Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Alex Petrucelli"'
Autor:
Meng Deng, Jason W. Tam, Lufei Wang, Kaixin Liang, Sirui Li, Lu Zhang, Haitao Guo, Xiaobo Luo, Yang Zhang, Alex Petrucelli, Beckley K. Davis, Brian J. Conti, W. June Brickey, Ching-Chang Ko, Yu L. Lei, Shaocong Sun, Jenny P. -Y. Ting
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
RNA viruses can be detected by immune cell pattern recognition receptors, such as RLRs, resulting in MAVS-TBK1-IRF3 signalling and production of antiviral type 1 interferons. Here the authors show that macrophage TRAF3-interacting protein 3 regulates
Externí odkaz:
https://doaj.org/article/17cacfe2c68542b2a667a747cf1f862c
Autor:
Zhe Ma, Sharon E Hopcraft, Fan Yang, Alex Petrucelli, Haitao Guo, Jenny P-Y Ting, Dirk P Dittmer, Blossom Damania
Publikováno v:
PLoS Pathogens, Vol 13, Iss 5, p e1006350 (2017)
Kaposi's sarcoma-associated herpesvirus (KSHV) is a herpesvirus that is linked to Kaposi's sarcoma (KS), primary effusion lymphoma (PEL) and multicentric Castleman's disease (MCD). KSHV establishes persistent latent infection in the human host. KSHV
Externí odkaz:
https://doaj.org/article/4ef0b36d20234d92939783e96142ef8a
Autor:
Jason Buehler, Sebastian Zeltzer, Justin Reitsma, Alex Petrucelli, Mahadevaiah Umashankar, Mike Rak, Patricia Zagallo, Joyce Schroeder, Scott Terhune, Felicia Goodrum
Publikováno v:
PLoS Pathogens, Vol 12, Iss 5, p e1005655 (2016)
Herpesviruses persist indefinitely in their host through complex and poorly defined interactions that mediate latent, chronic or productive states of infection. Human cytomegalovirus (CMV or HCMV), a ubiquitous β-herpesvirus, coordinates the express
Externí odkaz:
https://doaj.org/article/fd0c2f18ecf145d0800e6c97576e9a8a
Autor:
Mahadevaiah Umashankar, Alex Petrucelli, Louis Cicchini, Patrizia Caposio, Craig N Kreklywich, Michael Rak, Farah Bughio, Devorah C Goldman, Kimberly L Hamlin, Jay A Nelson, William H Fleming, Daniel N Streblow, Felicia Goodrum
Publikováno v:
PLoS Pathogens, Vol 7, Iss 12, p e1002444 (2011)
Clinical strains of HCMV encode 20 putative ORFs within a region of the genome termed ULb' that are postulated to encode functions related to persistence or immune evasion. We have previously identified ULb'-encoded pUL138 as necessary, but not suffi
Externí odkaz:
https://doaj.org/article/ad3d589c837c45a4a85163673d1fb1ed
Autor:
W. June Brickey, Shao Cong Sun, Beckley K. Davis, Kaixin Liang, Jenny P.-Y. Ting, Lufei Wang, Jason W. Tam, Sirui Li, Yang Zhang, Alex Petrucelli, Haitao Guo, Brian J. Conti, Meng Deng, Ching-Chang Ko, Lu Zhang, Yu Lei, Xiaobo Luo
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
Innate immunity to nucleic acids forms the backbone for anti-viral immunity and several inflammatory diseases. Upon sensing cytosolic viral RNA, retinoic acid-inducible gene-I-like receptors (RLRs) interact with the mitochondrial antiviral signaling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d78e8e350dbeefd601e6a0ab966173d8
https://doaj.org/article/17cacfe2c68542b2a667a747cf1f862c
https://doaj.org/article/17cacfe2c68542b2a667a747cf1f862c
Autor:
Rachid El Morabiti, Karen V. Swanson, Jenny P.-Y. Ting, Glen N. Barber, Cathryn J. Kurkjian, Elizabeth Holley-Guthrie, Avani A. Pendse, Robert D. Junkins, Chris A. Benedict, Alex Petrucelli
Publikováno v:
