Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Alex Pines"'
Autor:
Diana A. Llerena Schiffmacher, Shun-Hsiao Lee, Katarzyna W. Kliza, Arjan F. Theil, Masaki Akita, Angela Helfricht, Karel Bezstarosti, Camila Gonzalo-Hansen, Haico van Attikum, Matty Verlaan-de Vries, Alfred C. O. Vertegaal, Jan H. J. Hoeijmakers, Jurgen A. Marteijn, Hannes Lans, Jeroen A. A. Demmers, Michiel Vermeulen, Titia K. Sixma, Tomoo Ogi, Wim Vermeulen, Alex Pines
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Transcription-blocking DNA lesions are specifically targeted by transcription-coupled nucleotide excision repair (TC-NER), which removes a broad spectrum of DNA lesions to preserve transcriptional output and thereby cellular homeostasis to c
Externí odkaz:
https://doaj.org/article/ae22f3558ad948a0bf15ffe295f5314c
Autor:
Arjan F Theil, Alex Pines, Tuğba Kalayci, José M Heredia‐Genestar, Anja Raams, Marion H Rietveld, Sriram Sridharan, Sabine EJ Tanis, Klaas W Mulder, Nesimi Büyükbabani, Birsen Karaman, Zehra O Uyguner, Hülya Kayserili, Jan HJ Hoeijmakers, Hannes Lans, Jeroen AA Demmers, Joris Pothof, Umut Altunoglu, Abdoelwaheb El Ghalbzouri, Wim Vermeulen
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 11, Pp n/a-n/a (2023)
Abstract The brittle hair syndrome Trichothiodystrophy (TTD) is characterized by variable clinical features, including photosensitivity, ichthyosis, growth retardation, microcephaly, intellectual disability, hypogonadism, and anaemia. TTD‐associate
Externí odkaz:
https://doaj.org/article/00a4d41179d0455f867ed390b4be7d8b
Autor:
Namrata Kumar, Arjan F. Theil, Vera Roginskaya, Yasmin Ali, Michael Calderon, Simon C. Watkins, Ryan P. Barnes, Patricia L. Opresko, Alex Pines, Hannes Lans, Wim Vermeulen, Bennett Van Houten
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Nucleotide excision repair proteins are involved in the repair of UV-induced DNA damage. Here, the authors show that NER proteins, DDB2, XPC, and XPA play a vital role in the 8-oxoguanine repair by coordinating with base excision repair protein OGG1.
Externí odkaz:
https://doaj.org/article/677d2112db5041e7bd30b5fcd641a24a
Autor:
Alex Pines, Madelon Dijk, Matthew Makowski, Elisabeth M. Meulenbroek, Mischa G. Vrouwe, Yana van der Weegen, Marijke Baltissen, Pim J. French, Martin E. van Royen, Martijn S. Luijsterburg, Leon H. Mullenders, Michiel Vermeulen, Wim Vermeulen, Navraj S. Pannu, Haico van Attikum
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
An integrated network of chaperones and protein degradation machineries called the proteostasis network (PN) is required to maintain protein homeostasis. Here the authors show that one of the components of the PN, the chaperonin TRiC, interacts with
Externí odkaz:
https://doaj.org/article/349d895dc8574c5db3919c1594d1d33a
Autor:
Namrata Kumar, Arjan F. Theil, Vera Roginskaya, Yasmin Ali, Michael Calderon, Simon C. Watkins, Ryan P. Barnes, Patricia L. Opresko, Alex Pines, Hannes Lans, Wim Vermeulen, Bennett Van Houten
Publikováno v:
Nature Communications, 13(1):974. Nature Publishing Group
UV-DDB, consisting of subunits DDB1 and DDB2, recognizes UV-induced photoproducts during global genome nucleotide excision repair (GG-NER). We recently demonstrated a noncanonical role of UV-DDB in stimulating base excision repair (BER) which raised
Autor:
Jesper V. Olsen, Harry Vrieling, Leon H.F. Mullenders, Bharath Sampadi, Alex Pines, Branislav Misovic, Anton J.L. de Groot, Bob van de Water, Stephanie Munk
Publikováno v:
Archives of Toxicology
Archives of Toxicology, 94(5), 1655-1671. SPRINGER HEIDELBERG
Archives of Toxicology, 94, 1655-1671
Sampadi, B, Pines, A, Munk, S, Mišovic, B, de Groot, A J, van de Water, B, Olsen, J V, Mullenders, L H F & Vrieling, H 2020, ' Quantitative phosphoproteomics to unravel the cellular response to chemical stressors with different modes of action ', Archives of Toxicology, vol. 94, pp. 1655-1671 . https://doi.org/10.1007/s00204-020-02712-7
Archives of Toxicology, 94(5), 1655-1671. SPRINGER HEIDELBERG
Archives of Toxicology, 94, 1655-1671
