Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Alex Pinder"'
Autor:
Sandra Pavey, Alex Pinder, Winnie Fernando, Nicholas D’Arcy, Nicholas Matigian, Dubravka Skalamera, Kim‐Anh Lê Cao, Dorothy Loo‐Oey, Michelle M. Hill, Mitchell Stark, Michael Kimlin, Andrew Burgess, Nicole Cloonan, Richard A. Sturm, Brian Gabrielli
Publikováno v:
Molecular Oncology, Vol 14, Iss 1, Pp 22-41 (2020)
Ultraviolet radiation‐induced DNA mutations are a primary environmental driver of melanoma. The reason for this very high level of unrepaired DNA lesions leading to these mutations is still poorly understood. The primary DNA repair mechanism for UV
Externí odkaz:
https://doaj.org/article/8d2a9fd8b0b2495fa4df352e0cc21d2c
Autor:
Michael G. Kimlin, Winnie Fernando, Brian Gabrielli, Andrew Burgess, Kim-Anh Lê Cao, Dorothy Loo-Oey, Nicholas Matigian, Dubravka Skalamera, Michelle M. Hill, Nicholas D’Arcy, Nicole Cloonan, Mitchell S. Stark, Sandra Pavey, Richard A. Sturm, Alex Pinder
Publikováno v:
Molecular Oncology, Vol 14, Iss 1, Pp 22-41 (2020)
Ultraviolet radiation-induced DNA mutations are a primary environmental driver of melanoma. The reason for this very high level of unrepaired DNA lesions leading to these mutations is still poorly understood. The primary DNA repair mechanism for UV-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39559f57a9385457b7cb458c93bf3697
https://doaj.org/article/8d2a9fd8b0b2495fa4df352e0cc21d2c
https://doaj.org/article/8d2a9fd8b0b2495fa4df352e0cc21d2c
Autor:
Alex Pinder, James S. Wilmott, Richard A. Scolyer, Fezal Ozdemir, Isil Kilinc Karaarslan, H. Peter Soyer, Carly Fox, Sandra Pavey, Brian Gabrielli, Kim-Anh Lê Cao, Duncan Lambie, Helmut Schaider, Taner Akalin, Miko Yamada
WOS: 000381303000009
PubMed ID: 27166757
Here we have carried out a multiparameter analysis using a panel of 28 immunohistochemical markers to identify markers of transformation from benign and dysplastic naevus to primary melanoma in three
PubMed ID: 27166757
Here we have carried out a multiparameter analysis using a panel of 28 immunohistochemical markers to identify markers of transformation from benign and dysplastic naevus to primary melanoma in three
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e847cb3923c5ad1d5bd3293265c92056
https://hdl.handle.net/11454/52574
https://hdl.handle.net/11454/52574
Autor:
Andrew Burgess, ShuShyan Wong, Brian Gabrielli, Sandra Pavey, Nichole Giles, Alex Pinder, Matthew Wigan, Richard A. Sturm
Publikováno v:
Journal of Investigative Dermatology. 132:1681-1688
UVR is a major environmental risk factor for the development of melanoma. Here we describe a coupled DNA-damage tolerance (DDT) mechanism and G2-phase cell cycle checkpoint induced in response to suberythemal doses of UVR that is commonly defective i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d46a4ea1406f32f23a808888034b7e7c
https://doi.org/10.1038/jid.2012.41
https://doi.org/10.1038/jid.2012.41
A potent Chk1 inhibitor is selectively cytotoxic in melanomas with high levels of replicative stress
Autor:
Kelly Brooks, B. Edwards, Pamela Mukhopadhyay, Heather Beamish, Brian Gabrielli, Vanessa Oakes, Max V. Ranall, Paul Leo, Sandra Pavey, Alex Pinder, Duncan Lambie
Publikováno v:
Oncogene. 32:788-796
There are few effective treatments for metastatic melanoma. Checkpoint kinase 1 (Chk1) inhibitors are being trialled for their efficacy in enhancing conventional chemotherapeutic agents, but their effectiveness as single agents is not known. We have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14a3a0405c5dd667da720619c6621880
https://doi.org/10.1038/onc.2012.72
https://doi.org/10.1038/onc.2012.72
Publikováno v:
British Journal of Dermatology. 166:362-371
Background Exposure to ultraviolet radiation (UVR) and the familial melanoma susceptibility gene p16 (CDKN2A) are among the major risk factors which have been identified to contribute to the development of melanoma, and also significantly contribute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f42add5cafb9365399ba9a2299b62e28
https://doi.org/10.1111/j.1365-2133.2011.10635.x
https://doi.org/10.1111/j.1365-2133.2011.10635.x
Autor:
Dorothy Loo, Michelle M. Hill, Brian Gabrielli, Alex Pinder, Brittney S. Harrington, Vanessa Oakes
Publikováno v:
Cellular signalling. 27(11)
Cell cycle progression from G2 phase into mitosis is regulated by a complex network of mechanisms, all of which finally control the timing of Cyclin B/CDK1 activation. PLK1 regulates a network of events that contribute to regulating G2/M phase progre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f507aa732285181db3fc5517bdcc6b0e
https://pubmed.ncbi.nlm.nih.gov/26291670
https://pubmed.ncbi.nlm.nih.gov/26291670
Autor:
W. J. Lee, Kee Ming Chia, Alex Pinder, Vanessa Oakes, Sandra Pavey, Brittney S. Harrington, Brian Gabrielli, Weili Wang, Hidemasa Goto, Masaki Inagaki, Heather Beamish
Whereas many components regulating the progression from S phase through G2 phase into mitosis have been identified, the mechanism by which these components control this critical cell cycle progression is still not fully elucidated. Cyclin A/Cdk2 has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4501d61e9a5c1ba787f130006cba683d
https://europepmc.org/articles/PMC4615124/
https://europepmc.org/articles/PMC4615124/
Publikováno v:
BMC Genomics
BMC Genomics, Vol 12, Iss 1, p 296 (2011)
BMC Genomics, Vol 12, Iss 1, p 296 (2011)
Background The mosquito, Anopheles gambiae, is the primary vector of human malaria, a disease responsible for millions of deaths each year. To improve strategies for controlling transmission of the causative parasite, Plasmodium falciparum, we requir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b70e54ed964d8d8298e7a3594529ffb0
https://pubmed.ncbi.nlm.nih.gov/21649883
https://pubmed.ncbi.nlm.nih.gov/21649883