Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Alex R.B. Thomsen"'
Autor:
Jan Steyaert, Søren Heissel, Thomas J. Cahill, Tara C. Marcink, Li-Yin Huang, Oliver B. Clarke, Robert J. Lefkowitz, Sarah Triest, Chuan Hong, Rick Huang, Anthony H. Nguyen, Henrik Molina, Yong Zi Tan, Fadi Samaan, John Little, Alex R.B. Thomsen, Amedee des Georges, Xin Chen, Danya Ben-Hail, Ali Masoudi, Venkata P. Dandey, Roger K. Sunahara, Jacob P. Mahoney, Zhiheng Yu
Publikováno v:
Nature structural & molecular biology, vol 26, iss 12
Nature structural & molecular biology
Nature structural & molecular biology
Classically, G-protein-coupled receptors (GPCRs) are thought to activate G protein from the plasma membrane and are subsequently desensitized by β-arrestin (β-arr). However, some GPCRs continue to signal through G protein from internalized compartm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e18a6aba2b7ec4c7d8d6ca44df34d176
https://escholarship.org/uc/item/45b1h5kr
https://escholarship.org/uc/item/45b1h5kr
Autor:
Ryan T. Strachan, Arun K. Shukla, Annie M. Dosey, Billy Breton, Michel Bouvier, Li-Yin Huang, Thomas J. Cahill, Franziska M. Heydenreich, Alex R.B. Thomsen, Georgios Skiniotis, Bianca Plouffe, Roger K. Sunahara, Alem W. Kahsai, Robert J. Lefkowitz, Jacob P. Mahoney, Biswaranjan Pani, Jeffrey T. Tarrasch
Publikováno v:
Cell
Classically, G protein-coupled receptor (GPCR) stimulation promotes G protein signaling at the plasma membrane, followed by rapid β-arrestin-mediated desensitization and receptor internalization into endosomes. However, it has been demonstrated that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c741c877b23d1350a8156f94e030e5d
https://doi.org/10.1016/j.cell.2016.07.004
https://doi.org/10.1016/j.cell.2016.07.004
Publikováno v:
Trends in pharmacological sciences. 39(10)
G-protein-coupled receptors (GPCRs) are conventionally considered to function at the plasma membrane, where they detect extracellular ligands and activate heterotrimeric G proteins that transmit intracellular signals. Consequently, drug discovery eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbe9b4143218bf2da8b2ca071e0dba9a
https://pubmed.ncbi.nlm.nih.gov/30180973
https://pubmed.ncbi.nlm.nih.gov/30180973
Autor:
Yujing Sun, Dongfang He, Yu-Jing Lu, Ming-Liang Ma, Jian-Yuan Li, Zhao Yang, Alem W. Kahsai, Zhigang Xu, Jin-Peng Sun, Fan Yi, Yi-Jing Wang, Rui-Rui Li, Alex R.B. Thomsen, Wei Kong, Jingxin Li, Yuan Gao, Xiao Yu, Ying-Ying Qin, Hui Lin, Ka Young Chung, Zi-Jiang Chen, Hui Mo, Zong-Lai Liang, Daolai Zhang, Mingyao Liu, Amy Lin, Dali Li, Mengjing Li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa0d41b4ac61acabf196283247bb57f5
https://doi.org/10.7554/elife.33432.051
https://doi.org/10.7554/elife.33432.051
Autor:
Dao Lai Zhang, Rui Rui Li, Zong Lai Liang, Alem W. Kahsai, Alex R.B. Thomsen, Yuan Gao, Dali Li, Yu Jing Lu, Fan Yi, Ying Ying Qin, Ka Young Chung, Hui Mo, Amy Lin, Hui Lin, Jian Yuan Li, Yi Jing Wang, Ming-Liang Ma, Zhigang Xu, Yu Jing Sun, Zhao Yang, Jin-Peng Sun, Wei Kong, Jingxin Li, Xiao Yu, Dong Fang He, Zi-Jiang Chen, Meng Jing Li, Mingyao Liu
Publikováno v:
eLife
eLife, Vol 7 (2018)
eLife, Vol 7 (2018)
