Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Alex R B Thomsen"'
Autor:
Dao-Lai Zhang, Yu-Jing Sun, Ming-Liang Ma, Yi-jing Wang, Hui Lin, Rui-Rui Li, Zong-Lai Liang, Yuan Gao, Zhao Yang, Dong-Fang He, Amy Lin, Hui Mo, Yu-Jing Lu, Meng-Jing Li, Wei Kong, Ka Young Chung, Fan Yi, Jian-Yuan Li, Ying-Ying Qin, Jingxin Li, Alex R B Thomsen, Alem W Kahsai, Zi-Jiang Chen, Zhi-Gang Xu, Mingyao Liu, Dali Li, Xiao Yu, Jin-Peng Sun
Publikováno v:
eLife, Vol 7 (2018)
Luminal fluid reabsorption plays a fundamental role in male fertility. We demonstrated that the ubiquitous GPCR signaling proteins Gq and β-arrestin-1 are essential for fluid reabsorption because they mediate coupling between an orphan receptor ADGR
Externí odkaz:
https://doaj.org/article/160cb752179d4fe99a359e4cf629a263
Autor:
Badr Sokrat, Anthony H. Nguyen, Alex R. B. Thomsen, Li-Yin Huang, Hiroyuki Kobayashi, Alem W. Kahsai, Jihee Kim, Bing X. Ho, Symon Ma, John Little, Catherine Ehrhart, Ian Pyne, Emmery Hammond, Michel Bouvier
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Classically, G protein-coupled receptors (GPCRs) promote signaling at the plasma membrane through activation of heterotrimeric Gαβγ proteins, followed by the recruitment of GPCR kinases and βarrestin (βarr) to initiate receptor desensit
Externí odkaz:
https://doaj.org/article/5849f72408344b829ffc02844067159b
Autor:
Alan Hegron, Chloe J. Peach, Raquel Tonello, Philipp Seemann, Shavonne Teng, Rocco Latorre, Harald Huebner, Dorothee Weikert, Jeanette Rientjes, Nicholas A. Veldhuis, Daniel P. Poole, Dane D. Jensen, Alex R. B. Thomsen, Brian L. Schmidt, Wendy L. Imlach, Peter Gmeiner, Nigel W. Bunnett
Publikováno v:
Proceedings of the National Academy of Sciences. 120
The hypothesis that sustained G protein-coupled receptor (GPCR) signaling from endosomes mediates pain is based on studies with endocytosis inhibitors and lipid-conjugated or nanoparticle-encapsulated antagonists targeted to endosomes. GPCR antagonis
Autor:
Chun-Hua Liu, Zheng Gong, Zong-Lai Liang, Zhi-Xin Liu, Fan Yang, Yu-Jing Sun, Ming-Liang Ma, Yi-Jing Wang, Chao-Ran Ji, Yu-Hong Wang, Mei-Jie Wang, Fu-Ai Cui, Amy Lin, Wen-Shuai Zheng, Dong-Fang He, Chang-xiu Qu, Peng Xiao, Chuan-Yong Liu, Alex R. B. Thomsen, Thomas Joseph Cahill, Alem W. Kahsai, Fan Yi, Kun-Hong Xiao, Tian Xue, Zhuan Zhou, Xiao Yu, Jin-Peng Sun
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Angiotensin II type 1 receptor (AT1R)-mediated acute catecholamine release is modulated by β-arrestin. Here the authors show that β-arrestin-1 recruits the Ca2+channel TRPC3 and the PLCγ to the AT1R-β-arrestin complex, triggering G protein-indepe
Externí odkaz:
https://doaj.org/article/fd8251bd4bfc4bada3441c9bdef9e02e
Autor:
Hyunggu Hahn, Carole Daly, John Little, Nicole A. Perry-Hauser, Asuka Inoue, Bianca Plouffe, Alex R. B. Thomsen
Chemokine receptors are GPCRs that regulate chemotactic migration of a wide variety of cells including immune and cancer cells. Most chemokine receptors contain features associated with the ability to stimulate G proteins during β-arrestin-mediated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98f340dd7684e351e34dc3a23a6d78ec
https://doi.org/10.1101/2022.09.27.509755
https://doi.org/10.1101/2022.09.27.509755
Autor:
Rocco Latorre, Alan Hegron, Chloe J. Peach, Shavonne Teng, Raquel Tonello, Jeffri S. Retamal, Rafael Klein-Cloud, Diana Bok, Dane D. Jensen, Lena Gottesman-Katz, Jeanette Rientjes, Nicholas A. Veldhuis, Daniel P. Poole, Alex R. B. Thomsen, Brian L. Schmidt, Charalabos H. Pothoulakis, Carl Rankin, Ying Xie, Hon Wai Koon, Nigel W. Bunnett
Publikováno v:
Proceedings of the National Academy of Sciences. 119
G protein–coupled receptors (GPCRs) regulate many pathophysiological processes and are major therapeutic targets. The impact of disease on the subcellular distribution and function of GPCRs is poorly understood. We investigated trafficking and sign
Publikováno v:
Plouffe, B, Thomsen, A R B & Irannejad, R 2020, ' Emerging Role of Compartmentalized G Protein-Coupled Receptor Signaling in the Cardiovascular Field ', ACS Pharmacology & Translational Science, vol. 3, no. 2, pp. 221-236 . https://doi.org/10.1021/acsptsci.0c00006
ACS pharmacology & translational science, vol 3, iss 2
ACS Pharmacology & Translational Science
ACS pharmacology & translational science, vol 3, iss 2
ACS Pharmacology & Translational Science
G protein-coupled receptors (GPCRs) are cell surface receptors that for many years have been considered to function exclusively at the plasma membrane, where they bind to extracellular ligands and activate G protein signaling cascades. According to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5c1cfa1dc460aa3d9e020b2e57b7901
https://pure.qub.ac.uk/en/publications/emerging-role-of-compartmentalized-g-proteincoupled-receptor-signaling-in-the-cardiovascular-field(e4214c9e-2717-430b-913f-4fde718f41d3).html
https://pure.qub.ac.uk/en/publications/emerging-role-of-compartmentalized-g-proteincoupled-receptor-signaling-in-the-cardiovascular-field(e4214c9e-2717-430b-913f-4fde718f41d3).html