730
http://hdl.handle.net/1721.1/101730