Luminal fluid reabsorption plays a fundamental role in male fertility. We demonstrated that the ubiquitous GPCR signaling proteins Gq and β-arrestin-1 are essential for fluid reabsorption because they mediate coupling between an orphan receptor ADGR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7fd3a2d4e47ef62f5246479a7459115
https://pubmed.ncbi.nlm.nih.gov/29393851
https://pubmed.ncbi.nlm.nih.gov/29393851
Autor:
Arun K. Shukla, Xin Chen, Benjamin Berger, John Little, Jane Lamerdin, Chang Xiu Qu, Jan Steyaert, Li-Yin Huang, Daniel L. Bassoni, Albert Antar, Alex R.B. Thomsen, Bryant J. Gavino, Robert J. Lefkowitz, Georgios Skiniotis, Jin-Peng Sun, Thomas J. Cahill, Sarah Triest, Asuka Inoue, Michel Bouvier, Kouki Kawakami, Alem W. Kahsai, Junken Aoki, Anthony H. Nguyen, Fan Yang, Bianca Plouffe, Adi Blanc, Jeffrey T. Tarrasch
β-Arrestins (βarrs) interact with G protein-coupled receptors (GPCRs) to desensitize G protein signaling, to initiate signaling on their own, and to mediate receptor endocytosis. Prior structural studies have revealed two unique conformations of GP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d779b913383d844a88e317c7fec89d4
https://doi.org/10.1073/pnas.1701529114
https://doi.org/10.1073/pnas.1701529114
Autor:
Fan Yang, Zheng Gong, Chuan Yong Liu, Mei Jie Wang, Jin-Peng Sun, Amy Lin, Wen Shuai Zheng, Chun-Hua Liu, Zhixin Liu, Yi Jing Wang, Dong Fang He, Fan Yi, Chang Xiu Qu, Chao Ran Ji, Xiao Yu, Thomas J. Cahill, Alex R.B. Thomsen, Kunhong Xiao, Fu Ai Cui, Yu Hong Wang, Zhuan Zhou, Ming-Liang Ma, Peng Xiao, Zong Lai Liang, Alem W. Kahsai, Tian Xue, Yu Jing Sun
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Acute hormone secretion triggered by G protein-coupled receptor (GPCR) activation underlies many fundamental physiological processes. GPCR signalling is negatively regulated by β-arrestins, adaptor molecules that also activate different intracellula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22a2573c3241cbd6276b942c9ffbe6dc
http://europepmc.org/articles/PMC5309860
http://europepmc.org/articles/PMC5309860
Autor:
Seungkirl Ahn, Robert J. Lefkowitz, Jonathan D. Violin, Ryan T. Strachan, Jin-Peng Sun, David H. Rominger, Andrew B. Kleist, Alex R.B. Thomsen, Xiao Zhu, Tommaso Costa
Publikováno v:
Journal of Biological Chemistry. 289:14211-14224
The concept of "biased agonism" arises from the recognition that the ability of an agonist to induce a receptor-mediated response (i.e. "efficacy") can differ across the multiple signal transduction pathways (e.g. G protein and β-arrestin (βarr)) e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5810f5e05fab45813d5f6263164f8990
https://doi.org/10.1074/jbc.m114.548131
https://doi.org/10.1074/jbc.m114.548131
Publikováno v:
Current Opinion in Cell Biology. 27:18-24
The classic paradigm of G protein-coupled receptor (GPCR) activation was based on the understanding that agonist binding to a receptor induces or stabilizes a conformational change to an “active” conformation. In the past decade, however, it has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ccd9ae4fbeb7a18ee6c35451f38ac99
https://doi.org/10.1016/j.ceb.2013.10.008
https://doi.org/10.1016/j.ceb.2013.10.008