The Journal of Experimental Medicine
In this issue of JEM, Swanson et al. report an unanticipated role for cGAMP in priming and activation of inflammasomes in addition to its well-characterized function as an endogenous second messenger inducing type I interferons in the cytosolic DNA-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5f81f8bbe33d8c531c9ec07c21ad9f3
https://doi.org/10.1084/jem.20171749
https://doi.org/10.1084/jem.20171749
Autor:
Li-Chung Tsao, Brice E. Barefoot, Yong Liu, Haitao Guo, Melissa Samo, Blossom Damania, Jenny P.-Y. Ting, Maximilian Riess, Qi Wang, Yanping Zhang, Haitao Wen, Hui Feng, Sumit K. Chanda, Alex Petrucelli, Lishan Su, Meng Deng, Sunnie M. Yoh, Zhigang Zhang, Joseph A. Duncan, Gregory D. Sempowski, Jinyao Mo, Anamaris M. Colberg-Poley, Aiping Zhang, Renate König, Lu Zhang, Stanley M. Lemon
Publikováno v:
Cell Host & Microbe. 19:515-528
SummaryUnderstanding the negative regulators of antiviral immune responses will be critical for advancing immune-modulated antiviral strategies. NLRX1, an NLR protein that negatively regulates innate immunity, was previously identified in an unbiased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c42872b84492651b95a085869fd3b47f
https://doi.org/10.1016/j.chom.2016.03.001
https://doi.org/10.1016/j.chom.2016.03.001
Autor:
W. June Brickey, Meng Deng, Xianming Tan, Kevin D. Cook, Yoshitaka Oyama, Haitao Guo, Alex Petrucelli, Elena Rampanelli, Ichiro Misumi, Jason W. Tam, Jenny P.-Y. Ting, Justin E. Wilson, Jason K. Whitmire, Brandon M. Johnson, Toru Uchimura, Wei-Chun Chou, Liang Chen
NLRC3 limits inflammatory signaling in myeloid cells, but its role in T cells has been unclear. Uchimura et al. reveal that T cell expression of Nlrc3 restricts autoimmune and virus-specific CD4 + T cell responses by attenuating T cell signaling and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a32cf09fb020ee463aaaa09c4cb5a38
Autor:
Jenny P.-Y. Ting, A. Alicia Koblansky, Monika Schneider, Beckley K. Davis, Christian Jobin, Dale A. Ramsden, Alex Petrucelli, Yuli Wang, Agnieszka D. Truax, Brianne R. Barker, Marcus Mühlbauer, Nancy L. Allbritton, Justin E. Wilson, Yoshitaka Oyama, W. June Brickey, Arlin B. Rogers, Wei-Chun Chou, Liang Chen
Publikováno v:
Nature Medicine. 21:906-913
The inflammasome activates caspase-1 and the release of interleukin-1β (IL-1β) and IL-18, and several inflammasomes protect against intestinal inflammation and colitis-associated colon cancer (CAC) in animal models. The absent in melanoma 2 (AIM2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3e85e7153ea445cf3609e212a0440ff
https://doi.org/10.1038/nm.3908
https://doi.org/10.1038/nm.3908
Autor:
Fan Yang, Zhe Ma, Blossom Damania, Haitao Guo, Jenny P.-Y. Ting, Alex Petrucelli, Sharon E. Hopcraft, Dirk P. Dittmer
Publikováno v:
PLoS Pathogens, Vol 13, Iss 5, p e1006350 (2017)
PLoS Pathogens
PLoS Pathogens
Kaposi’s sarcoma-associated herpesvirus (KSHV) is a herpesvirus that is linked to Kaposi’s sarcoma (KS), primary effusion lymphoma (PEL) and multicentric Castleman’s disease (MCD). KSHV establishes persistent latent infection in the human host.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92c5c0195cc5f974ecdcad62ce8a7183
http://europepmc.org/articles/PMC5426799?pdf=render
http://europepmc.org/articles/PMC5426799?pdf=render