Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Alex Rohde"'
Autor:
Alex Rohde, Tim Sexton, Erik Espling, George A. Gaitanaris, Christiana Doulami, Alexander Gragerov, Marc A. Gavin
Publikováno v:
Cancer Immunology Research. 8:B45-B45
Extracellular phosphatidylserine (PS) is a potent modulator of immune responses. Various phospholipid scramblases respond to different cellular processes to expose PS either during apoptosis or during activation of multiple cell types, including plat
Autor:
László Ürögdi, Alex Rohde, Jennifer Lynn Gage, Sasha Gragerov, György Dormán, Rene Onrust, Vince Florio, Neil S. Cutshall, Derek Johnston, Andrew Osnowski, Harbol Kevin L, Thomas Neil Wheeler, Lee Mitchell, Wendy MacDonald
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:4155-4159
Cyclic nucleotide phosphodiesterases (PDEs) are represented by a large superfamily of enzymes. A series of hydrazone-based inhibitors was synthesized and shown to be novel, potent, and selective against PDE10A. Optimized compounds of this class were
Autor:
Hongkui Zeng, Maria N. Pavlova, Alex Rohde, Alexander Gragerov, Brian A. Schimpf, John E. Bergmann
Publikováno v:
Molecular Endocrinology. 21:2795-2804
TRH is a neuropeptide with a variety of hormonal and neurotransmitter/neuromodulator functions. In particular, TRH has pronounced acute antidepressant effects in both humans and animals and has been implicated in the mediation of the effects of other
Autor:
Maria N. Pavlova, Emilie F. Rissman, Donald K. Clifton, Anika A. McPhie-Lalmansingh, Cristian Bodo, Alexander S. Kauffman, Alex Rohde, Jin Ho Park, John G. Hohmann, Robert A. Steiner, Michelle L. Gottsch
Publikováno v:
The Journal of Neuroscience. 27:8826-8835
GPR54 is a G-protein-coupled receptor, which binds kisspeptins and is widely expressed throughout the brain. Kisspeptin–GPR54 signaling has been implicated in the regulation of pubertal and adulthood gonadotropin-releasing hormone (GnRH) secretion,
Autor:
George A. Gaitanaris, Hui Xu, Hongkui Zeng, Hiroki Toyoda, Maria N. Pavlova, John G. Hohmann, John E. Bergmann, Rene Onrust, Alex Rohde, Brian A. Schimpf, Galina Gragerova, Ming Gao Zhao, Alexander Gragerov, Min Zhuo, Long Jun Wu
Publikováno v:
Molecular and Cellular Biology. 26:9352-9363
Neuromedin U (NMU) is a highly conserved neuropeptide with a variety of physiological functions mediated by two receptors, peripheral NMUR1 and central nervous system NMUR2. Here we report the generation and phenotypic characterization of mice defici
Publikováno v:
Proceedings of the National Academy of Sciences. 99:5509-5514
It is unclear whether the core promoter is involved in developmental regulation. To address this question, we mutated the TATA box of the human gamma-globin gene, produced transgenic mice, and examined the effect of the mutation during the course of
Autor:
Betty Nakamoto, Gregory V. Priestley, Thalia Papayannopoulou, Kenneth R. Peterson, Alex Rohde
Publikováno v:
Blood. 95:1274-1282
A substantial body of published data suggests activation of lineage-specific genes in multipotential hemopoietic cells before their unilineage commitment. Because the behavior and plasticity of cells isolated in vitro away from microenvironmental con
Publikováno v:
Journal of Biological Chemistry. 273:17361-17367
To delineate the regulation of the human e-globin gene, we investigated e-gene expression during the development of transgenic mice carrying constructs with e-promoter truncations linked to a micro-locus control region (μLCR). Expression levels were
Autor:
Lauren Hamilton, Rene Onrust, Thomas Neil Wheeler, Charles Prince Zuta, Sasha Gragerov, Alex Rohde, Shawn McKee, Neil S. Cutshall, Jennifer Lynn Gage, Vince Florio, Harbol Kevin L, Galina Gragerova, Hui-Rong Shen
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(17)
A series of 2-methoxyacylhydrazones were optimized to yield compounds with high affinity for PDE10A. Several compounds demonstrated efficacy in animal models of schizophrenia, including conditioned avoidance response and a pro-psychotic phencyclidine
Autor:
Hongkui Zeng, Kyoji Horie, Linda Madisen, Maria Pavlova, Galina Gragerova, Alex Rohde, Brian Schimpf, Yuqiong Liang, Ethan Ojala, Farah Kramer, Patricia Roth, Olga Slobodskaya, Io Dolka, Eileen Southon, Lino Tessarollo, Karin Bornfeldt, Alexander Gragerov, George Pavlakis, George Gaitanaris
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af0bba33407b1db403262b45409d6da9
https://doi.org/10.1201/b12876-15
https://doi.org/10.1201/b12876-15