Sampadi, B, Pines, A, Munk, S, Mišovic, B, de Groot, A J, van de Water, B, Olsen, J V, Mullenders, L H F & Vrieling, H 2020, ' Quantitative phosphoproteomics to unravel the cellular response to chemical stressors with different modes of action ', Archives of Toxicology, vol. 94, pp. 1655-1671 . https://doi.org/10.1007/s00204-020-02712-7
Damage to cellular macromolecules and organelles by chemical exposure evokes activation of various stress response pathways. To what extent different chemical stressors activate common and stressor-specific pathways is largely unknown. Here, we used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49c0066d65e3f36bdb878919dba1e9d6
https://hdl.handle.net/1887/3184412
https://hdl.handle.net/1887/3184412
Autor:
Martin E. van Royen, Joost Schimmel, Esra Klemann, Frauke Liebelt, Yana van der Weegen, Leon H.F. Mullenders, Matty Verlaan-de Vries, Alex Pines, Wim Vermeulen, Alfred C.O. Vertegaal, Martijn S. Luijsterburg
Publikováno v:
Nucleic Acids Research, 48(1), 231-248. OXFORD UNIV PRESS
Nucleic Acids Research
Nucleic Acids Research, 48(1), 231-248. Oxford University Press
Nucleic Acids Research
Nucleic Acids Research, 48(1), 231-248. Oxford University Press
Cockayne Syndrome (CS) is a severe neurodegenerative and premature aging autosomal-recessive disease, caused by inherited defects in the CSA and CSB genes, leading to defects in transcription-coupled nucleotide excision repair (TC-NER) and consequent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31ff3e5697a32c00975edfe2cfa7f1b5
https://hdl.handle.net/1887/3182621
https://hdl.handle.net/1887/3182621
Autor:
Petra Schwertman, Maria Tresini, Marvin van Toorn, Jurgen A. Marteijn, Karel Bezstarosti, Jeroen Demmers, Di Zhou, Alex Pines, Franziska Wienholz, Yasemin Turkyilmaz
Publikováno v:
Nucleic Acids Research, 47(8), 4011-4025. Oxford University Press
Nucleic Acids Research
Nucleic Acids Research
Transcription-coupled nucleotide excision repair (TC-NER) is a dedicated DNA repair pathway that removes transcription-blocking DNA lesions (TBLs). TC-NER is initiated by the recognition of lesion-stalled RNA Polymerase II by the joint action of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da37579101f78f31a79019fa0cb46d6b
https://pure.eur.nl/en/publications/d96ce8f7-9226-4646-8614-1ba5d4e563fb
https://pure.eur.nl/en/publications/d96ce8f7-9226-4646-8614-1ba5d4e563fb
Autor:
David H. Phillips, Yusaku Nakabeppu, Agnieszka Siomek-Gorecka, Jie Zuo, Teruhisa Tsuzuki, Mark D. Evans, Margherita Bignami, Rajinder Singh, Daniel Gackowski, Mutsuo Sekiguchi, Rafal Rozalski, Alex Pines, Kunihiko Sakumi, Marcus S. Cooke, Leon H.F. Mullenders, Ryszard Olinski, Vilas Mistry
Publikováno v:
Free Radical Biology and Medicine. 99:385-391
The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link. Urinary 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-oxodGuo) is a widely measured biomarker of oxidative
Autor:
Leon H.F. Mullenders, Pim J. French, Haico van Attikum, Madelon Dijk, Martijn S. Luijsterburg, Navraj S. Pannu, Mischa G. Vrouwe, Martin E. van Royen, Wim Vermeulen, Elisabeth M. Meulenbroek, Michiel Vermeulen, Matthew M. Makowski, Alex Pines, Yana van der Weegen, Marijke P. Baltissen
Publikováno v:
Nature Communications, 9
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nature Communications, 9, pp. 1-14
Nature Communications, 9:1040. Nature Publishing Group
Nature Communications, 9, 1-14
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nature Communications, 9, pp. 1-14
Nature Communications, 9:1040. Nature Publishing Group
Nature Communications, 9, 1-14
Transcription-blocking DNA lesions are removed by transcription-coupled nucleotide excision repair (TC-NER) to preserve cell viability. TC-NER is triggered by the stalling of RNA polymerase II at DNA lesions, leading to the recruitment of TC-NER-spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f95a3006f2bd3708c2945b52996de77a
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847541/pdf/41467_2018_Article_3484.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847541/pdf/41467_2018_Article_3484.pdf